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001-es BibID:	BIBFORM038689
035-os BibID:	PMID:15301236
Első szerző:	Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:	Anti-endothelial cell antibodies in mixed connective tissue disease : frequency and association with clinical symptoms / E. Bodolay, I. Csipő, I. Gál, S. Sipka, E. Gyimesi, Z. Szekanecz, G. Szegedi
Dátum:	2004
Megjegyzések:	AbstractOBJECTIVE: Anti-endothelial cell antibodies (AECA) have been described in a number of systemic autoimmune-inflammatory diseases. However, little is known about the relationship of AECA with mixed connective tissue disease (MCTD).METHODS: Using an ELISA, the presence of AECA was evaluated in the sera of 33 patients with MCTD and of 30 healthy subjects as controls. Serum levels of AECA were correlated with clinical activity, as well as the existence of various organ manifestations.RESULTS: Significantly increased AECA production was observed in MCTD patients (OD = 0.337+/-0.193) compared to controls (OD = 0.136+/-0.065). In addition, patients with active MCTD exerted significantly elevated serum AECA levels (OD = 0.487+/-0.090) than did patients with inactive MCTD (OD = 0.135+/-0.040) or controls. MCTD patients with pulmonary hypertension had a tendency of increased serum AECA levels (OD = 0.452+/-0.080) compared to patients without this manifestation (OD = 0.307+/-0.039). Sera of MCTD patients with AECA concentrations higher or lower than the mean serum AECA level in controls+2SD (OD = 0.266) were considered as AECAhigh (n = 19/33) and AECAlow (n = 14/33), respectively. Interestingly, all patients with active disease had AECAhigh, while all inactive MCTD patients had AECAlow sera. IgG purified from ten MCTD sera (OD = 0.415+/-0.290) showed a tendency to up-regulate E-selectin expression on cultured human umbilical vein endothelial cells (HUVEC) compared to IgG from control sera. In addition, AECAhigh MCTD sera exerted significantly increased stimulatory effect on endothelial E-selectin expression (OD = 0.651+/-0.190) compared to AECAlow (OD = 0.178+/-0.110) or control sera (OD = 0. 131+/-0.080).CONCLUSION: AECA may activate endothelial cells by the up-regulation of E-selectin expression and thus may be implicated in the pathogenesis of MCTD. Furthermore, serum AECA may be a useful marker of endothelial activation and clinical activity in this disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban anti-endothelial antibodies mixed connective tissue disease symptoms Adult Autoantibodies Cells, Cultured Dose-Response Relationship, Immunologic E-Selectin Endothelial Cells Endothelium, Vascular Enzyme-Linked Immunosorbent Assay Female Humans Hypertension, Pulmonary Immunoglobulin G Male Middle Aged Mixed Connective Tissue Disease egyetemen (Magyarországon) készült közlemény
Megjelenés:	Clinican and Experimental Rheumatology. - 22 : 4 (2004), p. 409-415. -
További szerzők:	Csípő István (1953-) (vegyész) Gál I. Sipka Sándor (1945-) (laboratóriumi szakorvos) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM038622
035-os BibID:	PMID:7842534
Első szerző:	Czirják László
Cím:	Anti-platelet antibodies against gpIIb/IIIa in systemic sclerosis / Czirják L., Molnár I., Csipő I., Szabolcs M., Mihály A., Szegedi Gy.
Dátum:	1994
ISSN:	0392-856X
Megjegyzések:	An enzyme-linked immunosorbent assay and western immunoblotting analysis were used to detect anti-platelet antibodies in the sera of 50 patients with systemic sclerosis. Eleven (22%) positive sera were found by ELISA. Serial investigations showed that the presence of these antibodies was often transient. Immunoblotting analysis demonstrated that the antibodies were directed against a 114 kDa antigen. Using monoclonal antibody, anti-platelet antibodies directed against gpIIIa were found in 4 cases. Similar to immune thrombocytopenia and lupus erythematosus, a significant portion of the anti-platelet antibodies were also directed against the glycoprotein complex IIb/IIIa in systemic sclerosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény 0 (Autoantibodies) 0 (Platelet Membrane Glycoproteins) Adult Autoantibodies/immunology Blood Platelets/immunology Blotting, Western Enzyme-Linked Immunosorbent Assay Humans Middle Aged Platelet Membrane Glycoproteins/immunology Scleroderma, Systemic/immunology
Megjelenés:	Clinical and Experimental Rheumatology. - 12 : 5 (1994), p. 527-529. -
További szerzők:	Molnár I. Marien, Szabolcs Mihály A. Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Csípő István (1953-) (vegyész)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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