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1.

001-es BibID:BIBFORM081489
Első szerző:He, Xuedan
Cím:RGD peptide-modified multifunctional dendrimer platform for drug encapsulation and targeted inhibition of cancer cells / Xuedan He, Carla S. Alves, Nilsa Oliveira, João Rodrigues, Jingyi Zhu, István Bányai, Helena Tomás, Xiangyang Shi
Dátum:2015
ISSN:0927-7765
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Dendrimers
RGD peptide
Doxorubicin
Host-guest interaction
Targeted cancer therapy
Megjelenés:Colloids And Surfaces B-Biointerfaces. - 125 (2015), p. 82-89. -
További szerzők:Alves, Carla S. Oliveira, Nilsa Rodrigues, João Zhu, Jingyi Bányai István (1953-) (vegyész) Tomás, Helena Shi, Xiangyang
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0043
TÁMOP
TET_12_CN-1-2012-0032
Egyéb
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2.

001-es BibID:BIBFORM057170
Első szerző:Kéri Mónika (környezetkutató vegyész)
Cím:NMR Characterization of PAMAM_G5.NH2 Entrapped Atomic and Molecular Assemblies / Mónika Kéri, Chen Peng, Xiangyang Shi, István Bányai
Dátum:2015
ISSN:1520-6106
Megjegyzések:High resolution NMR spectroscopy, NMR diffusiometry and NMR cryoporometry have been used to investigate aqueous solution (D2O) of PAMAM_G5.NH2-(Au)25-100 and PAMAM_G5.NH2-(H2O)1000 - (H2O)4000 systems. In case of dendrimer entrapped gold nanoparticles the detailed analysis of high resolution NMR spectra has shown that no precursor complex formation happens under the circumstances applied for reduction. Further PGSE results verify that gold nanoparticles of 1.9-2.6 nm size are entrapped in the outermost part of the dendrimers and probably more than one dendrimer molecule take part in the stabilization process. This system looks like a transition state between dendrimer encapsulated nanoparticles (DENs) and dendrimer stabilized nanoparticles (DSNs) and we deal in details what it means. NMR cryoporometry experiments were performed to detect the encapsulation of water molecules. The results show that in the swelling PAMAM_G5.NH2 dendrimers, by adding water step by step, there are specific cavities for water with diameter of 3.6 and 5.2 nm. These cavities have penetrable wall for water molecules and probably exist very close to the terminal groups. The permeability of the cavities is increasing with the increase of the water content. In dilute solution the formation of nanoparticles is determined by the ratio of the rate of nucleation and aggregation and this latter is affected by the PAMAM_G5.NH2.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
poli(amido-amine) dendrimerek
arany nanorészecskék
NMR diffúziometria
NMR krioporometria
stabilizálás
kapszulázás
Megjelenés:The Journal of Physical Chemistry B. - 119 : 7 (2015), p. 3312-3319. -
További szerzők:Peng, Chen Shi, Xiangyang Bányai István (1953-) (vegyész)
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3.

001-es BibID:BIBFORM103440
035-os BibID:(Wos)000454922000007 (Scopus)85059537840
Első szerző:Li, Dan
Cím:Design of dual drug-loaded dendrimer/carbon dot nanohybrids for fluorescence imaging and enhanced chemotherapy of cancer cells / Dan Li, Yu Fan, Mingwu Shen, István Bányai, Xiangyang Shi
Dátum:2019
ISSN:2050-750X 2050-7518
Megjegyzések:Design of powerful nanosystems to overcome multidrug resistance (MDR) for effective chemotherapy of cancer currently remains a great challenge. Herein, we report the development of a poly(amidoamine) (PAMAM) dendrimer/carbon dot nanohybrid for dual drug loading to overcome MDR and simultaneously monitor cancer cells via fluorescence imaging. First, blue-emitting carbon dots (CDs) were synthesized using sodium citrate as a carbon source via the hydrothermal method and used as a carrier to load the anticancer drug doxorubicin (DOX) through non-covalent interactions, thus forming CDs/DOX complexes. In parallel, PAMAM dendrimers of generation 5 (G5) were covalently modified by the targeting ligand cyclic arginine-glycine-aspartic (RGD) peptide and the drug efflux inhibitor d--tocopheryl polyethylene glycol 1000 succinate (TPGS). Then, through electrostatic interaction, functional dendrimers (G5-RGD-TPGS) were complexed with CDs/DOX complexes to form a dual drug-loaded nanohybrid system. The dual drug-loaded dendrimer/CD nanohybrids were well characterized. We showed that the nanohybrids possessed good colloidal stability and enabled significant inhibition of cancer cells due to the presence of TPGS, which can inhibit P-glycoprotein (P-gp) by decreasing ATP levels and increasing ROS levels; simultaneously, fluorescence imaging of cancer cells could be achieved in vitro due to the luminescence of CDs. In addition, the attached RGD ligands rendered the nanohybrid with targeting specificity to cancer cells expressing (v3) integrin receptors. The developed dual drug-loaded dendrimer/CD nanohybrid may be used as a promising theranostic platform to overcome MDR for enhanced chemotherapy as well as for fluorescence imaging of cancer cells.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Materials Chemistry B. - 7 : 2 (2019), p. 277-285. -
További szerzők:Fan, Yu Shen, Mingwu Shi, Xiangyang Bányai István (1953-) (vegyész)
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
GINOP
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4.

