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1.

001-es BibID:BIBFORM085533
Első szerző:Amélia Santos, M.
Cím:A new bipodal carboxy-bis(hydroxypyridinonate) ligand: Synthesis and complexation with copper(II), nickel(II) and zinc(II) in aqueous solution / Amélia Santos M., Grazina Raquel, Buglyó Péter, Gama Sofia, Farkas Etelka
Dátum:2002
ISSN:0277-5387
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Polyhedron. - 21 : 25-26 (2002), p. 2609-2616. -
További szerzők:Grazina, Raquel Buglyó Péter (1965-) (vegyész) Gama, Sofia Farkas Etelka (1948-) (vegyész)
Pályázati támogatás:OTKA T034674
OTKA
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2.

001-es BibID:BIBFORM086424
Első szerző:Farkas Etelka (vegyész)
Cím:Dihydroxamate based siderophore model, piperazine-1,4-bis-(N-methyl-acetohydroxamic acid (PIPDMAHA), as a chelating agent of molybdenum(VI) / Etelka Farkas, Hajnalka Csóka, Sofia Gama, Amélia M. Santos
Dátum:2002
ISSN:0039-9140 1873-3573
Megjegyzések:Equilibrium studies based on pH?potentiometric and spectrophotometric measurements as well as some theoretical simulations are reported for the complexes of Mo(VI) with a dihydroxamate type siderophore analogue, the piperazine-1,4-bis-(N-methyl-acetohydroxamic acid) (PIPDMAHA). It has been found that the complexation process starts below pH 2 and that PIPDMAHA forms more stable O,O-hydroxamate bis-chelated complexes with Mo(VI) than any of the formerly studied dihydroxamic acids. The experimental data were fitted with two complexation models based either on dinuclear or on mononuclear species. However, ESI-MS showed that the dimmer is much more abundant than the monomer. This feature was further suggested by theoretical simulation studies, which indicated the dimeric species is more stable than the monomeric one.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Siderophore analogues
Molybdenum
Hydroxamic acid
Chelating agent
Megjelenés:Talanta. - 57 : 5 (2002), p. 935-943. -
További szerzők:Csóka Hajnalka Gama, Sofia Santos, Amélia M.
Pályázati támogatás:T23612
OTKA
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3.

001-es BibID:BIBFORM010516
Első szerző:Gama, Sofia
Cím:A bis(3-hydroxy-4-pyridinone)-EDTA derivative as a strong chelator for M3+ hard metal ions: complexation ability and selectivity / Sofia Gama, Paul Dron, Silvia Chaves, Etelka Farkas, M. Amélia Santos
Dátum:2009
ISSN:1477-9226
Megjegyzések:The study of chelating compounds is very important to solve problems related to human metal overload. 3-Hydroxy-3-pyridinones (HP), namely deferiprone, have been clinically used for chelating therapy of Fe and Al over the last decade. A multi-disciplinary search for alternative molecules led us to develop poly-(3-hydroxy-4-pyridinones) to increase metal chelation efficacy. We present herein a complexation study of a new bis-(3-hydroxy-4-pyridinone)-EDTA derivative with a set of M3+ hard metal ions (M = Fe, Al, Ga), as well as Zn2+, a biologically relevant metal ion. Thus a systematic aqueous solution equilibrium study was performed using potentiometric and spectroscopic techniques (UV-Vis, NMR methods). These set of results enables the establishment of specific models as well as the determination of thermodynamic stability constants and coordination modes of the metal complexes. The results indicate that this ligand has a higher affinity for chelating to these hard metal ions than deferiprone, and that the coordination occurs mostly through the HP moieties. Furthermore, it was also found that this ligand has a higher selectivity for chelating to M3+ hard metal ions (M = Fe, Al, Ga) than Zn2+.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Dalton Transactions. - (2009), p. 6141-6150. -
További szerzők:Dron, Paul Chaves, Silvia Farkas Etelka (1948-) (vegyész) Santos, Amélia M.
Internet cím:DOI
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4.

