Találati lista | Tudóstér

001-es BibID:	BIBFORM016459
Első szerző:	Csapó Edit (vegyész)
Cím:	Syntheses and characterization of Cu2+, Ni2+ and Zn2+ binding capability of histidinehydroxamic acid derivatives / Edit Csapó, Péter Buglyó, Nóra Veronika Nagy, M. Amélia Santos, Alma Coronad, Etelka Farkas
Dátum:	2010
ISSN:	0277-5387
Megjegyzések:	Two histidinehydroxamic acid derivatives (N-methyl-histidinehydroxamic acid, N-Me-Hisha and Z-histidinehydroxamic acid, Z-Hisha) have been synthesized and their complexation with Cu2+-, Ni2+- and Zn2+-ions has been studied by using pH-potentiometric, UV-Vis, CD, H-1 NMR, EPR and ESI-MS methods. Both of the two new derivatives contain one donor atom less compared to the histidinehydroxamic acid (Hisha). In the case of N-Me-Hisha the hydroxamate-N as donor is eliminated, while the coordination of the amino-N of Z-Hisha is not possible at all. With the ambidentate N-Me-Hisha, the histamine-type coordination mode is favoured if the metal ion is Ni2+ and the bis-[NH2,N-imid] complex is the most stable in this system. The mixed type, [NH2,N-imid] + [O,O], coordination mode dominates in the Cu2+- N-Me-Hisha complexes, while different low stability mono-chelated linkage isomers are formed with Zn2+. With Z-Hisha (having poor water solubility) hydroxamate-type coordination mode predominates in low stability complexes in the Ni2+ and Zn2+ containing systems. Interestingly, the interaction with Cu2+ is very strong and results in the formation of a high stability 12-MC-4 type metallacrown with involvement of 5-membered and 7-membered chelates. (C) 2010 Elsevier Ltd. All rights reserved.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Histidinehydroxamic acid derivatives Cu2+-, Ni2+-, Zn2+-complexes Solution equilibrium Potential metalloenzyme inhibitors matrix-metalloproteinase inhibitors mixed-ligand complexes aqueous-solution hydroxamic acids aminohydroxamic acids copper(ii) complexes methioninehydroxamic acids dissociation-constants metal complexation coordination
Megjelenés:	Polyhedron. - 29 : 16 (2010), p. 3137-3145. -
További szerzők:	Buglyó Péter (1965-) (vegyész) Nagy Nóra Veronika Santos, Amélia M. Corona, Alma Farkas Etelka (1948-) (vegyész)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM084835
Első szerző:	Farkas Etelka (vegyész)
Cím:	Interaction of desferrioxamine B (DFB) model dihydroxamic acids with some essential and toxic metal(II) ions: effects of the structure and length of connecting chains on the metal ion selectivity / Etelka Farkas, Dávid Bátka, Zoltán Pataki, Péter Buglyó, M. Amelia Santos
Dátum:	2004
ISSN:	1477-9226
Megjegyzések:	Complexation of desferrioxamine B (DFB) model dihydroxamic acids (HO(CH3)NCO(CH2)xCONH(CH2)yCON(CH3)OH where x = 2, 3, y = 5, 4, 3, 2, and the compounds are abbreviated as 2,5-DIHA, 2,4-DIHA, 2,3-DIHA, 2,2-DIHA, 3,4-DIHA and 3,3-DIHA, respectively) with Cu(II), Ni(II), Zn(II), Pb(II) and Cd(II) was studied by pH-potentiometric and spectroscopic (UV-VIS, NMR and ESI-MS) techniques. The effects of the position of the peptide group, the chain length and the geometry on the stability and stoichiometry of the complexes formed were evaluated. It was concluded that metal ions preferring regular octahedral geometry in their complexes form the most stable bis-chelated mononuclear complexes, [ML], with 2,5-DIHA having the same connecting chain structure and length as those of DFB. This benefit of 2,5-DIHA, however, almost disappears in the case of Cu(II). With this metal, which prefers the equatorial coordination of two hydroxamates, the parallel formation of both [CuL] and [Cu2L2] was found. ESI-MS results indicate that the latter complex is exclusively formed with 2,2-DIHA involving the shortest linker. All these dihydroxamic acids are excellent chelating agents for Pb(II). The special geometry determined by the lone pair electrons should be responsible for the somewhat unique preference order of the ligands towards the Pb(II) ion, for the favoured formation of the monomeric bis-chelated complexes and also for the unexpectedly high stability of the species [Pb(2,2-DIHA)].
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Dalton Transactions. - 2004 : 8 (2004), p. 1248-1253. -
További szerzők:	Bátka Dávid (1980-) (vegyész) Pataki Zoltán Buglyó Péter (1965-) (vegyész) Santos, Amélia M.
Pályázati támogatás:	OTKA T034674 OTKA OTKA TS040685 OTKA TET PORT-5/01 egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: