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1.

001-es BibID:BIBFORM040310
Első szerző:Bakó József (vegyész)
Cím:Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery system / Jozsef Bako, Marta Szepesi, Adrienn J. Veres, Csaba Cserhati, Zsuzsa M. Borbely, Csaba Hegedus, Janos Borbely
Dátum:2008
ISSN:0303-402X
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Colloid And Polymer Science. - 286 : 3 (2008), p. 357-363. -
További szerzők:Szepesi Márta (1976-) (fogszakorvos) Veres Adrienn J. (biofizikus) Cserháti Csaba (1963-) (fizikus) Borbély Zsuzsa M. Hegedűs Csaba (1953-) (fogszakorvos) Borbély János (1950-) (vegyész)
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2.

001-es BibID:BIBFORM008968
Első szerző:Bodnár Magdolna
Cím:Preparation and characterization of cross-linked hyaluronan nanoparticles / Magdolna Bodnár, Lajos Daróczi, Gyula Batta, József Bakó, John F. Hartmann, János Borbély
Dátum:2009
Megjegyzések:The present investigation describes the synthesis and characterization of novel biodegradable nanoparticles based on hyaluronic acid (HA). The diamine, 2,2·(ethylenedioxy) bis(ethylamine) was used for cross-linking of the HA linear chains. The condensation reaction of amino groups and pendant carboxyl groups of HA was performed in aqueous media at room temperature using water-soluble carbodiimide. The prepared nanosystems, aqueous solutions, or dispersions of nanoparticles were stable, transparent, or mildly opalescent systems depending on the ratio of cross-linking, findings consistent with values of transmittance above 77%. The structure of products was determined by nuclear magnetic resonance spectroscopy, and the particle size was identified by laser light scattering (DLS) and transmission electron microscopy (TEM) measurements. Particle size measured by TEM varied less than 130 nm; in the swollen state, the average size of the particles measured by DLS was in the range of 30-140 nm depending on the ratio of cross-linking and the molecular weight of HA. Formation of cross-linked nanoparticles results in a viscosity drop compared to the viscosity of the corresponding solution of the HA, and this trend becomes decreasingly appreciable as the molecular weight of HA decreases.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekulatudomány
Hyaluronic acid
Nanoparticles
Cross-linking
Megjelenés:Colloid and Polymer Science. - 287 : 8 (2009), p. 991-1000. -
További szerzők:Daróczi Lajos (1965-) (fizikus) Batta Gyula (1953-) (molekula-szerkezet kutató) Bakó József (1981-) (vegyész) Hartmann, John F. Borbély János (1950-) (vegyész)
Pályázati támogatás:TÁMOP-4.2.2-08/1-2008-0019
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3.

001-es BibID:BIBFORM050117
Első szerző:Hajdu István (vegyész)
Cím:Nanoparticles prepared by self-assembly of Chitosan and poly-γ-glutamic acid / Istvan Hajdu, Magdolna Bodnár, Genovéva Filipcsei, John F. Hartmann, Lajos Daróczi, Miklós Zrínyi, János Borbély
Dátum:2007
ISSN:0303-402X
Megjegyzések:The present paper describes the preparation and characterization of novel biodegradable nanoparticles based on self-assembly of poly-gamma-glutamic acid (γ-PGA) and chitosan (CH). The nanosystems were stable in aqueous media at low pH conditions. Solubility of the systems was determined by turbidity measurements. Surface charge and mobility were measured electrophoretically. The particle size and the size distribution of the polyelectrolyte complexes were identified by dynamic light scattering and transmission electron microscopy (TEM). It was found that the size and size distribution of the nanosystems depends on the concentrations of γ-PGA and CH solutions and their ratio as well as on the pH of the mixture and the order of addition. The diameter of individual particles was in the range of 20-285 nm measured by TEM, and the average hydrodynamic diameters were between 150 and 330 nm. These biodegradable, self-assembling stable nanocomplexes might be useful for several biomedical applications.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
γ-PGA
Chitosan
Polyelectrolyte
Nanoparticles
Complexation
Self-assembly
Electrophoretic mobility
Megjelenés:Colloid and Polymer Science. - 286 : 3 (2007), p. 343-350. -
További szerzők:Bodnár Magdolna Filipcsei Genovéva Hartmann, John F. Daróczi Lajos (1965-) (fizikus) Zrínyi Miklós (kémikus) Borbély János (1950-) (vegyész)
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4.

