CCL

Összesen 3 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM068398
Első szerző:Orosz László (szülész-nőgyógyász)
Cím:Maternal characteristics, ultrasound- and serum-markers at 11-13+6 weeks in pregnancies without pre-eclampsia resulting small for gestational age neonates / Orosz, L., Orosz, G., Arany, I., Fabian, A., Pap, K., Medve, L., Tóth, Z., Poka, R., Torok, O.
Dátum:2014
ISSN:0960-7692
Megjegyzések:ObjectivesSmall for gestational age (SGA) newborns are generally defined as those with a birthweight below the 10th percentile for the specific gestational age. Our aim was to investigate whether the first trimester maternal biophysical, ultrasound and serum markers show any difference between SGA and appropriate for gestational age (AGA) fetuses in pregnancies not complicated with pre-eclampsia.MethodsThis is a retrospective analysis of the data from a prospective study (TÁMOP 4.2.4. A/2-11-1-2012-0001 ♭NationalExcellence Program') for adverse pregnancy outcomes by first-trimester screening. MoM levels of serum analytes (pregnancy-associated plasma protein A (PAPP-A), human chorionic gonadotrophin (B-hCG), mean arterial pressure (MAP), body mass index (BMI), parity, smoking status, maternal history and uterine artery Doppler pulsatility index (UAPI), obtained between 11 and 13?+?6 weeks gestation, were compared between the groups of pregnancies that ended up in the delivery of alive SGA or AGA newborns. Neonates born between 24-41 weeks were included, but pregnancies with pre-eclampsia or large for gestational age (LGA) fetuses were excluded.Results1112 women were recruited in the study population, out of which 720 were selected for the analysis. Overall 40 SGA fetuses were compared with 680 controls. There were significant differences between the maternal socioeconomic status, BMI, smoking status, while there were no significant differences between the maternal age and parity. Among the first trimester markers the PAPP-A level was significantly lower and the UAPI was significantly higher in the SGA group, while there was no significant difference in the B-hCG and MAP levels between the two groups.ConclusionsThere are significant differences in the first trimester markers when comparing the two groups of pregnancies resulting SGA and AGA neonates. Further prospective studies are required to develop a cost effective screening method for SGA neonates at the 11-13?+?6 weeks.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
SGA
Megjelenés:Ultrasound In Obstetrics & Gynecology 44 : S1 (2014), p. 264. -
További szerzők:Orosz Gergő Balázs (1985-) (szülész-nőgyógyász) Arany István Fábián Anna Pap Károly Medve László Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Török Olga (1956-) (szülész-nőgyógyász, humángenetikus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM068399
Első szerző:Orosz László (szülész-nőgyógyász)
Cím:The contribution of PLGF to the performance of screening for severe pre-eclampsia in the first trimester of pregnancy in routine clinical practice / Orosz, L., Orosz, G., Arany, I., Fabian, A., Pap, K., Medve, L., Tóth, Z., Poka, R., Torok, O.
Dátum:2014
ISSN:0960-7692
Megjegyzések:ObjectivesThe association between pre-eclampsia (PE),first trimester high uterine artery pulsatility index (UtA-PI),low maternal serum pregnancy-associated plasma protein A (PAPP-A), placental growth factor (PLGF) levels and certain maternal characteristics is well known. Earlier studies have shown that these first trimester markers can predict PE with a detection rate of 60-90%. The aim of this study (TÁMOP4.2.4.A/2-11-1-2012-0001) was to determine the contribution of PLGF to the performance of screening for severe PE in singleton pregnancies in our routine clinical practice.MethodsThis is a pilot study of our prospective study for adverse pregnancy outcomes by first-trimester screening. In the study the patient-specific first trimester risks of PE was calculated by a combination of maternal factors (age, ethnic origin, method of conception, body mass index (BMI), parity, smoking status, previous history of PE,mean arterial blood pressure (MAP)), mean UtA-PI and PAPP-A. PLGF was measured retrospectively from stored serum samples, and the risk was recalculated in each patient. Screen positive patients were determined by Astraia 2.8 program.ResultsBetween 2010-2012, 1112 women were recruited in the prospective study. Out of these, 75 cases were selected:17 cases of severe PE and 58 random control patients. The overall detection rate of severe PE 58.8% (10/17) did not improve by adding PLGF to the risk calculation, but the false positive rate decreased from 10,4% (6/58) without PLGF to 6,8% (4/58) with PLGF.ConclusionsCombination of these factors allows calculation of risk for PE in the first trimester. The detection rate (58,8%) of severe PE in our study is comparable with the published data. The contribution of PLGF to the screening efficacy was shown by the decreased false positive ratio. This reduction is not significant, our hypothesis must be tested on a larger sample of population. Further biochemical markers as angiogenetic factors measured in the first trimester might improve the detection rate.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Severe preeclampsia
Megjelenés:Ultrasound In Obstetrics & Gynecology 44 : S1 (2014), p. 270-270. -
További szerzők:Orosz Gergő Balázs (1985-) (szülész-nőgyógyász) Arany István Fábián Anna Pap Károly Medve László Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Török Olga (1956-) (szülész-nőgyógyász, humángenetikus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM068400
Első szerző:Orosz László (szülész-nőgyógyász)
Cím:Screening for pre-eclampsia during the first trimester in routine clinical practice : a prospective study / Orosz, L., Orosz, G., id. Orosz, L., Fabian, A., Tóth, Z., Török, O.
Dátum:2012
ISSN:0960-7692
Megjegyzések:ObjectivesThe association between pre-eclamsia (PE) and first trimester high uterine artery pulsatility index (UtA-PI), low maternal serum pregnancy-associated plasma protein-A (PAPP-A) level and certain maternal factors is well known. Several retrospective studies have shown that these first trimester markers can predict PE with a detection rate of 60?90%. The aim of this prospective study was to determine the performance of screening for PE in singleton pregnancies during routine clinical practice.MethodsBetween 2011?2012 measurements of UtA-PI were performed at 11?13 + 6 weeks, and mean pulsatility index (PI) was calculated. Doppler, maternal history and biometry variables (age, ethnic origin, method of conception, BMI, parity, smoking, family or personal history of hypertension or PE, blood pressure) were combined with first trimester PAPP-A to assess the risk of PE. Astraia Software 2.3.2 was used in risk calculation.Results2552 women were recruited after informed consent to the study, and outcome data were available in 950 (37.2%) cases. PE occurred in 36 (3.8%) patients. The overall detection rate of early and late PE was 44.4% (16/36) with a false positive rate (FPR) of 12.3% (112/914). There were only 2 cases with early PE, the detection rate was 50% (1/2), with a FPR of 18.7% (178/948). The detection rate of the late PE (delivery at 34th weeks or after) was 44.1% (15/34), with a FPR of 9.5% (87/914).ConclusionsCombining risk factors in the mother's history with UtA-PI allows calculation of patient-specific risk for the development of PE. Because of the small number of early PE cases in our study population our detection rate can not be taken into consideration. The detection rate (44%) of late PE in our study is comparable with the published retrospective data (60%). The Astraia software used only serum PAPP-A for risk calculation. Further biochemical markers might improve the detection rate. Follow-up of our recruited cases is still going on.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Screening for preeclampsia
Megjelenés:Ultrasound In Obstetrics & Gynecology. - 40 : S1 (2012), p. 199-200. -
További szerzők:Orosz Gergő Balázs (1985-) (szülész-nőgyógyász) id. Orosz László Fábián Anna Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Török Olga (1956-) (szülész-nőgyógyász, humángenetikus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1