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1.

001-es BibID:BIBFORM030274
035-os BibID:WOS:000079560700007
Első szerző:Bányász Tamás (élettanász)
Cím:EGIS-7229, the new combined class III antiarrhythmic agent : lack of EAD inducing effect / Tamás Bányász, János Magyar, András Varró, Anikó Kovács, Ildikó Gyönös, Gábor Szénási, Péter P. Nánási
Dátum:1999
ISSN:0306-3623
Megjegyzések:EGIS-7229 is a novel antiarrhythmic candidate having multiple mechanisms of action with class III predominance. In this study, the effects of EGIS-7229 and sotalol on action potential duration (APD) and incidence of early afterdepolarizations (EADs) were studied and compared in rabbit papillary muscle by using conventional microelectrode techniques. In control bathing solution, both drugs increased APD in a concentration-dependent manner; however, the prolongation of APD was greater with sotalol than with EGIS-7229 when the same drug concentrations were compared. EAD developed in 3 of the 11 preparations (27%) bathed with a solution containing 3.6 mmol/l CsCl + 2 mmol/l KCl within the first 120 min of superfusion. The addition of 100 mu mol/l sotalol to this superfusate increased the incidence of EAD to 83% (10 from 12), whereas the addition of the same concentration of EGIS-7229 prevented the development of EAD in all of the 9 preparations studied. These differences in incidence of EAD are likely attributable to differences in drug-induced increases of APD-50 in the presence of CsCl. Prolongation of APD-90 showed less correlation with incidence of EAD than changes in APD-50. On the basis of these in vitro results, high concentrations of EGIS-7229 cannot be expected to be torsadogenic in vivo-in contrast with sotalol-presumably owing to the combined class III + IV activity of the compound. (C) 1999 Elsevier Science Inc. All rights reserved.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 32 : 3 (1999), p. 329-333. -
További szerzők:Magyar János (1961-) (élettanász) Varró András (1954-) (farmakológus, klinikai farmakológus) Kovács Anikó Gyönös Ildikó Szénási Gábor Nánási Péter Pál (1956-) (élettanász)
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2.

001-es BibID:BIBFORM030263
035-os BibID:WOS:000168774300010
Első szerző:Jednákovits Andrea
Cím:In vivo and in vitro acute cardiovascular effects of bimoclomol / Andrea Jednákovits, Péter Ferdinándy, László Jaszlits, Tamás Bányász, János Magyar, Péter Szigligeti, Ágnes Körtvély, József A. Szentmiklósi, Péter P. Nánási
Dátum:2000
ISSN:0306-3623
Megjegyzések:Effects of bimoclomol, the novel heat shock protein (HSP) coinducer, was studied in various mammalian cardiac and rabbit aortic preparations. Bimoclomol decreased the ST-segment elevation induced by coronary occlusion in anesthetized dogs (56% and 80% reduction with 1 and 5 mg/kg, respectively). In isolated working rat hearts, bimoclomol increased coronary now (CF), decreased the reduction of cardiac output (CO) and left ventricular developed pressure (LVDP) developing after coronary occlusion, and prevented ventricular fibrillation (VF) during reperfusion. In rabbit aortic preparations, precontracted with phenylephrine, bimoclomol induced relaxation (EC50=214 muM). Bimoclomol produced partial relaxation against 20 mM KCl, however, bimoclomol failed to relax preparations precontracted with serotonin, PGF(2) or angiotensin II. All these effects were evident within a few minutes after application of bimoclomol. A rapid bimoclomol-induced compartmental translocation of the already preformed HSPs may explain the protective action of the compound. (C) 2001 Elsevier Science Inc. All rights reserved.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology-the Vascular System. - 34 : 5 (2000), p. 363-369. -
További szerzők:Ferdinándy Péter Jaszlits László Bányász Tamás (1960-) (élettanász) Magyar János (1961-) (élettanász) Szigligeti Péter Körtvély Ágnes Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos) Nánási Péter Pál (1956-) (élettanász)
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3.

