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1.

001-es BibID:BIBFORM001011
Első szerző:Bányász Tamás (élettanász)
Cím:Action potencial clamp fingerprints of K+ currents in canine cardiomyocytes : their role in ventricular repolarization / Bányász T., Magyar J., Szentandrássy N., Horváth B., Birinyi P., Szentmiklósi J., Nánási P.
Dátum:2007
Megjegyzések:The aim of the present study was to give a parametric description of the most important K(+) currents flowing during canine ventricular action potential. METHODS: Inward rectifier K(+) current (I(K1)), rapid delayed rectifier K(+) current (I(Kr)), and transient outward K(+) current (I(to)) were dissected under action potential clamp conditions using BaCl(2), E-4031, and 4-aminopyridine, respectively. RESULTS: The maximum amplitude of I(to) was 3.0 +/- 0.23 pA/pF and its integral was 29.7 +/- 2.5 fC/pF. The current peaked 4.4 +/- 0.7 ms after the action potential upstroke and rapidly decayed to zero with a time constant of 7.4 +/- 0.6 ms. I(Kr) gradually increased during the plateau, peaked 7 ms before the time of maximum rate of repolarization (V(max)(-)) at -54.2 +/- 1.7 mV, had peak amplitude of 0.62 +/- 0.08 pA/pF, and integral of 57.6 +/- 6.7 fC/pF. I(K1) began to rise from -22.4 +/- 0.8 mV, peaked 1 ms after the time of V(max)(-) at -58.3 +/- 0.6 mV, had peak amplitude of 1.8 +/- 0.1 pA/pF, and integral of 61.6 +/- 6.2 fC/pF. Good correlation was observed between peak I(K1) and V(max)(-) (r = 0.93) but none between I(Kr) and V(max)(-). Neither I(K1) nor I(Kr) was frequency-dependent between 0.2 and 1.66 Hz. Congruently, I(Kr) failed to accumulate in canine myocytes at fast driving rates. CONCLUSION: Terminal repolarization is dominated by I(K1), but action potential duration is influenced by several ion currents simultaneously. As I(to) was not active during the plateau, and neither I(K1) nor I(Kr) was frequency-dependent, other currents must be responsible for the frequency dependence of action potential duration at normal and slow heart rates in canine ventricular cells.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Physiologica (Oxford, England). - 190 : 3 (2007), p. 189-198. -
További szerzők:Magyar János (1961-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Horváth Balázs (1981-) (élettanász) Birinyi Péter (1981-) (élettanász) Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos) Nánási Péter Pál (1956-) (élettanász)
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DOI
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2.

001-es BibID:BIBFORM030493
035-os BibID:WOS:A1987G900700003
Első szerző:Cseri Julianna (laboratóriumi diagnosztika szakorvos)
Cím:Effects of phlorizin and phloretin on passive and dynamic electrical properties in muscle membrane / Júlia Cseri, P. P. Nanasi, E. Varga
Dátum:1987
ISSN:0231-424X
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Physiologica Hungarica. - 69 : 1 (1987), p. 21-32. -
További szerzők:Nánási Péter Pál (1956-) (élettanász) Varga E.
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3.

001-es BibID:BIBFORM036997
Első szerző:Farkas Viktória
Cím:Interaction between Ca2+ channel blockers and isoproterenol on L-type Ca2+ current in canine ventricular cardiomyocytes / Farkas Viktória, Szentandrássy Norbert, Bárándi László, Hegyi Bence, Ruzsnavszky Ferenc, Ruzsnavszky Olga, Horváth Balázs, Bányász Tamás, Magyar János, Márton Ildikó, Nánási Péter P.
Dátum:2012
ISSN:1748-1708
Megjegyzések:The aim of this work was to study antagonistic interactions betweenthe effects of various types of Ca2+ channel blockers and isoproterenol onthe amplitude of L-type Ca2+ current in canine ventricular cells.Methods: Whole-cell version of the patch clamp technique was used tostudy the effect of isoproterenol on Ca2+ current in the absence and presenceof Ca2+ channel?blocking agents, including nifedipine, nisoldipine,diltiazem, verapamil, CoCl2 and MnCl2.Results: Five micromolar Nifedipine, 1 lM nisoldipine, 10 lM diltiazem,5 lM verapamil, 3 mM CoCl2 and 5 mM MnCl2 evoked uniformly a 90?95% blockade of Ca2+ current in the absence of isoproterenol. Isoproterenol(100 nM) alone increased the amplitude of Ca2+ current from6.8 ? 1.3 to 23.7 ? 2.2 pA/pF in a reversible manner. Isoproterenol causeda marked enhancement of Ca2+ current even in the presence of nifedipine,nisoldipine, diltiazem and verapamil, but not in the presence of CoCl2 orMnCl2.Conclusion: The results indicate that the action of isoproterenol is differentin the presence of organic and inorganic Ca2+ channel blockers. CoCl2and MnCl2 were able to fully prevent the effect of isoproterenol on Ca2+current, while the organic Ca2+ channel blockers failed to do so. This hasto be born in mind when the effects of organic Ca2+ channel blockers areevaluated either experimentally or clinically under conditions of increasedsympathetic tone.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekuláris Medicina
Megjelenés:Acta Physiologica. - 206 : 1 (2012), p. 42-50. -
További szerzők:Szentandrássy Norbert (1976-) (élettanász) Bárándi László (1984-) (élettanász) Hegyi Bence (1987-) (élettanász) Ruzsnavszky Ferenc (1984-) (élettanász) Ruzsnavszky Olga (1983-) (élettanász) Horváth Balázs (1981-) (élettanász) Bányász Tamás (1960-) (élettanász) Magyar János (1961-) (élettanász) Márton Ildikó (1954-) (fogszakorvos) Nánási Péter Pál (1956-) (élettanász)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
A feszültségfüggő K-csatornák szerepe excitábilis sejtekben
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4.

001-es BibID:BIBFORM030250
035-os BibID:WOS:000182475600002
Első szerző:Fülöp László (kardiológus)
Cím:Differences in electrophysiological and contractile properties of mammalian cardiac tissues bathed in bicarbonate - and HEPES-buffered solutions / L. Fülöp, G. Szigeti, J. Magyar, N. Szentandrássy, T. Ivanics, Z. Miklós, L. Ligeti, A. Kovács, G. Szénási, L. Csernoch, P. P. Nánási, T. Bányász
Dátum:2003
ISSN:0001-6772
Megjegyzések:Aim: The aim of this study was to compare the action potential configuration, contractility, intracellular Ca2+ and H+ concentrations in mammalian cardiac tissues bathed with Krebs and Tyrode solutions at 37 degreesC. Results: In Langendorff-perfused guinea-pig hearts, loaded with the fluorescent Ca2+ -indicator Fura-2, or H+ -sensitive dye carboxy-SNARF, shifts from Krebs to Tyrode solution caused intra-cellular acidification, increased diastolic pressure and [Ca2+ ](i) , decreased systolic pressure and [Ca2+ ](i) , leading to a reduction in the amplitude of [Ca2+ ](i) transients and pulse pressure. Contractility was also depressed in canine ventricular trabeculae when transferred from Krebs to Tyrode solution. Shifts from Krebs to Tyrode solution increased the duration of action potentials in multicellular cardiac preparations excised from canine and rabbit hearts but not in isolated cardiomyocytes. All these changes in action potential morphology, contractility, [Ca2+ ](i) and [H+ ](i) were readily reversible by addition of 26 mmol L-1 bicarbonate to Tyrode solution. Effects of dofetilide and CsCl, both blockers of the delayed rectifier K current, on action potential duration were compared in Krebs and Tyrode solutions. Dofetilide lengthened rabbit ventricular action potentials in a significantly greater extent in Tyrode than in Krebs solution. Exposure of canine Purkinje fibres to CsCl evoked early after depolarizations within 40 min in all preparations incubated with Tyrode solution, but not in those bathed with Krebs solution. Conclusion: It is concluded that the marked differences in action potential morphology, [Ca2+ ](i) , [H+ ](i) and contractility observed between preparations bathed with Krebs and Tyrode solutions are more likely attributable to differences in the intracellular buffering capacities of the two media.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Physiologica Scandinavica. - 178 : 1 (2003), p. 11-18. -
További szerzők:Szigeti Gyula (1969-) (élettanász, elektrofiziológus) Magyar János (1961-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Ivanics Tamás Miklós Zsuzsanna Ligeti László Kovács A. Szénási Gábor Csernoch László (1961-) (élettanász) Nánási Péter Pál (1956-) (élettanász) Bányász Tamás (1960-) (élettanász)
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5.

001-es BibID:BIBFORM030248
035-os BibID:WOS:000187850300006
Első szerző:Fülöp László (kardiológus)
Cím:Reopening of L-type calcium channels in human ventricular myocytes during applied epicardial action potentials / L. Fülöp, T. Bányász, J. Magyar, N. Szentandrássy, A. Varró, P. P. Nánási
Dátum:2004
ISSN:0001-6772
Megjegyzések:Aims: Present study was performed to compare the dynamics of human L-type calcium current (I-Ca,I-L) flowing during rectangular voltage pulses, voltage ramps, and action potentials (APs) recorded from epicardiac and endocardiac canine ventricular cells. Methods: I-Ca,I-L was recorded in single myocytes isolated from undiseased human hearts using the whole cell voltage clamp technique. Results: The decay of I-Ca,I-L was monotonic when using rectangular pulses or endocardial APs as voltage commands, whereas the current became double-peaked (displaying a second rise and fall) during epicardial (EPI) APs or voltage ramps used to mimic EPI APs. These I-Ca,I-L profiles were associated with single-hooked and double-hooked phase-plane trajectories, respectively. No sustained current was observed during the AP commands. Kinetics of deactivation and recovery from inactivation of human I-Ca,I-L were determined using twin-pulse voltage protocols and voltage ramps, and the results were similar to those obtained previously in canine cells under identical experimental conditions. Conclusions: I-Ca,I-L can inactivate partially before and deactivate during the phase-1 repolarization of the epicardiac AP, and reopening of these channels seems to be associated with formation of the dome.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Physiologica Scandinavica. - 180 : 1 (2004), p. 39-47. -
További szerzők:Bányász Tamás (1960-) (élettanász) Magyar János (1961-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Varró András (1954-) (farmakológus, klinikai farmakológus) Nánási Péter Pál (1956-) (élettanász)
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6.

001-es BibID:bibEBI00018654
Első szerző:Fülöp László (kardiológus)
Cím:Effects of sex hormones on ECG parameters and expression of cardiac ion channels in dogs / Fülöp L., Bányász T., Szabó G., Tóth I. B., Bíró T., Lőrincz I., Balogh A., Pető K., Mikó I., Nánási P. P.
Dátum:2006
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Physiologica. - 188 : 3-4 (2006), p. 163-171. -
További szerzők:Bányász Tamás (1960-) (élettanász) Szabó G. Tóth István Balázs (1978-) (élettanász) Bíró Tamás (1968-) (élettanász) Lőrincz István (1950-) (belgyógyász, kardiológus) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Pető Katalin (1961-) (kutatóorvos) (Kísérletes orvostudomány) Mikó Irén (1948-) (kutató sebész) Nánási Péter Pál (1956-) (élettanász)
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7.

001-es BibID:BIBFORM110028
035-os BibID:(WOS)000852987800102
Első szerző:Horváth Balázs (élettanász)
Cím:Role of protein kinase A and calcium/calmodulin-dependent protein kinase II in beta-adrenergic regulation of potassium channels / Horvath B., Kiss D., Hezso T., Veress R., Dienes C., Kovacs Z., Szentandrassy N., Magyar J., Banyasz T., Nanasi P.
Dátum:2022
ISSN:1748-1708
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Acta Physiologica. - 236 : S725 (2022), p. 103-105. -
További szerzők:Kiss Dénes Zsolt (1995-) (orvos, élettanász) Hézső Tamás (1993-) (élettanász) Veress Roland (1992-) (molekuláris biológus) Dienes Csaba (1995-) (gyógyszerész) Kovács Zsigmond Máté (1995-) (orvos) Szentandrássy Norbert (1976-) (élettanász) Magyar János (1961-) (élettanász) Bányász Tamás (1960-) (élettanász) Nánási Péter Pál (1956-) (élettanász)
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8.

001-es BibID:BIBFORM009079
Első szerző:Lengyel Csaba (Szeged)
Cím:Role of slow delayed rectifier K+-current in QT prolongation in the alloxan-induced diabetic rabbit heart / Lengyel, C., Virag, L., Kovacs, P. P., Kristof, A., Pacher, P., Kocsis, E., Koltay, Z. M., Nanasi, P. P., Toth, M., Kecskemeti, V., Papp, J. G., Varro, A., Jost, N.
Dátum:2008
ISSN:1748-1716 (Electronic)
Megjegyzések:In diabetes mellitus, several cardiac electrophysiological parameters are known to be affected. In rodent experimental diabetes models, changes in these parameters were reported, but only limited relevant information is available in other species, having cardiac electrophysiological properties more resembling the human, including the rabbit. The present study was designed to analyse the effects of experimental type 1 diabetes on ventricular repolarization and the underlying transmembrane potassium currents in rabbit hearts. METHODS: Diabetes was induced by a single injection of alloxan (145 mg kg(-1) i.v.). After the development of diabetes (3 weeks), electrophysiological studies were performed using whole cell voltage clamp and ECG measurements. RESULTS: The QT(c) interval in diabetic rabbits was moderately but statistically significantly longer than measured in the control animals (155 +/- 1.8 ms vs. 145 +/- 2.8 ms, respectively, n = 9-10, P < 0.05). This QT(c)-lengthening effect of diabetes was accompanied by a significant reduction in the density of the slow delayed rectifier K(+) current, I(Ks) (from 1.48 +/- 0.35 to 0.86 +/- 0.17 pA pF(-1) at +50 mV, n = 19-21, P < 0.05) without changes in current kinetics. No differences were observed either in the density or in the kinetics of the inward rectifier K(+) current (I(K1)), the rapid delayed rectifier K(+) current (I(Kr)), the transient outward current (I(to)) and the L-type calcium current (I(CaL)) between the control and alloxan-treated rabbits. CONCLUSION: It is concluded that type 1 diabetes mellitus, although only moderately, lengthens ventricular repolarization. Diabetes attenuates the repolarization reserve by decreasing the density of I(Ks) current, and thereby may enhance the risk of sudden cardiac death.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Alloxan
Animals
Delayed Rectifier Potassium Channels
Diabetes Mellitus, Experimental
Electrocardiography
Heart
Heart Conduction System
Heart Ventricles
Long QT Syndrome
Male
Patch-Clamp Techniques
Rabbits
Megjelenés:Acta Physiologica (Oxford, England). - 192 : 3 (2008), p. 359-368. -
További szerzők:Virág László (élettanász Szeged) Kovacs Péter Pál (Szeged) Kristóf A. (Szeged) Pacher Pál Kocsis E. Koltay Zs. M. Nánási Péter Pál (1956-) (élettanász) Tóth M. Kecskeméti Valéria Papp Gy. Julius (Szeged) Varró András (1954-) (farmakológus, klinikai farmakológus) Jost Norbert
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elektronikus változat
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9.

001-es BibID:BIBFORM030356
035-os BibID:PMID:1668707 WOS:A1991JM65600007
Első szerző:Nánási Péter Pál (élettanász)
Cím:Slow membrane potential changes in skeletal muscle induced in Cl(-)-free medium / P. P. Nanasi, M. Danko
Dátum:1991
ISSN:0231-424X
Megjegyzések:1. Conventional microelectrode techniques were used to measure simultaneous changes in membrane potential (V(m)) and conductance (G(m)) induced by single electrical stimuli in muscles bathed in Cl--free solution containing 40 mM of tetraethylammonium (TEA+). 2. Stimulation induced slow transient depolarizations (slow response) accompanied by increased calcium conductance, while the potassium conductance was first elevated and later reduced. 3. Stepwise elevation of [K+]0 from 2.5 to 5 or 10 mM during the slow response evoked an abrupt repolarization of 42.3 +/- 8.9 mV (n = 4; p < 0.001), and 24.8 +/-3.5 +/- mV (n = 5; p < 0.001), respectively, while G(m) was increased to 1.45 +/- 0.25-fold (n = 5; p < 0.05). Neither the slow response nor K+-induced changes in V(m) or G(m) were sensitive to tetrodotoxin (3-mu-M), however, nifedipine (10-mu-M) abolished the slow response. 4. It was concluded that beyond the increase of calcium conductance, the ionic conductance of the inward rectifier K+ channel was reduced during the slow response, which could be restored by the elevation of [K+]0. The results suggest the possible contribution of these mechanisms to the electrical instability of myotonic muscles. Potential therapeutic consequences are discussed.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Physiologica Hungarica. - 78 : 4 (1991), p. 369-377. -
További szerzők:Dankó Miklós
Pályázati támogatás:1453
OTKA
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10.

001-es BibID:BIBFORM030339
035-os BibID:PMID: 8899061 WOS:A1996VL12100005
Első szerző:Nánási Péter Pál (élettanász)
Cím:Electrical restitution in rat ventricular muscle / P. P. Nanasi, Cs. Pankucsi, T. Banyasz, P. Szigligeti, J. Gy. Papp, A. Varro
Dátum:1996
ISSN:0001-6772
Megjegyzések:The mechanism of electrical restitution was studied in isolated rat ventricular muscle using drugs that inhibit specific ion currents. The effect of transient changes in cytosolic Ca concentration and Na/Ca exchange in relation to the restitution process was also studied in single ventricular cardiomyocytes. Conventional microelectrode techniques were applied to record action potentials having gradually increasing coupling intervals. each evoked following a train of stimuli with a frequency of 1 Hz. ion currents were recorded from enzymatically isolated cells using the whole cell parch clamp technique. Ca transients were monitored in myocytes loaded with the fluorescent dye, indo-1. The electrical restitution process in multicellular rat ventricular preparations at 37 degrees C was described as a sum oi three exponential components: an early positive component. a subsequent fast negative component and a late negative component. having time constants of 21.9 +/- 1.9, 73.1 +/- 6.0 and 1053 +/- 61 ms, respectively (n = 9). Inhibition of the transient outward K current the delayed rectifier K current. or the chloride current did not substantially alter these time constants, The early positive and fast negative components were fully abolished by nifedipine or MnCl2. In the presence of caffeine. the fast negative component was absent. while the time constant of the early positive component increased to 39.5 +/- 5.8 ms (n = 5). In single myocytes loaded with indo-1, the Ca transients decayed with a time constant of 151 +/- 12 ms at room temperature (n = 5). These Ca transients were accompanied by inward current tails. identified as a Na/Ca exchange current. having a decay time constant of 140 +/- 4.5 ms. It is concluded that electrical restitution in rat ventricular muscle is relatively little affected by recovery from voltage-dependent inactivation of ion channels. it is rather governed by transient changes in cytosolic Ca concentration possible via Ca-dependent inactivation of the L-type Ca current and activation of the Na/Ca exchange current.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Physiologica Scandinavica. - 158 : 2 (1996), p. 143-153. -
További szerzők:Pankucsi Csaba (farmakológus) Bányász Tamás (1960-) (élettanász) Szigligeti Péter Papp Gy. Julius (Szeged) Varró András (1954-) (farmakológus, klinikai farmakológus)
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11.

001-es BibID:BIBFORM030273
Első szerző:Pacher Pál
Cím:Electrophysiological changes in rat ventricular and atrial myocardium at different stages of experimental diabetes / P. Pacher, Z. Ungvari, P. P. Nanasi, V. Kecskemeti
Dátum:1999
ISSN:0001-6772
Megjegyzések:Action potential configuration in ventricular and atrial myocardium, as well as rate-dependent changes in ventricular action potential duration (APD) were studied and compared in healthy and diabetic rats. Diabetes was induced by a single injection of streptozotocin (STZ, 65 mg kg(-1) i.v.). Conventional microelectrode techniques were applied to record action potentials after the establishment of diabetes (2, 6, 10 and 18 weeks after STZ-treatment). Untreated age-matched animals were used as controls. Both depolarization and repolarization were significantly retarded following STZ-treatment. However, the time course of development of diabetic changes in atrial and ventricular myocardium was different. APD was significantly lengthened from week 2 of diabetes in ventricular; but only from week 6 in atrial preparations. In atrial myocardium. lengthening of APD was more pronounced at early rather than late phases of repolarization.,The maximum rate of depolarization (V-max) was significantly reduced from the 6th week of diabetes in both preparations. No differences were observed in action potential amplitude (except at week 18) and in the resting membrane potential in diabetic rats. Diabetic ventricular preparations showed a positive APD-frequency relationship at any level of repolarization. in contrast to control muscles, where APD(25) and APD(50) values lengthened. But APD(75) and APD(90) values were not changed significantly with increase in the pacing frequency. The results indicate that development of diabetic alterations are not fully identical in atrial and ventricular myocardium of the rat, probably owing to differences in density and kinetics of ionic currents responsible for atrial and ventricular action potentials.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Physiologica Scandinavica. - 166 : 1 (1999), p. 7-13. -
További szerzők:Ungvári Zoltán Nánási Péter Pál (1956-) (élettanász) Kecskeméti Valéria
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12.

001-es BibID:BIBFORM030272
Első szerző:Pacher Pál
Cím:Post-partum prolongation of the atrial repolarization in rabbit / P. Pacher, Z. Ungvari, P. P. Nanasi, I. Mucha, V. Kecskemeti, Gy. Losonczy
Dátum:1999
ISSN:0001-6772
Megjegyzések:Female sexual steroids are known to modify the expression of various K+ channels and thus they can alter cardiac repolarization. In the present work, using conventional microelectrode techniques, action potential characteristics were studied in atrial myocardium isolated from virgin, late pregnant, early (1-3 days) post-partum and late (2-3 weeks) post-partum rabbits. No changes in action potential configuration were observed during pregnancy. However, the duration, overshoot and amplitude of action potentials were significantly increased in the early (1-3 days) post-partum period. Resting potential and maximum rate of depolarization remained unchanged. The observed changes were transient, normal action potential characteristics were obtained at weeks 2-3 post-partum. 4-aminopyridine (1 mmol L-1). caused a marked lengthening of action potential duration in all preparations obtained from non-pregnant and pregnant rabbits, whereas this 4-aminopyridine-induced prolongation was moderate in those preparations excised from the hearts of early post-partum animals. Action potential configuration was not affected by pinacidil (10 mu mol L-1) or glibenclamide (5 mu mol L-1) in non-pregnant or pregnant animals. In preparations obtained from early post-partum rabbits, pinacidil significantly shortened action potential duration, which was reverted by glibenclamide. The lengthening of action potential duration together with the decreased sensitivity to 4-aminopyridine observed in early post-partum animals may probably be caused by reduction of the transient outward K+ current at this stage. The results also suggest that electrophysiological alterations in the early post-partum period may probably be more pronounced than those associated with pregnancy itself.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Physiologica Scandinavica. - 166 : 1 (1999), p. 1-5. -
További szerzők:Ungvári Zoltán Nánási Péter Pál (1956-) (élettanász) Mucha, I. Kecskeméti Valéria Losonczy György
Internet cím:elektronikus változat
Intézményi repozitóriumban (DEA) tárolt változat
DOI
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