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1.

001-es BibID:BIBFORM044406
035-os BibID:(dekdb)bibKLT00081800
Első szerző:Bányász Tamás (élettanász)
Cím:Exercise book : a physiology laboratory guide / Tamás Bányász, Julianna Cseri, László Csernoch, Miklós Dankó, István Jóna, László Kónya, Péter Nánási
Dátum:1994
Megjelenés:Debrecen : University Medical School of Debrecen, 1994
Terjedelem:105 p.
Tárgyszavak:Orvostudományok Elméleti orvostudományok feladatgyűjtemény
Élettan
További szerzők:Cseri Julianna (1949-2022) (laboratóriumi diagnosztika szakorvos) Csernoch László (1961-) (élettanász) Dankó Miklós Jóna István (1948-) (élettanász, fizikus) Kónya László Nánási Péter Pál (1956-) (élettanász)
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2.

001-es BibID:BIBFORM030499
035-os BibID:PMID:2279686 WOS:A1990EB78600008
Első szerző:Nánási Péter Pál (élettanász)
Cím:Different actions of aconitine and veratrum alkaloids on frog skeletal muscle / Péter P. Nanasi, Tamás Kiss, Miklós Danko, David A. Lathrop
Dátum:1990
ISSN:0306-3623
Megjegyzések:1. The electrophysiological effects of veratridine, cevadine and aconitine (10(-8)-2 x 10(-4), 2 x 10(-7)-2 x 10(-6) and 2 x 10(-6)-10(-4) mol/l, respectively) were compared on frog muscle membrane using conventional microelectrodes. 2. Veratridine and aconitine were equally effective in depolarizing the resting membrane with the threshold concentration of 5 x 10(-5) mol/l. 3. Volleys of repetitive discharges and slow transient depolarizations were observed when single electrical stimuli were applied in the presence of veratridine (5 x 10(-8)-2 x 10(-5) mol/l), but not aconitine. Volleys with aconitine could be evoked only by repetitive stimulation; however no tendency of repolarization was observed following these volleys. Two orders of magnitude more aconitine than veratridine was required to induce volleys with similar parameters. 4. The effects of cevadine were similar to those of the corresponding concentrations of veratridine. 5. The observed differences between the electrophysiological actions of aconitine and veratrum alkaloids may be explained in part with differences in Na+ channel inactivation produced by these toxins, in addition to differences in their use-dependent behavior.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 21 : 6 (1990), p. 863-868. -
További szerzők:Kiss Tamás Dankó Miklós Lathrop, David A.
Pályázati támogatás:2/666/88
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3.

001-es BibID:BIBFORM030356
035-os BibID:PMID:1668707 WOS:A1991JM65600007
Első szerző:Nánási Péter Pál (élettanász)
Cím:Slow membrane potential changes in skeletal muscle induced in Cl(-)-free medium / P. P. Nanasi, M. Danko
Dátum:1991
ISSN:0231-424X
Megjegyzések:1. Conventional microelectrode techniques were used to measure simultaneous changes in membrane potential (V(m)) and conductance (G(m)) induced by single electrical stimuli in muscles bathed in Cl--free solution containing 40 mM of tetraethylammonium (TEA+). 2. Stimulation induced slow transient depolarizations (slow response) accompanied by increased calcium conductance, while the potassium conductance was first elevated and later reduced. 3. Stepwise elevation of [K+]0 from 2.5 to 5 or 10 mM during the slow response evoked an abrupt repolarization of 42.3 +/- 8.9 mV (n = 4; p < 0.001), and 24.8 +/-3.5 +/- mV (n = 5; p < 0.001), respectively, while G(m) was increased to 1.45 +/- 0.25-fold (n = 5; p < 0.05). Neither the slow response nor K+-induced changes in V(m) or G(m) were sensitive to tetrodotoxin (3-mu-M), however, nifedipine (10-mu-M) abolished the slow response. 4. It was concluded that beyond the increase of calcium conductance, the ionic conductance of the inward rectifier K+ channel was reduced during the slow response, which could be restored by the elevation of [K+]0. The results suggest the possible contribution of these mechanisms to the electrical instability of myotonic muscles. Potential therapeutic consequences are discussed.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Physiologica Hungarica. - 78 : 4 (1991), p. 369-377. -
További szerzők:Dankó Miklós
Pályázati támogatás:1453
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4.

001-es BibID:BIBFORM030355
035-os BibID:WOS:A1992HG21400007 PMID:1372849
Első szerző:Nánási Péter Pál (élettanász)
Cím:Repetitive electrical activity of the muscle membrane induced in chloride-free medium / P. P. Nanasi, M. Danko
Dátum:1992
ISSN:0305-1870
Megjegyzések:1. Superficial fibres of frog skeletal muscle were electrically stimulated in Ringer solution where the chloride content had been replaced by various weakly permeant anions. Changes of the membrane potential were recorded at three different time scales. The complex response was initiated by a volley of fast repetitive action potentials (10-20 ms cycle length) superimposed on the ascending phase of a transient depolarization to - 35 mV. The transient depolarization was followed by a membrane potential oscillation (0.3-0.6 s cycle length). The parameters of the volley and membrane potential oscillation were not greatly affected by the substituent anion. 2. The transient depolarization was fully abolished by tetrodotoxin (3-mu-mol/L), but left unaffected by nifedipine (5-mu-mol/L), or by the replacement of extracellular Ca for Ni or Co. Tetraethylammonium (20-40 mmol/L) increased the duration and amplitude of the transient depolarization. The shape of transient depolarization was uniform in a given fibre, in spite of its marked variability under different experimental conditions. 3. Single outward current pulses applied in chloride-free solution containing tetraethylammonium (20-40 mmol/L) evoked prolonged depolarizations to positive membrane potentials accompanied by increases in the specific membrane conductance. This slow response, which was also frequently observed in the absence of TEA, was mediated by Ca ions, as it was insensitive to tetrodotoxin (3-mu-mol/L) but abolished by nifedipine (10-mu-mol/L). 4. Two populations of the muscle fibres were observed during the slow response. Some fibres repolarized completely, while others failed to produce complete repolarization but formed a plateau between - 20 and - 30 mV, lasting for several minutes. When the external K concentration was abruptly increased to 5 or 10 mmol/L during the plateau of the slow response, repolarization and increase in membrane conductance were observed. 5. In muscle fibres, having osmotically disrupted T-system, the duration of transient depolarization was in the range of minutes, in contrast to the range of seconds observed in intact fibres. The volley was preserved in glycerol treated fibres, however, the baseline of discharges was close to the resting potential and the rate of depolarization of the baseline was significantly less in glycerol treated than in intact fibres. 6. These results are consistent with the existence of a second stable membrane potential level in skeletal muscle between - 40 and - 30 mV. The depolarization and repolarization during the membrane potential oscillation and transient depolarization can be regarded as a partial or full transition, respectively, between these two stable membrane potential levels, possibly due to the conductance changes of the inward rectifier K channels. It seems likely that the various types of repetitive activity are also linked to these conductance changes indicating that they are endogenous properties of the skeletal muscle membrane.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Clinical and Experimental Pharmacology and Physiology. - 19 : 2 (1992), p. 127-136. -
További szerzők:Dankó Miklós
Pályázati támogatás:1453
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5.

001-es BibID:BIBFORM030354
035-os BibID:PMID:1330809 WOS:A1992HT47500003
Első szerző:Nánási Péter Pál (élettanász)
Cím:Nonlinear relationship between V+max and h infinity in frog skeletal muscle / P. P. Nanasi, M. Danko, A. Varro, D. A. Lathrop
Dátum:1992
ISSN:0231-5882
Megjegyzések:The relationship between the maximum velocity of action potential upstroke (V(max)+) and steady-state Na+ channel inactivation (h(infinity)) was studied in frog skeletal muscle during repetitive discharges evoked in the presence of cevadine (1-mu-mol/l). Conventional microelectrodes and vaseline-gap voltage-clamp techniques were used. A severe degree of nonlinearity was found between (h(infinity)) and (V(max)+) especially when the Na+ conductance (gNa) was small. The observed nonlinearity could be explained as a property of the normal Na+ channel gating in skeletal muscle rather than that of cevadine-modified channels. Part of this work has been published in abstract form in Biophys. J. 57: 105A, 1990.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Physiology and Biophysics. - 11 : 2 (1992), p. 159-167. -
További szerzők:Dankó Miklós Varró András (1954-) (farmakológus, klinikai farmakológus) Lathrop, David A.
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6.

001-es BibID:BIBFORM030498
035-os BibID:PMID: 2276592
Első szerző:Nánási Péter Pál (élettanász)
Cím:Use-dependent action of antiarrhythmic drugs in frog skeletal muscle and canine cardiac Purkinje fiber / Péter P. Nánási, András Varró, David A. Lathrop, Miklós Dankó
Dátum:1990
ISSN:0306-3623
Megjegyzések:1. Conventional microelectrode techniques were used to study the effect of quinidine (10 microM), lidocaine (20 microM), and verapamil (3-10 microM) on action potential upstroke (V+ max) in frog skeletal muscle and dog Purkinje fiber. 2. The frequency-dependent nature of V+ max depression induced by these drugs was similar in both preparations, however, quinidine was more potent in skeletal muscle while lidocaine was in Purkinje fibers. 3. In skeletal muscle tetrodotoxin (3 and 15 nM) and low concentrations of antiarrhythmic drugs proportionally reduced the maximum velocity of depolarization and repolarization (V+ max and V- max, respectively), whereas V- max was more depressed than V+ max by high concentrations (50-200 microM) of antiarrhythmics. Decreases in the overshoot potential were proportional to the V+ max block in the case of each drug. 4. These results indicate that therapeutically relevant concentrations of quinidine and lidocaine inhibit skeletal muscle Na+ channels in a use-dependent manner similar to heart, while at higher concentrations the K+ channels may also be blocked. Therapeutic implications of the results are discussed.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 21 : 5 (1990), p. 747-751. -
További szerzők:Varró András (1954-) (farmakológus, klinikai farmakológus) Lathrop, David A. Dankó Miklós
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7.

001-es BibID:BIBFORM030497
Első szerző:Nánási Péter Pál (élettanász)
Cím:Effect of antiarrhythmic drugs, TTX, and 4-aminopyridine on repetitive electrical activity in frog skeletal muscle / Péter P. Nánási, Miklós Dankó, David A. Lathrop
Dátum:1990
ISSN:0306-3623
Megjegyzések:1. Conventional microelectrode techniques were used to study the effects of antiarrhythmic drugs (quinidine, 2-20 microM; lidocaine, 5-50 microM; verapamil, 2-20 microM), 4-aminopyridine (4-AP, 50-100 microM), and tetrodotoxin (TTX, 1.5-6 nM) on repetitive electrical discharges induced in the muscle membrane in the presence of 1 microM cevadine. 2. Antiarrhythmic drugs and 4-AP produced progressive reduction of the maximum upstroke velocity (V+ max) of the discharges, while the cycle length was prolonged by each drug except 4-AP. 3. The efficacy in depression of V+ max and prolongation of cycle length was not proportional in the case of individual drugs. 4. A simple model of the repetitive activity incorporating drug-effects was presented. The cevadine-modified Na+ channels could be blocked by antiarrhythmic agents, however, the efficacy of these drugs on the normal and cevadine-modified Na+ channels were found to be different.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Pharmacology. - 21 : 4 (1990), p. 563-567. -
További szerzők:Dankó Miklós Lathrop, David A.
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8.

001-es BibID:BIBFORM030496
Első szerző:Nánási Péter Pál (élettanász)
Cím:Effects of bencyclane on normal and cevadine-modified Na channels in frog skeletal muscle / P. P. Nanasi, Z. Bodnar, M. Danko
Dátum:1989
ISSN:0231-5882
Megjegyzések:The effect of 10(-5) mol/l bencyclane on the repetitive electrical activity of muscle membrane was studied with the conventional microelectrode technique. Electrical activity was induced by repetitive stimulation in normal Ringer solution (train) or by a single depolarizing current pulse in the presence of 10(-6) mol/l cevadine (volley). Bencyclane decreased, in a use-dependent manner, the maximum rates of depolarization and repolarization (Vmax+ and Vmax-, resp.) of the action potentials both of the train and the volley. The inhibition of Vmax+ and Vmax- was proportional; however, it was stronger for the volleys than for the trains. The cycle length (mean interspike interval) of the volley was increased by bencyclane; the prolongation was progressive during consecutive cycles. The dissociation of bencyclane from the Na channel was studied by applying trains of different durations with equal pulse numbers. Bencyclane at a higher concentration (5 x 10(-5) mol/l) caused a reversible tonic block: the overshoot potentials, Vmax+ and Vmax- were markedly reduced. The reduction of Vmax- was slightly stronger than that of Vmax+. Slow membrane potential oscillation (SMPO) was evoked by treating the muscle with 10(-4) mol/l of cevadine. The administration of 5 x 10(-6) mol/l bencyclane decreased the frequency of SMPO, while 10(-5) mol/l bencyclane terminated the slow oscillation activity without changing its baseline potential. The present results indicate that bencyclane induces use-dependent inhibition of Na channels in muscle, similarly as do class 1 antiarrhytnmic drugs. Inhibition was observed with both normal and cevadine-modified Na channels.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:General Physiology and Biophysics. - 8 : 5 (1989), p. 447-458. -
További szerzők:Bodnár Zoltán Dankó Miklós
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9.

001-es BibID:BIBFORM030495
035-os BibID:WOS:A1989AB05200009
Első szerző:Nánási Péter Pál (élettanász)
Cím:Paradox response of frog muscle membrane to changes in external potassium / P. P. Nánási, M. Dankó
Dátum:1989
ISSN:0031-6768
Megjegyzések:Applying conventional microelectrode technique the anomalous behaviour of membrane potential in response to changes in [K+]o was demonstrated in normal and cevadine-treated muscles bathed in Cl- -free medium. Partial repolarization of the cevadine-depolarized membrane and reappearance of the slow membrane potential oscillation (SMPO) were induced by elevating [K+]o from 2.5 mM to 10-20 mM. Both effects were reversed by return to 2.5 mM [K+]o. The K-induced repolarization was markedly reduced by 20 mM Cs+, but not by 0.1 mM ouabain, 1 mM 4-aminopyridine, or 1 mM diethyl-pyrocarbonate. The elevation of [K+]o failed to repolarize muscle fibers that had been depolarized only to a small extent. No K-induced repolarization has been observed in Cl- -containing fluid. In cevadine-free experiments the omission of potassium from the extracellular space in Cl- -free solution hyperpolarized some of the fibers, while depolarized others. Strong electrical stimuli applied in zero K-zero Cl solution turned all the fibers into depolarized state; on returning to 2.5 mM [K+]o complete repolarization was achieved in most of the fibers. It has been concluded that the paradox response of the muscle membrane to changes in [K+]o can be attributed to the K-dependent conductance changes of the inward rectifier K channel providing an explanation for the plateau-formation of SMPO and for the existence of two stable levels of membrane potential of the skeletal muscle bathed in Cl- -free medium.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Pflügers Archiv. - 414 : 2 (1989), p. 157-161. -
További szerzők:Dankó Miklós
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10.

001-es BibID:BIBFORM030494
Első szerző:Nánási Péter Pál (élettanász)
Cím:Use-dependent blockade of sodium channels induced by bencyclane in frog skeletal muscle and canine cardiac Purkinje fiber / P. P. Nanasi, A. Varró, G. Rablóczky, M. Dankó
Dátum:1987
ISSN:0003-9780
Megjegyzések:Applying conventional microelectrode technique, the effect of bencyclane was studied on the maximal rate of rise (Vmax) of the transmembrane action potential in frog skeletal muscle and canine cardiac Purkinje fiber. Bencyclane (10 microM) decreased the Vmax from 333.7 +/- 6.9 V/sec to 302.7 +/- 10.2 V/sec (n = 6, p less than 0.05) in skeletal muscle without changing the resting membrane potential. If repetitive stimulation with different constant cycle lengths was applied, a further, frequency-dependent decrease of Vmax developed in both tissues with similar frequency-dependence. In skeletal muscle bencyclane increased the time of 50% repolarization by 33.3 +/- 2.5% (n = 7, p less than 0.01) and decreased the overshoot potential by 11.3 +/- 0.72 mV (n = 7, p less than 0.01) measured at 250 msec cycle length. In cardiac Purkinje fiber bencyclane shortened the action potential duration (APD90) from 258.3 +/- 15.4 msec to 241.7 +/- 12.1 msec (n = 6, p less than 0.05) without changing the resting membrane potential and action potential amplitude measured at 500 msec cycle length. The comparable size of the Vmax-block at the same cycle lengths observed in skeletal muscle (short APD) and Purkinje fiber (long APD) suggests that the inhibition may by mainly attributed to the open sodium channel population. It was concluded that the antiarrhythmic action of bencyclane, based on the use-dependent blockade of sodium channels, might be an important component of the therapeutic effect of bencyclane.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Archives Internationales De Pharmacodynamie Et De Therapie. - 290 : 2 (1987), p. 278-287. -
További szerzők:Varró András (1954-) (farmakológus, klinikai farmakológus) Rablóczky György Dankó Miklós
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11.

001-es BibID:BIBFORM044403
035-os BibID:(dekdb)bibDOT00005491
Cím:Physiological practice : a laboratory guide / Tamás Bányász, Júlia Cseri, Miklós Dankó, István Kalapos, Péter Nánási, Géza Szűcs
Dátum:1988
Megjelenés:Debrecen : Debreceni Orvostudományi Egyetem, 1988
Terjedelem:229 p.
Tárgyszavak:Orvostudományok Elméleti orvostudományok jegyzet
Élettan
További szerzők:Bányász Tamás (1960-) (élettanász) Cseri Julianna (1949-2022) (laboratóriumi diagnosztika szakorvos) Dankó Miklós Kalapos István (1954-) (orvos, élettanász) Nánási Péter Pál (1956-) (élettanász) Szűcs Géza (1948-) (élettanász)
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