001-es BibID:BIBFORM103470
035-os BibID:(cikkazonosító)7 (WOS)000513234900001 (Scopus)85078853991
Első szerző:Liu, Jinyuan
Cím:Characterization of zwitterion-modified poly(amidoamine) dendrimers in aqueous solution via a thorough NMR investigation / Jinyuan Liu, Zhijuan Xiong, Mingwu Shen, Istvan Banyai, Xiangyang Shi
Dátum:2020
ISSN:1292-8941
Megjegyzések:Zwitterions are a class of unique molecules that can be modified onto nanomaterials to render them with antifouling properties. Here we report a thorough NMR investigation of dendrimers modified with zwitterions in terms of their structure, hydrodynamic size, and diffusion time in aqueous solution. In this present work, poly(amidoamine) (PAMAM) dendrimers of generation 5 (G5) were partially decorated with carboxybetaine acrylamide (CBAA), 2-methacryloyloxyethyl phosphorylcholine (MPC), and 1,3-propane sultone (1,3-PS), respectively with different modification degrees. The formed zwitterion-modified G5 dendrimers were characterized using NMR techniques. We show that the zwitterion modification leads to increased G5 dendrimer size in aqueous solution, suggesting that the modified zwitterions can form a hydration layer on the surface of G5 dendrimers. In addition, the hydrodynamic sizes of G5 dendrimers modified with different zwitterions but with the same degree of surface modification are discrepant depending on the type of zwitterions. The present study provides a new physical insight into the structure of zwitterion-modified G5 dendrimers by NMR techniques, which is beneficial for further design of different biomedical applications.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Topical issue
Branching Dynamics at the Mesoscopic Scale
Megjelenés:European Physical Journal E. - 43 : 2 (2020), p. 1-7. -
További szerzők:Xiong, Zhijuan Shen, Mingwu Bányai István (1953-) (vegyész) Shi, Xiangyang
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5.

001-es BibID:BIBFORM114853
035-os BibID:(WoS)001048171000001 (Scopus)85169002443
Első szerző:Novák Levente (biológus)
Cím:Synthesis and Characterization of Carboxymethylated Polyethylenimines / Levente Novák, Tamás S. Miklósi, Dávid Nyul, Xiangyang Shi, István Bányai
Dátum:2023
ISSN:2637-6105
Megjegyzések:As potential paramagnetic metal ion complexing macromolecular ligands, carboxymethylated polyethylenimines (CM-PEIs) were successfully prepared from polyethylenimine (PEI) with 2-chloroacetic acid (CA) in an alkaline medium. SEC, pH-potentiometry, DLS, and multinuclear and multidimensional NMR techniques were used to determine the degree of functionalization, size, and possible structure of the modified polymers. By varying the amount of CA, functionalization degrees of 7?67% relative to the theoretical maximum were achieved. Diffusometry shows that the PEI and CM-PEIs are highly hydrated. The CM-PEIs are larger molecules than the parent PEI, although their hydrodynamic size decreases with higher degrees of functionalization. CM-PEIs are isostable except for the most highly substituted derivative. CM-PEIs form complexes with Cu(II) and efficiently decrease the rate of the copper-mediated oxidation of ascorbic acid. The good affinity toward cations of CM-PEI functionalized at 67% is further demonstrated by its capacity to bind even sodium ions. These properties show that CM-PEIs are promising metal-chelating polymers for diagnostic or theranostic purposes.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
karboximetilezett polietilénimin
progresszív funkcionalizáció
polimer jellemzés
többdimenziós és multinukleáris NMR
protonaffinitás spektrum
réz(II)-komplex
nátrium kötés
makromolekuláris ligandum
Megjelenés:ACS Applied Polymer Materials. - 5 : 9 (2023), p. 7208-7219. -
További szerzők:Miklósi Tamás Sándor (PhD hallgató) Nyul Dávid (1993-) (vegyészmérnök) Shi, Xiangyang Bányai István (1953-) (vegyész)
Pályázati támogatás:NKFIH KA_131989
OTKA
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6.