001-es BibID:BIBFORM013449
Első szerző:Keczánné Üveges Andrea (vegyész)
Cím:Synthesis of crosslinked polymer nanoparticles suitable for the formation of nanolayer organic films / Andrea Uveges, John F. Hartmann, Lajos Daroczi, Janos Borbely
Dátum:2009
ISSN:0303-402X
Megjegyzések:Free radical crosslinking copolymerization of styrene and ethylene glycol dimethacrylate (nST/nEGDM in feed=5/5) has been investigated in toluene. Variation of the reaction conditions allows the formation of macromolecules with low molecular weight (21.6 kDa and 12 nm in diameter), perfectly soluble branched particles in the early stage of the polymerization. Elongation of the reaction time leads to the formation of soluble/swelling microgels with medium molecular weight (156 kDa and 41-120 nm) and, finally, swelling/particularly soluble colloidal polymer particles with very high molecular weight (3.6 MDa and 59?324 nm). Conversion, molecular weight [by gel permeation chromatography (GPC)], ratio of pendant vinyl groups [by nuclear magnetic resonance (NMR)], size of nanoparticles in swollen [by dynamic light scattering (DLS)] and dried state [by transmission electron microscopy (TEM)], morphology [by scanning electron microscopy (SEM)], and nanolayer film formation (by SEM) were measured. The role of reaction conditions in producing different polymer structures and morphologies was demonstrated.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Free radical polymerization
Nanoparticles
Nanolayer film formation
Megjelenés:Colloid and Polymer Science. - 287 : 4 (2009), p. 471-479. -
További szerzők:Hartmann, John F. Daróczi Lajos (1965-) (fizikus) Borbély János (1950-) (vegyész)
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5.

001-es BibID:BIBFORM049205
Első szerző:Keresztessy Zsolt
Cím:Self-assembling chitosan/poly-γ-glutamic acid nanoparticles for targeted drug delivery / Zsolt Keresztessy, Magdolna Bodnár, Elizabeth Ber, Istvan Hajdu, Min Zhang, John F. Hartmann, Tamara Minko, János Borbély
Dátum:2009
ISSN:0303-402X
Megjegyzések:For the purpose of targeted drug delivery,composite biodegradable nanoparticles were prepared fromchitosan and the poly-?-glutamic acid via an ionotropicgelation process. These stable self-assembled nanoparticleswere characterized by dynamic light scattering, transmissionelectron microscopy, and atomic force microscopy,which demonstrated that the nanosystem consists ofspherical particles with a smooth surface both in aqueousenvironment and in dried state. Toxicity measurementsshowed that the composition is nontoxic when tested eitheron cell cultures or in animal feeding experiments. Toevaluate the potential of the nanosystem for intracellulardrug delivery, the nanoparticles were fluorescently labeledand folic acid was attached as a cancer cell-specifictargeting moiety. The ability of the particles to beinternalized was tested using confocal microscopic imagingon cultured A2780/AD ovarian cancer cells, which overexpressfolate receptors. The quantitative data obtained bydigital processing of the intensity of green color of eachpixel in the pictures inside the cell boundaries and totalintensity of fluorescence inside the cells showed that"targeted" particles internalized into the cells significantlyfaster and the total accumulation of these particles wassubstantially higher in the cancer cells when compared with"nontargeted" particles, which may facilitate effective andspecific cytoplasmic delivery of anticancer agents loadedinto such nanoparticles.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
chitosan
PGA
nanoparticles
in vivo toxicity
Megjelenés:Colloid And Polymer Science. - 287 : 7 (2009), p. 759-765. -
További szerzők:Bodnár Magdolna Ber, Elizabeth Hajdu István (1981-) (vegyész) Zhang, Min Hartmann, John F. Minkó Tamara Borbély János (1950-) (vegyész)
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6.

001-es BibID:BIBFORM006969
Első szerző:Szalóki Melinda (vegyész)
Cím:Preparation of reactive polymeric nanoparticles (RPNPs) / Melinda Szaloki, Robert Skribanek, Zsolt Dudas, John F. Hartmann, Csaba Hegedűs, Janos Borbely
Dátum:2008
Megjegyzések:A series of reactive polymeric nanoparticles (RPNPs) was prepared by free radical nonlinear copolymerization of mono (M 1) and trivinyl acrylic (M 2) monomers in miniemulsion. The crosslinking density was determined by the mole ratio of the trivinyl component. It was found that the unswelled latex nanoparticles showed a narrower dispersity than in the organic solution of macromolecules. In latex, the size increased with the ratio of M 2 monomer due to its higher polarity in the aqueous medium. However, the swollen nanoparticles, dissolved or dispersed in organic solvent, showed a higher dispersity as a function of composition and the crosslinking density. The residual vinyl groups adjacent to the nanoparticles were subjected to further crosslinking reactions. The reactive vinyl groups were detected by nuclear magnetic resonance spectroscopy (NMR). The size of particles in swollen state was determined by dynamic laser light scattering (DLS) method and the dried form by scanning electron microscopy (SEM). It was found that size of RPNPs is in the range of 50 to 500 nm. These particles possess properties that may allow their application in areas as disparate as dental filling material and as a component in industrial powder-based coatings.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Free radical nonlinear polymerization
Reactive Polymeric Nanoparticles (RPNPs)
Miniemulsion
Number average vinyl functionality (NAVF)
Crosslinking polymerization
Megjelenés:Colloid and Polymer Science. - 286 : 4 (2008), p. 435-444. -
További szerzők:Skribanek Róbert Dudás Zsolt Hartmann, John F. Hegedűs Csaba (1953-) (fogszakorvos) Borbély János (1950-) (vegyész)
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