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001-es BibID:	BIBFORM103370
035-os BibID:	(Wos)000491345500001 (Scopus)85064527207 (Pubmed)30957461
Első szerző:	Csécsei Péter (neurológus)
Cím:	L-arginine pathway metabolites can discriminate paroxysmal from permanent atrial fibrillation in acute ischemic stroke / Csecsei Péter, Várnai Réka, Nagy Lajos, Kéki Sándor, Molnár Tihamér, Illés Zsolt, Farkas Nelli, Szapáry László
Dátum:	2019
ISSN:	0019-1442
Megjegyzések:	Background ? Atrial fibrillation (AF) is the most common arrhythmia diagnosed in clinical practice. We aimed to measure the L-arginine pathway metabolites as well as their ratios in patients with different types of AF or sinus rhythm and to explore the relationship among the markers and clinical variables in the subacute phase of acute ischemic stroke (AIS). Methods ? A total of 46 patients with AIS were prospectively enrolled. The patients were divided into three groups based on diagnosis of either sinus rhythm, paroxysmal or permanent AF. Plasma concentration of the L-arginine pathway metabolites were analyzed at post-stroke 24 hours in the three rhythm groups. Besides, clinical variables and laboratory data were recorded. Results ? Asymmetric dimetylarginine (ADMA) was significantly higher in patients with permanent AF compared to sinus rhythm (p<0.001). Both ADMA (p<0.001) and symmetric dimethylarginine (SDMA) (p<0.002) at 24 hours were significantly higher among patients with permanent AF compared to those with paroxysmal AF. The L-arginine/SDMA (p<0.031) ratios at 24 hours were significantly higher among patients with sinus rhythm compared to those with permanent AF. ROC analysis also revealed that plasma SDMA cut-off level over 0.639 ?mol/L discriminated permanent AF from paroxysmal AF or sinus rhythm with a 90.9% sensitivity and 77.1% specificity. Neutrophil-lymphocyte ratio also showed significantly higher value in individuals with both paroxysmal and permanent AF (p=0.029). Conclusions ? Plasma level of SDMA could discriminate permanent from paroxysmal AF in the subacute phase of ischemic stroke. In addition, an increased neutrophil-lymphocyte ratio may suggest inflammatory process in the evolution of atrial fibrillation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk L-arginine atrial fibrillation ischemic stroke
Megjelenés:	Ideggyógyászati Szemle. - 72 : 3-4 (2019), p. 79-88. -
További szerzők:	Várnai Réka Nagy Lajos (1979-) (vegyész) Kéki Sándor (1964-) (polimer kémikus) Molnár Tihamér (1992-) (általános orvos) Illés Zsolt (neurológus, Pécs) Farkas Nelli Szapáry László (1962-) (általános orvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM092482
Első szerző:	Molnár Tihamér (általános orvos)
Cím:	Methylarginine derivatives as early markers of endothelial dysfunction in asymptomatic carotid stenosis and acute ischemic stroke / T. Molnar, L. Nagy, S. Keki, G. Pusch, Z. Illes
Dátum:	2011
ISSN:	1351-5101
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	European Journal of Neurology. - 11 : Suppl. 2 (2011), p. 400-400. -
További szerzők:	Nagy Lajos (1979-) (vegyész) Kéki Sándor (1964-) (polimer kémikus) Pusch Gabriella Illés Zsolt (neurológus, Pécs)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM081479
Első szerző:	Ruzsics István
Cím:	L-Arginine Pathway in COPD Patients with Acute Exacerbation : A New Potential Biomarker / István Ruzsics, Lajos Nagy, Sándor Kéki, Veronika Sárosi, Balázs Illés, Zsolt Illés, Ildikó Horváth, Lajos Bogár, Tihamér Molnár
Dátum:	2016
ISSN:	1541-2555 1541-2563
Megjegyzések:	Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause of mortality. Clinical criteria of AECOPD are subjective. Biomarkers for AECOPD may aid in the initiation of early treatment. Increased production of asymmetric and symmetric dimethylarginine (ADMA, SDMA) is related to hypoxia. In COPD, a rise in ADMA results in a shift of L-arginine breakdown, contributing to airway obstruction. We aimed to compare serum levels of ADMA, SDMA and L-arginine in patients with and without AECOPD. Methods: L-arginine metabolites quantifi ed by high-performance liquid chromatography in venous blood samples and partial capillary oxygen pressure were prospectively investigated in 32 patients with COPD, 12 with AECOPD and 30 healthy subjects. Results: Both ADMA and SDMA were signifi cantly higher in AECOPD compared to stable COPD (p = 0.004 and p < 0.001, respectively). Oxygen content in capillaries correlated with serum ADMA concentration. However, the concentration of L-arginine was not different between AECOPD and stable COPD. Both ADMA and SDMA separated AECOPD with high sensitivity and specifi city (AUC: 0.81, p = 0.001; AUC: 0.91, p < 0.001, respectively). A cut-off value ?0.57 for SDMA was an independent variable to confi rm AECOPD in a regression model (OR: 1.632, p = 0.001). All markers were signifi cantly higher in the sera of both patient groups compared to the controls (p < 0.05, respectively). Conclusions: COPD is associated with elevated L-arginine, ADMA and SDMA serum levels. In patients with AECOPD, production of ADMA and SDMA are more pronounced presumably due to more severe hypoxic insult. Methylated arginine derivatives in the sera may help early recognition of AECOPD.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk asymmetric and symmetric dimethylarginine chronic obstructive pulmonary disease L-arginine
Megjelenés:	COPD Journal of Chronic Obstructive Pulmonary Disease. - 13 : 2 (2016), p. 139-145. -
További szerzők:	Nagy Lajos (1979-) (vegyész) Kéki Sándor (1964-) (polimer kémikus) Sárosi Veronika Illés Miklós Balázs Illés Zsolt (neurológus, Pécs) Horváth Ildikó (1964-) (tüdőgyógyász) Bogár Lajos Molnár Tihamér (1992-) (általános orvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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