001-es BibID:BIBFORM095727
Első szerző:Shi, Xiangyang
Cím:Electrophoretic mobility and molecular distribution studies of poly(amidoamine) dendrimers of defined charges / Xiangyang Shi, István Bányai, Keyla Rodriguez, Mohammad T. Islam, Wojciech Lesniak, Peter Balogh, Lajos P. Balogh, James R. Baker
Dátum:2006
ISSN:0173-0835 1522-2683
Megjegyzések:Generation 5 ethylenediamine (EDA)-cored poly(amidoamine) (PAMAM) dendrimers(E5, E d enotes the EDA core and 5 the generation number) with different degrees of acetylation and carboxylation were synthesized and used as a model system to investigate the effect of charge and the influence of dendrimer surface modifications on electrophoretic mobility (EM) and molecular distribution. The surface-modified dendrimers were characterized by size-exclusion chromatography, 1H NMR, MALDITOF-MS, PAGE, and CE. The focus of our study was to determine how EM changes as a function of particle charge and molecular mass, and how the molecular distribution changes due to surface modifications. We demonstrate that partially modified dendrimers have much broader migration peaks than those of fully surface functionalized or unmodified E5 dendrimers due to variations in the substitution of individual dendrimer surfaces. EM decreased nonlinearly with increases in surface acetylation for both PAMAM acetamides and PAMAM succinamic acids, indicating a complex migration activity in CE separations that is not solely due to charge/mass ratio changes. These studies provide new insights into dendrimer properties under an electric field, as well as into the characterization of dendrimer-based materials being developed for medical applications.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Capillary electrophoresis
Electrophoretic mobility
Molecular distribution
Poly(amidoamine) dendrimers
Megjelenés:Electrophoresis. - 27 : 9 (2006), p. 1758-1767. -
További szerzők:Bányai István (1953-) (vegyész) Rodriguez, Keyla Islam, Mohammad T. Lesniak, Wojciech G. Balogh Péter Balogh Lajos P. Baker, James R.
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7.

001-es BibID:BIBFORM085630
Első szerző:Shi, Xiangyang
Cím:Generational, skeletal and substitutional diversities in generation one poly(amidoamine) dendrimers / Xiangyang Shi, István Bányai, Mohammad T. Islam, Wojciech Lesniak, Denzel Z. Davis, James R. Baker, Lajos P. Balogh
Dátum:2005
ISSN:0032-3861
Megjegyzések:Structural deviations of ethylenediamine core polyamidoamine (PAMAM) dendrimers and derivatives can be defined as skeletal and/or substitutional diversities. Detailed analysis of dendrimer starting materials and derivatives is necessary to understand the intrinsic characteristics of commercial dendrimer materials and their variations related to subsequent surface modifications. In this paper, structural deviations of ethylenediamine core generation 1 PAMAM dendrimers (PAMAM_E1 or E1) are studied and determined in a frame of a systematic investigation using combined characterization techniques. A primary amine-terminated PAMAM dendrimer of generation 1 (E1.NH2) was used as a starting material to synthesize glycidol (E1.N(Gly)OH) and acetamide-terminated (E1.NHAc) dendrimers. The purity and homogeneity of these dendrimers were extensively characterized by polyacrylamide gel electrophoresis (PAGE), capillary electrophoresis (CE), gel permeation chromatography (GPC), acid?base titration, nuclear magnetic resonance (NMR), matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) and electrospray ionization (ESI) mass spectrometry. PAGE and CE studies showed that electrophoretic mobilities at pH 2.5 are in the order of E1.NH2>E1.N(Gly)OH>E1.NHAc. Mass spectrometry and NMR investigations (1H, 13C DEPT-135, and 13C NMR, COSY, HETCOR, NOESY) suggested that (a) the studied E1 dendrimers were generationally pure, (b) E1.NHAc and E1.N(Gly)OH dendrimers, and essentially had the same defects and skeletal diversity as E1.NH2 did. The broad distribution of the main peak in the CE electropherogram of E1.N(Gly)OH revealed the incomplete hydroxylation of E1.NH2 resulting in additional substitutional diversity between the dendrimer molecules. Potentiometric titration studies proved that overall numbers of terminal and tertiary amine groups also deviated from the theoretical values. NMR spectroscopy was applied for both qualitative and quantitative analysis of the structural defects of dendrimers and derivatives. E1.NH2 and E1.NHAc exhibited only minor deviations from ideal structures and, respectively, displayed a narrow distribution; while E1.N(Gly)OH had a much broader distribution centered around 14?3 glycidol substituents. The study of structural variations in generation 1 PAMAMs provides new insights for the characterization of higher generation PAMAM dendrimers and derivatives both in terms of the skeletal deviations as well as other resulting diversities related to dendrimer surface functionalization.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
dendrimer
distribution
Characterization
Megjelenés:Polymer. - 46 : 9 (2005), p. 3022-3034. -
További szerzők:Bányai István (1953-) (vegyész) Islam, Mohammad T. Lesniak, Wojciech G. Davis, Denzel Z. Baker, James R. Balogh Lajos P.
Pályázati támogatás:T-035127
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8.

001-es BibID:BIBFORM085273
Első szerző:Shi, Xiangyang
Cím:Capillary electrophoresis of polycationic poly(amidoamine) dendrimers / Xiangyang Shi, István Bányai, Wojciech G. Lesniak, Mohammad T. Islam, István Országh, Peter Balogh, James R. Baker, Jr. Lajos P. Balogh
Dátum:2005
ISSN:0173-0835 1522-2683
Megjegyzések:Generation 2 to generation 5 poly(amidoamine) (PAMAM) dendrimers having different terminal functionalities were analyzed by capillary electrophoresis (CE). Polyacrylamide gel electrophoresis was also used to assess the composition of the individual generations for comparison with the CE results. Separation of PAMAMs can be accomplished by either using uncoated silica or silanized silica capillaries, although reproducibility is poor using the uncoated silica capillary. To improve run-to-runreproducibility,silanizedcapillarywas usedandvariousinternalstandardswere alsotested. Relative and normalized migration times of primary amine terminated PAMAM dendrimers were then determined using 2,3-diaminopyridine (2,3-DAP) as an internal standard. Using silanized capillaries and internal standards, the relative and normalized migration times are fully reproducible and comparable between runs. Apparent dimensionless electrophoretic mobilities were determined and the results were compared to theoretical calculations. It is concluded that for PAMAMs a complex separation mechanism has to be considered in CE, where the movement of the ions is due to the electric field, but the separation is rather the consequence of the adsorption/desorptionequilibriaonthecapillarywall("electrokineticcapillarychromatography").The described method may be used for quality control and may serve as an effective technique to analyze polycationic PAMAM dendrimers and their derivatives with different surface modifications.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Capillary electrophoresis
Internal standards
Poly(amidoamine) dendrimers
Megjelenés:Electrophoresis. - 26 : 15 (2005), p. 2949-2959. -
További szerzők:Bányai István (1953-) (vegyész) Lesniak, Wojciech G. Islam, Mohammad T. Országh István Balogh Péter Baker, James R. Balogh Lajos P.
Pályázati támogatás:T-035127
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9.

001-es BibID:BIBFORM056646
Első szerző:Zhang, Mengen
Cím:Impact of Dendrimer Surface Functional Groups on the Release of Doxorubicin from Dendrimer Carriers / Mengen Zhang, Rui Guo, Monika Kéri, Istvan Bányai, Yun Zheng, Mian Cao, Xueyan Cao, Xiangyang Shi
Dátum:2014
ISSN:1520-6106
Megjegyzések:Generation 5 (G5) poly(amidoamine) dendrimers with acetyl (G5.NHAc), glycidol hydroxyl (G5.NGlyOH), and succinamic acid (G5.SAH) terminal groups were used to physically encapsulate an anticancer drug doxorubicin (DOX). Both UV?vis spectroscopy and multiple NMR techniques including one-dimensional NMR and two-dimensional NMR were applied to investigate the interactions between different dendrimers and DOX. The influence of the surface functional groups of G5 dendrimers on the DOX encapsulation, release kinetics, and cancer cell inhibition effect was investigated. We show that all three types of dendrimers are able to effectively encapsulate DOX and display therapeutic inhibition effect to cancer cells, which is solely associated with the loaded DOX. The relatively stronger interactions of G5.NHAc or G5.NGlyOH dendrimers with DOX than that of G5.SAH dendrimers with DOX demonstrated by NMR techniques correlate well with the slow release rate of DOX from G5.NHAc/DOX or G5.NGlyOH/DOX complexes. In contrast, the demonstrated weak interaction between G5.SAH and DOX causes a fast release of DOX, suggesting that the G5.SAH/DOX complex may not be a proper option for further in vivo research. Our findings suggest that the dendrimer surface functional groups are crucial for further design of multifunctional dendrimer-based drug delivery systems for various biomedical applications.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
PAMAM dendrimer
doxorubicin
Megjelenés:Journal Of Physical Chemistry B. - 118 : 6 (2014), p. 1696-1706. -
További szerzők:Guo, Rui Kéri Mónika (1984-) (környezetkutató vegyész) Bányai István (1953-) (vegyész) Zheng, Yun Cao, Mian Cao, Xueyan Shi, Xiangyang
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10.

001-es BibID:BIBFORM078698
035-os BibID:(WoS)000426143900011 (Scopus)85042377333
Első szerző:Zhou, Benqing
Cím:99mTc-Labeled RGD-Polyethylenimine Conjugates with Entrapped Gold Nanoparticles in the Cavities for Dual-Mode SPECT/CT Imaging of Hepatic Carcinoma / Benqing Zhou, Ruizhi Wang, Feng Chen, Lingzhou Zhao, Peng Wang, Xin Li, Bányai István, Qiang Ouyang, Xiangyang Shi, Mingwu Shen
Dátum:2018
ISSN:1944-8244
Megjegyzések:We report the construction and characterization of 99mTc-labeled arginine-glycine-aspartic acid (RGD)-polyethylenimine (PEI) conjugates with entrapped gold nanoparticles in the cavities (RGD-99mTc-Au PENPs) for dual mode SPECT/CT imaging of an orthotopic hepatic carcinoma model. In this study, PEI was successively decorated with diethylenetriaminepentaacetic acid, polyethylene glycol (PEG), and PEGylated RGD segments, and was utilized as an effective nanoplatform to entrap Au NPs and to be labelled with 99mTc. We show that the designed RGD-99mTc-Au PENPs display desirable colloidal stability and radiostability, and cytocompatibility in the investigated concentration range, and can be specifically uptaken by ?v?3 integrin-overexpressing liver cancer cells in vitro. In vivo CT and SPECT imaging results indicate that the particles are able to be accumulated within an orthotopic hepatic carcinoma and display both CT and SPECT contrast enhancement in the tumor tissue. With the proven biocompatibility in vivo via histological examinations, the designed RGD-99mTc-Au PENPs may be potentially employed as an effective nanoprobe for highly efficient dual mode SPECT/CT imaging of various ?v?3 integrin-overexpressing tumors.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
gold nanoparticles
99mTc
polyethylenimine
SPECT/CT imaging
hepatic carcinoma
Megjelenés:ACS Applied Materials and Interfaces. - 10 : 7 (2018), p. 6146-6154. -
További szerzők:Wang, Ruizhi Chen, Feng Zhao, Lingzhou Wang, Peng Li, Xin Bányai István (1953-) (vegyész) Ouyang, Qiang Shi, Xiangyang Shen, Mingwu
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
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