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001-es BibID:	BIBFORM001509
Első szerző:	Zsuga Judit (neurológus, pszichoterapeuta, egészségügyi szakmanager)
Cím:	Serum asymmetric dimethylarginine negatively correlates with intima-media thickness in early-onset atherosclerosis / Judit Zsuga, Janos Török, Mária Tünde Magyar, Attila Valikovics, Rudolf Gesztelyi, Sándor Kéki, Laszló Csiba, Miklos Zsuga, Dániel Bereczki
Dátum:	2007
Megjegyzések:	Asymmetric dimethylarginine (ADMA) assumes a significant role in atherosclerosis by inhibiting the endothelial nitric oxide synthase (eNOS). Moreover, ADMA inhibits the inducible NOS (iNOS), the isoform that triggers atherosclerosis via peroxynitrite formation. Therefore, we investigated whether ADMA is a risk or protective factor in the atherosclerotic process. Intima-media thickness (IMT) of the common carotid artery, a surrogate for vascular diseases,was chosen as the outcome variable of interest. Methods: Sixty patients younger than 55 years having at least 30% stenosis of the internal carotid artery and 30 age- and gendermatched controls were recruited at a community-based neurosonological laboratory. We investigated relatively young patients to circumvent the confounding effect age has in the development of atherosclerosis. Results: The IMT showed a negative correlation with ADMA upon analysis of the pooled data (Spearman correlation coefficient -0.300, p = 0.0041) and the atherosclerotic stratum (Spearman correlation coefficient -0.323, p = 0.012). A multiple linear regression model containing all determinant factors of IMT previously identified by simple regression was used to further quantify the relationship between IMT and ADMA. Thenegative association between IMT and ADMA remained statistically significant ( beta: -0.510, CI: -0.894, -0.127; p = 0.010), furthermore it was even stronger in the atherosclerotic stratum( beta : -0.67, CI: -1.16, -0.18; p = 0.008). Conclusions: A minimal increase in ADMA concentration may be protective by inhibiting iNOS but not eNOS in states where iNOS is induced, e.g. inflammation accompanying atherosclerosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban atherosclerosis inflammation carotid arteries vascular risk factors nitric oxide synthase
Megjelenés:	Cerebrovascular Diseases 23 : 5-6 (2007), p. 388-394. -
További szerzők:	Török János Magyar Mária Tünde (1970-) (neurológus) Valikovics Attila Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Kéki Sándor (1964-) (polimer kémikus) Csiba László (1952-) (neurológus, pszichiáter) Zsuga Miklós (1944-) (polimer kémikus) Bereczki Dániel (1960-) (neurológus)
Internet cím:	DOI elektronikus változat
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