Találati lista | Tudóstér

001-es BibID:	BIBFORM038629
035-os BibID:	PMID:9272279
Első szerző:	Csípő István (vegyész)
Cím:	Serum complement activation of SLE patients during plasmapheresis / Csipő I., Kávai M., Kiss E., Bedő Z., Csongor J., Szegedi Gy., Philbert F., Cohen J. H.
Dátum:	1997
ISSN:	0891-6934
Megjegyzések:	The erythrocyte complement receptor 1 (ECR1)-immune complex binding assay is a sensitive method for the determination of complement fragments which can be activated by bovine serum albumin (BSA)-anti-BSA in vitro. When the C3b/C4b containing bovine serum albumin (BSA)-anti-BSA was formed in the presence of the serum of patients with systemic lupus erythematosus (SLE) its binding to ECR1 was found to be lower than that formed in sera of normal volunteers. The plasmapheresis of SLE patients homozygous for the CR1/E high density allele displays a beneficial effect on the formation of C3b/C4b containing BSA-anti-BSA and its binding to ECR1. There was no significant correlation between the serum C3/C4 level and the percentage of C3b/C4b containing BSA-anti-BSA binding to the ECR1 of SLE patients during plasmapheresis. At the same time, there was an inverse correlation between the serum immune complex level and the ECR1 binding, which was significant in 3 of 5 cases. These data suggest that, besides the determination of different components of complement activation, the functional assay of complement activation might be useful in monitoring the effect of plasmapheresis in SLE.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény 0 (Antibodies) 0 (Antigen-Antibody Complex) 0 (Receptors, Complement 3b) 0 (Serum Albumin, Bovine) 80295-43-8 (Complement C3b) 80295-50-7 (Complement C4b) Adult Animals Antibodies/immunology Antigen-Antibody Complex/blood Cattle Complement Activation/immunology Complement C3b/immunology Complement C4b/immunology Erythrocytes/immunology Female Humans Lupus Erythematosus, Systemic/blood/immunology Male Middle Aged Plasmapheresis Receptors, Complement 3b/immunology Serum Albumin, Bovine/immunology
Megjelenés:	Autoimmunity. - 25 : 3 (1997), p. 139-146. -
További szerzők:	Kávai Mária (1930-) (vegyész) Kiss Emese (1960-) (belgyógyász, immunológus) Bedő Zoltán Csongor József Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Philbert, F. Cohen, J. H. M.
Borító:
Saját polcon:

001-es BibID:	BIBFORM033501
035-os BibID:	PMID:17453714 WOS:000246340100001
Első szerző:	Csípő István (vegyész)
Cím:	Determination of ligand binding capacity of soluble Fc gamma RII and Fc gamma RIII in sera of patients with SLE / Istvan Csipo, Sandor Barath, Emese Kiss, Gabriella Szucs, Gyula Szegedi, Maria Kavai
Dátum:	2007
ISSN:	0891-6934
Megjegyzések:	BACKGROUND: Soluble, human low affinity Fcgamma receptors, such as sFcgammaRII and sFcgammaRIII, are known to play a pathologic role in different diseases. Sandwich ELISAs had previously been applied for the specific detection and determination of these soluble receptors. In these ELISAs, commercial monoclonal antibodies (Ab) were used as capture antibodies with monoclonal or polyclonal antibodies serving as detector Abs. Increased levels of cell-free FcgammaRIII have been detected in patients with lupus but the functions and levels of sFcgammaRII have not been fully characterized yet. OBJECTIVES: The aim of this work was to determine the ligand binding capacities and levels of soluble FcgammaRII and FcgammaRIII in sera of patients with systemic lupus erythematosus (SLE). Moreover, correlation between the levels of sFcgammaRII and sFcgammaRIII and the clinical activity of the disease were investigated. METHODS: Sera of 47 patients with SLE, and 51 healthy subjects were analyzed. In the newly developed indirect sandwich ELISAs commercial monoclonal anti-FcgammaRs are used as capture antibodies, and the ligand of FcgammaRII and FcgammaRIII, an artificial immune complex (IC), serves as a detection component replacing the second antibodies used in previous methods. RESULTS: The ligand binding capacity of both soluble FcgammaRII and sFcgammaRIII were elevated in the sera of SLE patients compared to control samples. This increase was significant in patients with the active disease (n = 30; p < 0.01). It was also revealed that a substantial part of the soluble Fcgamma receptors in these patients was bound in vivo to circulating IC. CONCLUSION: These newly developed ELISAs are probably more phisiologically relevant than other previous assays because they detect the circulating receptors on the basis their in vitro ligan binding capacities. Therefore this method can separately measure the levels of the soluble, free FcgammaRs and those bound circulating IC in vivo.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Autoimmunity 40 : 3 (2007), p. 165-168. -
További szerzők:	Baráth Sándor (1977-) (biológus) Kiss Emese (1960-) (belgyógyász, immunológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Kávai Mária (1930-) (vegyész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM013920
Első szerző:	Hajas Ágota Helga (orvos)
Cím:	Vitamin D insufficiency in a large MCTD population / Hajas Ágota, Sándor János, Csáthy László, Csipő István, Baráth Sándor, Paragh György, Seres Ildikó, Szegedi Gyula, Shoenfeld Yehuda, Bodolay Edit
Dátum:	2011
ISSN:	1568-9972
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Autoimmunity Reviews. - 10 : 6 (2011), p. 317-324. -
További szerzők:	Sándor János (1966-) (orvos-epidemiológus) Csáthy László (1979-) (laboratóriumi szakorvos) Csípő István (1953-) (vegyész) Baráth Sándor (1977-) (biológus) Paragh György (1953-) (belgyógyász) Seres Ildikó (1954-) (biokémikus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Shoenfeld, Yehuda Bodolay Edit (1950-) (belgyógyász, allergológus és klinikai immunológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI elektronikus változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM038628
035-os BibID:	PMID:9161700
Első szerző:	Kiss Emese (belgyógyász, immunológus)
Cím:	CR1 density polymorphism and expression on erythrocytes of patients with systemic lupus erythematosus / Kiss E., Csipő I., Cohen J. H., Reveil B., Kávai M., Szegedi Gy.
Dátum:	1996
ISSN:	0891-6934
Megjegyzések:	The present study investigated the expressed number of CR1 on erythrocytes (E) in relationship of the CR1 density genotype from 46 patients with systemic lupus erythematosus (SLE) and 47 healthy volunteers. The CR1 genotype was determined by a method based on polymerase chain reaction (PCR) amplification of the genomic DNA fragment of 1.8 kb separated by HindIII endonuclease digestion and agarose gel electrophoresis. Our data supported the earlier results that the number of binding sites/E for monoclonal anti-CR1 decreased among SLE patients compared with normal individuals having the same alleles for the CR1/E density. At the same time the novelty of our recent results was that the decreased expression of CR1 on E correlated significantly with kidney involvement in patients homozygous for the CR1/E high density allele (HH). These data suggest that the deficiency of the detectable number of CR1 on erythrocytes is acquired in this SLE population.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény 0 (Receptors, Complement) 0 (Receptors, Complement 3b) Erythrocytes/chemistry/immunology Female Genotype Heterozygote Homozygote Humans Lupus Erythematosus, Systemic/genetics/metabolism/pathology Male Polymorphism, Genetic/genetics Polymorphism, Restriction Fragment Length Receptors, Complement/genetics Receptors, Complement 3b/biosynthesis/genetics/immunology Severity of Illness Index
Megjelenés:	Autoimmunity. - 25 : 1 (1996), p. 53-58. -
További szerzők:	Cohen, J. H. M. Reveil, B. Kávai Mária (1930-) (vegyész) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Csípő István (1953-) (vegyész)
Borító:
Saját polcon: