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001-es BibID:BIBFORM103440
035-os BibID:(Wos)000454922000007 (Scopus)85059537840
Első szerző:Li, Dan
Cím:Design of dual drug-loaded dendrimer/carbon dot nanohybrids for fluorescence imaging and enhanced chemotherapy of cancer cells / Dan Li, Yu Fan, Mingwu Shen, István Bányai, Xiangyang Shi
Dátum:2019
ISSN:2050-750X 2050-7518
Megjegyzések:Design of powerful nanosystems to overcome multidrug resistance (MDR) for effective chemotherapy of cancer currently remains a great challenge. Herein, we report the development of a poly(amidoamine) (PAMAM) dendrimer/carbon dot nanohybrid for dual drug loading to overcome MDR and simultaneously monitor cancer cells via fluorescence imaging. First, blue-emitting carbon dots (CDs) were synthesized using sodium citrate as a carbon source via the hydrothermal method and used as a carrier to load the anticancer drug doxorubicin (DOX) through non-covalent interactions, thus forming CDs/DOX complexes. In parallel, PAMAM dendrimers of generation 5 (G5) were covalently modified by the targeting ligand cyclic arginine-glycine-aspartic (RGD) peptide and the drug efflux inhibitor d--tocopheryl polyethylene glycol 1000 succinate (TPGS). Then, through electrostatic interaction, functional dendrimers (G5-RGD-TPGS) were complexed with CDs/DOX complexes to form a dual drug-loaded nanohybrid system. The dual drug-loaded dendrimer/CD nanohybrids were well characterized. We showed that the nanohybrids possessed good colloidal stability and enabled significant inhibition of cancer cells due to the presence of TPGS, which can inhibit P-glycoprotein (P-gp) by decreasing ATP levels and increasing ROS levels; simultaneously, fluorescence imaging of cancer cells could be achieved in vitro due to the luminescence of CDs. In addition, the attached RGD ligands rendered the nanohybrid with targeting specificity to cancer cells expressing (v3) integrin receptors. The developed dual drug-loaded dendrimer/CD nanohybrid may be used as a promising theranostic platform to overcome MDR for enhanced chemotherapy as well as for fluorescence imaging of cancer cells.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Materials Chemistry B. - 7 : 2 (2019), p. 277-285. -
További szerzők:Fan, Yu Shen, Mingwu Shi, Xiangyang Bányai István (1953-) (vegyész)
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
GINOP
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2.

001-es BibID:BIBFORM103470
035-os BibID:(cikkazonosító)7 (WOS)000513234900001 (Scopus)85078853991
Első szerző:Liu, Jinyuan
Cím:Characterization of zwitterion-modified poly(amidoamine) dendrimers in aqueous solution via a thorough NMR investigation / Jinyuan Liu, Zhijuan Xiong, Mingwu Shen, Istvan Banyai, Xiangyang Shi
Dátum:2020
ISSN:1292-8941
Megjegyzések:Zwitterions are a class of unique molecules that can be modified onto nanomaterials to render them with antifouling properties. Here we report a thorough NMR investigation of dendrimers modified with zwitterions in terms of their structure, hydrodynamic size, and diffusion time in aqueous solution. In this present work, poly(amidoamine) (PAMAM) dendrimers of generation 5 (G5) were partially decorated with carboxybetaine acrylamide (CBAA), 2-methacryloyloxyethyl phosphorylcholine (MPC), and 1,3-propane sultone (1,3-PS), respectively with different modification degrees. The formed zwitterion-modified G5 dendrimers were characterized using NMR techniques. We show that the zwitterion modification leads to increased G5 dendrimer size in aqueous solution, suggesting that the modified zwitterions can form a hydration layer on the surface of G5 dendrimers. In addition, the hydrodynamic sizes of G5 dendrimers modified with different zwitterions but with the same degree of surface modification are discrepant depending on the type of zwitterions. The present study provides a new physical insight into the structure of zwitterion-modified G5 dendrimers by NMR techniques, which is beneficial for further design of different biomedical applications.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Topical issue
Branching Dynamics at the Mesoscopic Scale
Megjelenés:European Physical Journal E. - 43 : 2 (2020), p. 1-7. -
További szerzők:Xiong, Zhijuan Shen, Mingwu Bányai István (1953-) (vegyész) Shi, Xiangyang
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3.

001-es BibID:BIBFORM078698
035-os BibID:(WoS)000426143900011 (Scopus)85042377333
Első szerző:Zhou, Benqing
Cím:99mTc-Labeled RGD-Polyethylenimine Conjugates with Entrapped Gold Nanoparticles in the Cavities for Dual-Mode SPECT/CT Imaging of Hepatic Carcinoma / Benqing Zhou, Ruizhi Wang, Feng Chen, Lingzhou Zhao, Peng Wang, Xin Li, Bányai István, Qiang Ouyang, Xiangyang Shi, Mingwu Shen
Dátum:2018
ISSN:1944-8244
Megjegyzések:We report the construction and characterization of 99mTc-labeled arginine-glycine-aspartic acid (RGD)-polyethylenimine (PEI) conjugates with entrapped gold nanoparticles in the cavities (RGD-99mTc-Au PENPs) for dual mode SPECT/CT imaging of an orthotopic hepatic carcinoma model. In this study, PEI was successively decorated with diethylenetriaminepentaacetic acid, polyethylene glycol (PEG), and PEGylated RGD segments, and was utilized as an effective nanoplatform to entrap Au NPs and to be labelled with 99mTc. We show that the designed RGD-99mTc-Au PENPs display desirable colloidal stability and radiostability, and cytocompatibility in the investigated concentration range, and can be specifically uptaken by ?v?3 integrin-overexpressing liver cancer cells in vitro. In vivo CT and SPECT imaging results indicate that the particles are able to be accumulated within an orthotopic hepatic carcinoma and display both CT and SPECT contrast enhancement in the tumor tissue. With the proven biocompatibility in vivo via histological examinations, the designed RGD-99mTc-Au PENPs may be potentially employed as an effective nanoprobe for highly efficient dual mode SPECT/CT imaging of various ?v?3 integrin-overexpressing tumors.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
gold nanoparticles
99mTc
polyethylenimine
SPECT/CT imaging
hepatic carcinoma
Megjelenés:ACS Applied Materials and Interfaces. - 10 : 7 (2018), p. 6146-6154. -
További szerzők:Wang, Ruizhi Chen, Feng Zhao, Lingzhou Wang, Peng Li, Xin Bányai István (1953-) (vegyész) Ouyang, Qiang Shi, Xiangyang Shen, Mingwu
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
GINOP
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