001-es BibID:BIBFORM010517
Első szerző:Gama, Sofia
Cím:Combined chelation of bi-functional bis-hydroxypiridinone and mono-hydroxypiridinone : Synthesis, solution and in vivo evaluation / Sofia Gamaa, Marco Gil, Lurdes Gano, Etelka Farkas, M. Amélia Santos
Dátum:2009
ISSN:0162-0134
Megjegyzések:3-Hydroxy-4-pyridinones (3,4-HP) are well known iron-chelators with applications in medicinal chemistry, mainly associated with their high affinity towards trivalent hard metal ions (e.g. M3+ M = Fe, Al, Ga) and use as decorporating agents in situations of metal accumulation. The polydenticity and the extra-functionality of 3,4-HP derivatives have been explored, aimed at improving the chelating efficacy and the selectivity of the interaction with specific biological receptors. However, the ideal conjugation of both features in one molecular unity usually leads to high molecular weight compounds which can have crossing-membrane limitations. Herein, a different approach is used combining a arylpiperazine-containing bis-hydroxypyridone (H2L1) with a biomimetic mono-hydroxypyridinone, ornithine-derivative (HL2), to assess the potential coadjuvating effect that could result from the administration of both compounds for the decorporation of hard metal ions. This work reports the results of solution and in vivo studies on their chelating efficacy either as a simple binary or a ternary system (H2L1:HL2:M3+), using potentiometric and spectrophotometric methods. The solution complexation studies with Fe(III) indicate that the solubility of the complexes is considerably increased in the ternary system, an important feature for the metal complex excretion, upon the metal sequestration. The results of the in vivo studies With Ga-67-injected mice show differences on the biodistribution profiles of the radiotracer, upon the administration of each chelating agent, that are mainly ascribed to the differences of their extra-functional groups and lipo/hydrophilic character. However, administration of both chelating agents leads to a more steady metal mobilization, which may be attributed to an improved access to different cellular compartments. (C) 2008 Elsevier Inc. All rights reserved.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Inorganic Biochemistry. - 103 : 2 (2009), p. 288-298. -
További szerzők:Gil, Marco Gano, Lurdes Farkas Etelka (1948-) (vegyész) Santos, Amélia M.
Internet cím:DOI
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5.

001-es BibID:BIBFORM084834
Első szerző:Santos, Amélia M.
Cím:A new bis(3-hydroxy-4-pyridinone)-IDA derivative as a potential therapeutic chelating agent : synthesis, metal-complexation and biological assays / M. Amélia Santos, Sofia Gama, Lurdes Gano, Guilhermina Cantinho, Etelka Farkas
Dátum:2004
ISSN:1477-9226
Megjegyzések:A new bis(3-hydroxy-4-pyridinone) derivative of iminodiacetic acid, imino-bis(acetyl(1-(3'-aminopropyl)-3-hydroxy-2-methyl-4-pyridinone)), IDAPr(3,4-HP)(2), has been prepared and studied in its interaction with a set of hard metal ions. This tetradentate ligand presents a much higher chelating efficiency for trivalent hard metal ions (Fe, Ga, Al) than the monodentate derivative Deferriprone, namely at the diluted conditions prevailing in physiological conditions and at low clinical doses. A similar behaviour was also observed for the complexation with Zn(II) but at a significantly lower extent. This compound presents a moderate hydrophilic character at physiological pH (logD=-1.72). In vivo assays showed much more rapid clearance of (67)Ga from most tissues of metal-loaded mice than the drug Deferriprone and the radioactivity excretion occurs mostly through the kidneys. Therefore, results from in vitro and in vivo studies indicated good perspectives for this compound to be a potential decorporating agent for hard metal ions in overload situations without depletion of essential metal ions such as zinc.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Dalton Transactions. - 2004 : 21 (2004), p. 3772-3781. -
További szerzők:Gama, Sofia Gano, Lurdes Cantinho, Guilhermina Farkas Etelka (1948-) (vegyész)
Pályázati támogatás:OTKA T034674
OTKA
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6.

001-es BibID:BIBFORM082443
Első szerző:Santos, Amélia M.
Cím:Bis(3-hydroxy-4-pyridinone)-EDTA derivative as a potential therapeutic Al-chelating agent : synthesis, solution studies and biological assays / M. Amélia Santos, Sofia Gama, Lurdes Gano, Etelka Farkas
Dátum:2005
ISSN:0162-0134
Megjegyzések:The 3-hydroxy-4-pyridinones are chelating agents of current interest due to their high affinity for hard metal ions and potential clinical applications as metal-decorporation agents. A new bis-(3-hydroxy-4-pyridinone) derivative of EDTA have been developed, and herein we describe the results of solution studies to determine the protonation constants and the partition coefficient. Biodistribution studies, performed with 67Ga-overload mice, showed rapid clearance of the radiotracer from the body, thus indicating that the new ligand should be a quite effective agent for the in vivo aluminium removal.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Inorganic Biochemistry. - 99 : 9 (2005), p. 1845-1852. -
További szerzők:Gama, Sofia Gano, Lurdes Farkas Etelka (1948-) (vegyész)
Pályázati támogatás:OTKA T049612
OTKA
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7.

001-es BibID:BIBFORM003033
Első szerző:Santos, Amélia M.
Cím:Complexation of molybdenum(VI) with bis(3-hydroxy-4-pyridinone)amino acid derivatives / M. Amélia Santos, Sofia Gama, João Costa Pessoa, M. Conceição Oliveira, Imre Tóth, Etelka Farkas
Dátum:2007
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal Of Inorganic Chemistry. - 12 (2007), p. 1728-1737. -
További szerzők:Gama, Sofia Pessoa, Joăo Costa Oliveira, M. Conceição Tóth Imre (1950-) (vegyész) Farkas Etelka (1948-) (vegyész)
Internet cím:elektronikus változat
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