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001-es BibID:	BIBFORM099414
035-os BibID:	(cikkazonosító)115590
Első szerző:	Sanna, Daniele (vegyész)
Cím:	Interaction of V(V) complexes formed by picolinic and pyrazinecarboxylic acid derivatives with red blood cells / Daniele Sanna, Péter Buglyó, Sándor Nagy, Franc Perdih, Jessica Palomba, Valeria Ugone, Eugenio Garribba
Dátum:	2022
ISSN:	0277-5387
Megjegyzések:	The interaction with red blood cells (RBC) of vanadium(V) complexes formed by 3,5-difluoropicolinic acid (HpicFF), 3-hydroxypicolinic acid (H2hypic) and pyrazinecarboxylic acid (Hprz) has been examined. Electron Paramagnetic Resonance (EPR) spectroscopy results suggest that V(V) is reduced in all cases to V(IV) inside the erythrocytes. The thermodynamic stability of V(V) and corresponding V(IV) complexes has been related with the species detected in the cellular environment; when the ligands form unstable complexes with both VVO2+and VIVO2+ions (picFF and prz), the species formed inside RBC are similar to those observed when starting with vanadate(V) alone, that is VIVO2+? formed upon V(V) reduction ? which distributes among the cellular bio-ligands forming different types of complexes. When in the ligand molecule other groups able to form chelated complexes are present (H2hypic), more stable species are formed inside the RBC. The amount of complex able to enter the RBC depends on the ligand structure which could influence the metal uptake. The interaction of different VIVO2+complexes formed by picolinate (picFF, pic =picolinate, picCN =5-cyanopicolinate) and pyrazinecarboxylate (prz and przNH2 =3-aminopyrazine-2-carboxylate) derivatives with hemoglobin (Hb), which is the main candidate to bind the VIVO2+ion in the cytosol, was also investigated to rationalize the results. The ligands which form at physiological pH relatively stable complexes with VIVO2+(przNH2 and pic) can give inside the erythrocytes mixed species after the replacement of an equatorial water molecule by an imidazole nitrogen of a histidine residue of the protein, while the ligands which form with VIVO2+unstable complexes (picCN, picFF, prz) yield the same species observed in the binary system VIVO2+?Hb.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk vanádium komplex
Megjelenés:	Polyhedron. - 212 (2022), p. 1-7. -
További szerzők:	Buglyó Péter (1965-) (vegyész) Nagy Sándor (1993-) (vegyész) Perdih, Franc Palomba, Jessica Ugone, Valeria Garribba, Eugenio
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM099412
035-os BibID:	(WoS)000457067600018 (Scopus)85060548886
Első szerző:	Sanna, Daniele (vegyész)
Cím:	Role of Ligands in the Uptake and Reduction of V(V) Complexes in Red Blood Cells / Daniele Sanna, Jessica Palomba, Giuseppe Lubinu, Péter Buglyó, Sándor Nagy, Franc Perdih, Eugenio Garribba
Dátum:	2018
ISSN:	0022-2623 1520-4804
Megjegyzések:	The interaction with erythrocytes of four [(VO2L2)-O-V](-) complexes, with L = picolinate (pic), 5-cyanopicolinate (picCN), 3-aminopyrazine-2-carboxylate (przNH(2)), and 1,2-dimethyl-3-hydroxy-4(1H)-pyridinonate (dhp), was studied. The thermodynamic stability at physiological pH is: [(VO2)-O-V(dhp)(2)](-) > [(VO2)-O-V(przNH(2))(2)](-) > [VVO2(pic)(2)](-) > [VVO2(picCN)(2)](-). With picCN and pic, V exists at physiological pH as (H2VO4-)-O-V, with przNH(2) as a mixture of (H2VO4-)-O-V and [VVO2(przNH(2))(2)](-) and with dhp as [VVO2(dhp)(2)](-). In the systems with pic and picCN, (H2VO4-)-O-V and the ligands cross the erythrocyte membrane independently, with dhp the uptake occurs by diffusion, whereas with przNH(2) both the mechanisms are active. Inside erythrocytes stable (VOL2)-O-IV complexes are formed, indicating that there is no relationship with the stability and redox state of the administered compounds and that, if the metal ion changes its oxidation state in the cytosol as V does, unstable complexes in the extracellular medium could become stable inside the cells and contribute to the pharmacological action.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk vanádium
Megjelenés:	Journal Of Medicinal Chemistry. - 62 : 2 (2018), p. 654-664. -
További szerzők:	Palomba, Jessica Lubinu, Giuseppe Buglyó Péter (1965-) (vegyész) Nagy Sándor (1993-) (vegyész) Perdih, Franc Garribba, Eugenio
Pályázati támogatás:	GINOP-2.3.2-15-2016-00008 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: