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001-es BibID:	BIBFORM101574
035-os BibID:	(cikkazonosító)864002 (WOS)000778821700001 (Scopus)85127785929
Első szerző:	Horváth Balázs (élettanász)
Cím:	Exploring the Coordination of Cardiac Ion Channels With Action Potential Clamp Technique / Balázs Horváth, Norbert Szentandrássy, Csaba Dienes, Zsigmond M. Kovács, Péter P. Nánási, Ye Chen-Izu, Leighton T. Izu, Tamas Banyasz
Dátum:	2022
ISSN:	1664-042X
Megjegyzések:	The patch clamp technique underwent continual advancement and developed numerous variants in cardiac electrophysiology since its introduction in the late 1970s. In the beginning, the capability of the technique was limited to recording one single current from one cell stimulated with a rectangular command pulse. Since that time, the technique has been extended to record multiple currents under various command pulses including action potential. The current review summarizes the development of the patch clamp technique in cardiac electrophysiology with special focus on the potential applications in integrative physiology.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cardiac electrophysiology voltage clamp action potential voltage clamp ion current pharmacology
Megjelenés:	Frontiers in Physiology. - 13 (2022), p. 864002. -
További szerzők:	Szentandrássy Norbert (1976-) (élettanász) Dienes Csaba (1995-) (gyógyszerész) Kovács Zsigmond Máté (1995-) (orvos) Nánási Péter Pál (1956-) (élettanász) Chen-Izu, Ye Izu, Leighton T. Bányász Tamás (1960-) (élettanász)
Pályázati támogatás:	OTKA-115397 OTKA K138090 OTKA FK128116 OTKA GINOP-2.3.2-15-2016-00040 GINOP EFOP-3.6.2-16-2017-00006 EFOP TKP-2020-NKA-04 Egyéb EFOP-3.6.3-VEKOP-16-2017-00009 EFOP ÚNKP-21-3 Egyéb
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001-es BibID:	BIBFORM083000
035-os BibID:	(cikkazonosító)1547 (WoS)000508451400002 (Scopus)85078809657
Első szerző:	Sampedro-Puente, David Adolfo
Cím:	Time Course of Low-Frequency Oscillatory Behavior in Human Ventricular Repolarization Following Enhanced Sympathetic Activity and Relation to Arrhythmogenesis / David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, Norbert Szentandrássy, Péter Nánási, Peter Taggart, Esther Pueyo
Dátum:	2020
ISSN:	1664-042X
Megjegyzések:	Background and Objectives: Recent studies in humans and dogs have shown that ventricular repolarization exhibits a low-frequency (LF) oscillatory pattern following enhanced sympathetic activity, which has been related to arrhythmic risk. The appearance of LF oscillations in ventricular repolarization is, however, not immediate, but it may take up to some minutes. This study seeks to characterize the time course of the action potential (AP) duration (APD) oscillatory behavior in response to sympathetic provocations, unveil its underlying mechanisms and establish a potential link to arrhythmogenesis under disease conditions. Materials and Methods: A representative set of human ventricular computational models coupling cellular electrophysiology, calcium dynamics, ?-adrenergic signaling, and mechanics was built. Sympathetic provocation was modeled via phasic changes in ?-adrenergic stimulation (?-AS) and mechanical stretch at Mayer wave frequencies within the 0.03?0.15 Hz band. Results: Our results show that there are large inter-individual differences in the time lapse for the development of LF oscillations in APD following sympathetic provocation, with some cells requiring just a few seconds and other cells needing more than 3 min. Whereas, the oscillatory response to phasic mechanical stretch is almost immediate, the response to ?-AS is much more prolonged, in line with experimentally reported evidences, thus being this component the one driving the slow development of APD oscillations following enhanced sympathetic activity. If ?-adrenoceptors are priorly stimulated, the time for APD oscillations to become apparent is remarkably reduced, with the oscillation time lapse being an exponential function of the pre-stimulation level. The major mechanism underlying the delay in APD oscillations appearance is related to the slow IKs phosphorylation kinetics, with its relevance being modulated by the IKs conductance of each individual cell. Cells presenting short oscillation time lapses are commonly associated with large APD oscillation magnitudes, which facilitate the occurrence of pro-arrhythmic events under disease conditions involving calcium overload and reduced repolarization reserve. Conclusions: The time course of LF oscillatory behavior of APD in response to increased sympathetic activity presents high inter-individual variability, which is associated with different expression and PKA phosphorylation kinetics of the IKs current. Short time lapses in the development of APD oscillations are associated with large oscillatory magnitudes and pro-arrhythmic risk under disease conditions.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk low-frequency oscillations beta-adrenergic stimulation cardiac cell models ventricular repolarization sympathetic activity arrhythmogenesis
Megjelenés:	Frontiers in Physiology. - 10 (2020), p. 1547. -
További szerzők:	Fernandez-Bes, Jesus Szentandrássy Norbert (1976-) (élettanász) Nánási Péter Pál (1956-) (élettanász) Taggart, Peter Pueyo, Esther
Pályázati támogatás:	GINOP-2.3.2.-15-2016-00040 GINOP EFOP-3.6.2-16-2017-00006 EFOP NKFIH-K115397 NKFIH
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