001-es BibID:BIBFORM030499
035-os BibID:PMID:2279686 WOS:A1990EB78600008
Első szerző:Nánási Péter Pál (élettanász)
Cím:Different actions of aconitine and veratrum alkaloids on frog skeletal muscle / Péter P. Nanasi, Tamás Kiss, Miklós Danko, David A. Lathrop
Dátum:1990
ISSN:0306-3623
Megjegyzések:1. The electrophysiological effects of veratridine, cevadine and aconitine (10(-8)-2 x 10(-4), 2 x 10(-7)-2 x 10(-6) and 2 x 10(-6)-10(-4) mol/l, respectively) were compared on frog muscle membrane using conventional microelectrodes. 2. Veratridine and aconitine were equally effective in depolarizing the resting membrane with the threshold concentration of 5 x 10(-5) mol/l. 3. Volleys of repetitive discharges and slow transient depolarizations were observed when single electrical stimuli were applied in the presence of veratridine (5 x 10(-8)-2 x 10(-5) mol/l), but not aconitine. Volleys with aconitine could be evoked only by repetitive stimulation; however no tendency of repolarization was observed following these volleys. Two orders of magnitude more aconitine than veratridine was required to induce volleys with similar parameters. 4. The effects of cevadine were similar to those of the corresponding concentrations of veratridine. 5. The observed differences between the electrophysiological actions of aconitine and veratrum alkaloids may be explained in part with differences in Na+ channel inactivation produced by these toxins, in addition to differences in their use-dependent behavior.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 21 : 6 (1990), p. 863-868. -
További szerzők:Kiss Tamás Dankó Miklós Lathrop, David A.
Pályázati támogatás:2/666/88
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4.

001-es BibID:BIBFORM030352
035-os BibID:PMID:1356876 WOS:A1992JF22300027
Első szerző:Nánási Péter Pál (élettanász)
Cím:Biphasic effect of tetraethylammonium on canine purkinje fibre action potential configuration / Péter P. Nanasi, Timothy K. Knilans, Ira S. Richards, András Varro, David A. Lathrop
Dátum:1992
ISSN:0306-3623
Megjegyzések:1. Using conventional microelectrode techniques a biphasic effect of tetraethylammonium (5 mmol/l) on the configuration of action potentials recorded from isolated canine Purkinje fibres: action potentials were first shortened (early effect) and then lengthened (late effect) by tetraethylammonium. 2. The early effect of tetraethylammonium also included lengthening of phase 1 duration and elevation of the plateau amplitude. These early effects reached steady-state within the first 3 min of superfusion and were readily reversed within 3 min of initiating washout of the drug. 3. The late effect (gradual lengthening of repolarisation during phase 3) failed to reach steady-state within the initial 60 min of superfusion and was not reversible. 4. The early effects of tetraethylammonium were more marked at slow driving rates and were not affected by blockade of alpha- and beta-adrenoceptors using 1-mu-mol/l phentolamine and 1-mu-mol/l propranolol. 5. The early effects of tetraethylammonium were mimicked by 4-aminopyridine (0.5 mmol/l), and in the presence of 4-aminopyridine tetraethylammonium failed to induce further changes in action potential morphology. 6. The early effects of tetraethylammonium may be due to inhibition of the transient outward current. 7. The rapid onset and reversibility of these early effects suggest that tetraethylammonium may act from outside the cell membrane.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:General Pharmacology. - 23 : 4 (1992), p. 733-738. -
További szerzők:Knilans, Timothy K. Richards, Ira S. Varró András (1954-) (farmakológus, klinikai farmakológus) Lathrop, David A.
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5.

001-es BibID:BIBFORM030345
035-os BibID:PMID:7721043 WOS:A1994QF05100018
Első szerző:Nánási Péter Pál (élettanász)
Cím:Effects of veratridine on Na and Ca currents in frog skeletal muscle / Péter P. Nanasi, András Varro, David A. Lathrop, Sirley H. Bryant
Dátum:1994
ISSN:0306-3623
Megjegyzések:1. Voltage-clamp experiments were performed to determine the effects of veratridine on Na and Ca currents in frog skeletal muscle fibres. 2. Veratridine (1 mu M) did not affect the kinetics of the fast Na current but it did induce a slowly inactivating tetrodotoxin-sensitive inward current that was apparent after Na current inactivation. This slow current had a peak amplitude of 6.7 +/- 0.7 mu A/cm(2) at -20 mV and decayed monoexponentially with a time constant of 606 +/- 77 ms. 3. The slow current had a voltage-dependence for activation that was similar to that of the fast Na current. Single depolarizing prepulses that induced complete inactivation of the fast Na channels, prevented development of the slow current. Trains of brief depolarizations at increasing frequencies increased the amplitude of the slow current. These results suggest that the slow current may be mediated by veratridine modified Na channels that must be in the open position. 4. The low concentration of veratridine (1 mu M) did not affect the Ca current, while 100 mu M veratridine reversibly suppressed the Ca current and shifted its peak current-voltage relation towards more negative potentials. Thus, veratridine appears not to be a selective fast Na channel modifier as it may also alter Ca channel gating properties in skeletal muscle fibres.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 25 : 8 (1994), p. 1661-1666. -
További szerzők:Varró András (1954-) (farmakológus, klinikai farmakológus) Lathrop, David A. Bryant, Shirley H.
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6.

001-es BibID:BIBFORM030344
035-os BibID:PMID:7721044 WOS:A1994QF05100019
Első szerző:Nánási Péter Pál (élettanász)
Cím:Effects of veratrine on ion currents in single rabbit cardiomyocytes / Péter P. Nanasi, András Varro, Shirley H. Bryant, David A. Lathrop
Dátum:1994
ISSN:0306-3623
Megjegyzések:1. Voltage-clamp experiments were performed to determine the effects of veratrine (1 mu g/ml) on Na and K currents in isolated rabbit ventricular cardiomyocytes. 2. Veratrine did not affect the inward rectifier K current, increased the inactivation time constant of the transient outward current (I-to) and induced a slowly decaying inward current component (I-v), which was sensitive to tetrodotoxin. 3. Inactivation of fast Na channels by application of short depolarizing prepulses to potentials between -90 and -50 mV prevented the development of I-v. I-v decayed biexponentially with time constants equal to 139 +/- 9.0 ms and 776 +/- 47 ms. The net amplitude of I-v and the time constants for its rapidly and slowly inactivating components were little affected by trains of conditioning prepulses to 0 mV. The contributions, however, of the fast and slow components to the net current were significantly altered by repetitive depolarizations. 4. These components of I-v are likely due to modification of open cardiac Na channels by veratrum alkaloids.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 25 : 8 (1994), p. 1667-1672. -
További szerzők:Varró András (1954-) (farmakológus, klinikai farmakológus) Bryant, Shirley H. Lathrop, David A.
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7.

001-es BibID:BIBFORM030498
035-os BibID:PMID: 2276592
Első szerző:Nánási Péter Pál (élettanász)
Cím:Use-dependent action of antiarrhythmic drugs in frog skeletal muscle and canine cardiac Purkinje fiber / Péter P. Nánási, András Varró, David A. Lathrop, Miklós Dankó
Dátum:1990
ISSN:0306-3623
Megjegyzések:1. Conventional microelectrode techniques were used to study the effect of quinidine (10 microM), lidocaine (20 microM), and verapamil (3-10 microM) on action potential upstroke (V+ max) in frog skeletal muscle and dog Purkinje fiber. 2. The frequency-dependent nature of V+ max depression induced by these drugs was similar in both preparations, however, quinidine was more potent in skeletal muscle while lidocaine was in Purkinje fibers. 3. In skeletal muscle tetrodotoxin (3 and 15 nM) and low concentrations of antiarrhythmic drugs proportionally reduced the maximum velocity of depolarization and repolarization (V+ max and V- max, respectively), whereas V- max was more depressed than V+ max by high concentrations (50-200 microM) of antiarrhythmics. Decreases in the overshoot potential were proportional to the V+ max block in the case of each drug. 4. These results indicate that therapeutically relevant concentrations of quinidine and lidocaine inhibit skeletal muscle Na+ channels in a use-dependent manner similar to heart, while at higher concentrations the K+ channels may also be blocked. Therapeutic implications of the results are discussed.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 21 : 5 (1990), p. 747-751. -
További szerzők:Varró András (1954-) (farmakológus, klinikai farmakológus) Lathrop, David A. Dankó Miklós
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8.

001-es BibID:BIBFORM030497
Első szerző:Nánási Péter Pál (élettanász)
Cím:Effect of antiarrhythmic drugs, TTX, and 4-aminopyridine on repetitive electrical activity in frog skeletal muscle / Péter P. Nánási, Miklós Dankó, David A. Lathrop
Dátum:1990
ISSN:0306-3623
Megjegyzések:1. Conventional microelectrode techniques were used to study the effects of antiarrhythmic drugs (quinidine, 2-20 microM; lidocaine, 5-50 microM; verapamil, 2-20 microM), 4-aminopyridine (4-AP, 50-100 microM), and tetrodotoxin (TTX, 1.5-6 nM) on repetitive electrical discharges induced in the muscle membrane in the presence of 1 microM cevadine. 2. Antiarrhythmic drugs and 4-AP produced progressive reduction of the maximum upstroke velocity (V+ max) of the discharges, while the cycle length was prolonged by each drug except 4-AP. 3. The efficacy in depression of V+ max and prolongation of cycle length was not proportional in the case of individual drugs. 4. A simple model of the repetitive activity incorporating drug-effects was presented. The cevadine-modified Na+ channels could be blocked by antiarrhythmic agents, however, the efficacy of these drugs on the normal and cevadine-modified Na+ channels were found to be different.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 21 : 4 (1990), p. 563-567. -
További szerzők:Dankó Miklós Lathrop, David A.
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9.

001-es BibID:BIBFORM030280
Első szerző:Nánási Péter Pál (élettanász)
Cím:Effects of methylene blue and ascorbate on transmembrane potential in frog skeletal muscle / Péter P. Nánási, Mátyás Dely
Dátum:1995
ISSN:0306-3623
Megjegyzések:1. The effects of methylene blue (MB, 10(-4) M) and ascorbate (ASC, 10(-4) M) on the resting membrane potential of frog skeletal muscle fibers were studied in Cl--free medium at various external K+ concentrations. 2. Muscle fibers formed two distinct populations according to their resting potentials (hyperpolarized to - 104 mV or depolarized to -31 mV) after a 90 min period of K+ withdrawal. ASC increased the relative contribution of hyperpolarized fibers, while in the presence of MB, all fibers depolarized during the 90 min of K+ withdrawal. 3. In the presence of 2.5 mM KC, ASC had no significant effect on the resting potential, while MB moved half of the fibers into the depolarized pool. Elevation of [K+](0) to 10 mM caused repolarization of all previously depolarized fibers (to -63 mV) in spite of the continuous presence of MB. 4. Ionic currents were measured during a 60 mV depolarization step using the double sucrose-gap technique. MB significantly increased the peak inward current, while ASC had no effect. The steady-state outward current was not affected by MB or ASC. 5. The results suggest that ionic conductances may be under redox control in frog skeletal muscle.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 26 : 6 (1995), p. 1307-1311. -
További szerzők:Dely Mátyás
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10.

001-es BibID:BIBFORM030275
Első szerző:Nánási Péter Pál (élettanász)
Cím:Action-potential duration and contractility in canine cardiac tissues : action of inotropic drugs / Péter P. Nánási, András Varró, David A. Lathrop
Dátum:1998
ISSN:0306-3623
Megjegyzések:1. Inotropic and electrophysiologic effects of veratrine, vesnarinone, d-sotalol and tetraethylammonium (TEA) were compared. Action potential duration (APD) and contractility were measured in isolated canine Purkinje fiber and ventricular trabecular muscle preparations by using standard microelectrode techniques. Each drug significantly increased APD and force development in either tissue. 2. Drug-induced increases in force development were normalized to increases in APD. The order of efficacy was found to be vesnarinone>veratrine>TEA in ventricular myocardium, whereas it was veratrine>>vesnarinone=d-sotalol=TEA in Purkinje fibers. 3. The force-APD relation was linear for all drugs in the concentrations used. 4. Simultaneous measurements of APD, force development and intracellular sodium ion activity (a(Na)(i)) in the presence of either veratrine or lidocaine indicated a linear relation between force development and changes in a(Na)(i). 5. The relation between APD and force development was different in ventricular and Purkinje fiber preparations. Differences in the veratrine sensitivity of the force-APD relation observed between Purkinje and ventricular preparations suggest that a(Na)(i)-dependent changes in Na+/Ca2+ exchange may play a more important role in regulation of force generation in Purkinje fibers than in ventricular myocardium. GEN PHARMAC 31;3:415-418, 1998. (C) 1998 Elsevier Science Inc.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 31 : 3 (1998), p. 415-418. -
További szerzők:Varró András (1954-) (farmakológus, klinikai farmakológus) Lathrop, David A.
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11.

001-es BibID:BIBFORM030271
Első szerző:Pacher Pál
Cím:Cardiac electrophysiological effects of citalopram in guinea pig papillary muscle comparison with clomipramine / Pál Pacher, Zsolt Bagi, Zoltán Lako-Futo, Zoltán Ungvari, Péter P. Nanasi, Valéria Kecskemeti
Dátum:2000
ISSN:0306-3623
Megjegyzések:The effect of citalopram, a selective serotonin reuptake inhibitor (SSRI) antidepressant, was studied on cardiac action potential configuration and compared with that of the tricyclic antidepressant (TCA) clomipramine. Conventional microelectrode techniques were used in right ventricular papillary muscle preparations of the guinea pig. Citalopram caused a concentration-dependent (10-100 mu M) shortening of action potential duration (APD), depression of plateau and overshoot potential, and reduction of maximum velocity of depolarization (V-max). No significant changes in resting membrane potential were observed. Similar results were obtained with clomipramine; however, reduction of V-max and overshoot was more pronounced with clomipramine, whereas citalopram caused relatively greater shortening of APD. Effects of both drugs were partly reversible. The results indicate that the SSRI antidepressant citalopram, similarly to TCA compounds, alters cardiac action potential configuration in guinea pig ventricular muscle, probably owing to inhibition of cardiac Na+ and Ca2+ channels. Differences in cardiac side effects of the two drugs may be related to their different actions on cardiac action potential configuration. (C) 2000 Elsevier Science inc. All rights reserved.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 34 : 1 (2000), p. 17-23. -
További szerzők:Bagi Zsolt (1974-) (orvos) Lakó-Futó Zoltán Ungvári Zoltán Nánási Péter Pál (1956-) (élettanász) Kecskeméti Valéria
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12.

001-es BibID:BIBFORM030279
Első szerző:Pankucsi Csaba (farmakológus)
Cím:Three distinct components of the negative inotropic action of lidocaine in dog Purkinje fiber / Csaba Pankucsi, András Varró, Péter P. Nánási
Dátum:1996
ISSN:0306-3623
Megjegyzések:1. The negative inotropic action of 10 mu M lidocaine and 100 mu M nicorandil was compared as a function of the pacing cycle length, ranging from 300-3000 ms, in isolated canine Purkinje fiber preparations. 2. The applied concentrations of lidocaine and nicorandil produced similar shortening of action potential duration; however, lidocaine compromised contractility stronger than nicorandil at each cycle length. 3. Normalizing the inotropic action of the drugs to their shortening effect on action potential duration, the negative inotropic action of lidocaine can be regarded as a sum of three distinct components: negative inotropy associated to the shortening of action potential duration per se, reduction of contractility likely due to direct inhibition of the fast sodium current and of the ''window'' sodium current by lidocaine.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 27 : 1 (1996), p. 69-71. -
További szerzők:Varró András (1954-) (farmakológus, klinikai farmakológus) Nánási Péter Pál (1956-) (élettanász)
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