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001-es BibID:BIBFORM004806
Első szerző:Harangi Mariann (belgyógyász, endokrinológus)
Cím:Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease / Mariann Harangi, Ildiko Seres, Maria T. Magyar, Istvan Csipo, Sandor Sipka, Attila Valikovics, Laszlo Csiba, Daniel Bereczki, Gyorgy Paragh
Dátum:2008
Megjegyzések:Human serum paraoxonase (PON1) protects lipoproteins against oxidation by hydrolyzing lipid peroxides in oxidized low-density lipoprotein (oxLDL); therefore, it may protect against atherosclerosis. PON1 activity and polymorphisms have been inconsistently associated with carotid artery disease. The goal of this study was to clarify the role of PON1 activity and phenotype on carotid artery disease and its correlation with some inflammatory and immune markers in subjects under 55 years with early-onset carotid atherosclerosis. Methods: Sixty patients with occlusive carotid artery disease and 30 healthy controls were enrolled. Intimamedia thickness (IMT) was measured by high-resolution ultrasound of both common carotid arteries. Anti-oxLDL antibody levels were determined by ELISA. Results: In the whole study population we found a negative correlation between PON1 activity and IMT (r = -0.27, p = 0.011), and between saltstimulated PON1 activity and IMT (r = -0.24, p = 0.02). Both PON1 activity and salt-stimulated PON1 activity negatively correlated with anti-oxLDL levels (r = -0.28, p = 0.008; r = -0.26, p = 0.01). PON1 activity was lower in patients compared to controls; however, the difference was not significant.PON1 phenotype distribution of patients and controls did not differ significantly. Conclusion: The importance of PON1 activity as a redictive risk factor for early-onset occlusive carotid artery disease should be assessed in future studies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Paraoxonase
Intima-media thickness
egyetemen (Magyarországon) készült közlemény
Megjelenés:Cerebrovascular Diseases 25 : 1-2 (2008), p. 122-128. -
További szerzők:Seres Ildikó (1954-) (biokémikus) Magyar Mária Tünde (1970-) (neurológus) Csípő István (1953-) (vegyész) Sipka Sándor (1945-) (laboratóriumi szakorvos) Valikovics Attila Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus) Paragh György (1953-) (belgyógyász)
Internet cím:DOI
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2.

001-es BibID:BIBFORM002294
Első szerző:Magyar Mária Tünde (neurológus)
Cím:Elevated white blood cell count, CRP and fibrinogen levels are not associated with increased anti-endothelial and anti-ox-LDL antibody, MCP-1, and RANTES levels in early onset occlusive carotid artery disease / Magyar Mária Tünde, Bereczki Dániel, Csípő István, Gyimesi Edit, Csiba László, Valikovics Attila, Balla József, Sipka Sándor
Dátum:2007
Megjegyzések:Inflammatory processes have importance in atherosclerosis. We evaluated if subjects below 55 years of age with occlusive carotid artery disease have higher serum levels of antibodies against oxidized LDL and endothelial cells and the chemokines MCP-1 and RANTES than age matched subjects without atherosclerosis. Methods and results. Sixty patients with occlusive carotid artery disease (stenosis or occlusion) and 30 age-matched controls participated in the study. We measured the degree of carotid artery stenosis and intima-media thickness (IMT) by duplex ultrasound. White blood cell count (WBC), C-reactive protein (CRP), and fibrinogen levels were significantly higher in patients (means ± SD: 7.5 ± 1.8 vs. 6.1 ± 1.1 G/L, p < 0.001; 7.7 ± 20.7 vs. 2.5 ± 1.9 mg/L, p = 0.015; and 3.7 ± 0.9 vs. 3.1 ± 0.5 g/L, p < 0.001, respectively). Antibody levels against oxidized LDL and endothelial cells (21.1 ± 22.9 and 19.9 ± 15.3 EU/mL, p = 0.6; and 19 ± 15 vs. 20 ± 9 U/mL, p = 0.07) and RANTES and MCP-1 levels (72.4 ± 32.3 vs. 73.8 ± 27.3 ng/mL, p = 0.7; and 468 ± 1041 vs. 318 ± 131 pg/mL, p = 0.7) did not differ significantly between patients and controls and did not correlate with IMT. Conclusions. Higher levels of WBC, CRP, and fibrinogen suggest an ongoing inflammation in early-onset carotid atherosclerosis, but increased IMT is not associated by the elevation of serum levels of chemokines and antibodies evaluated in this study.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
atherosclerosis
inflammation
cytokines
Rantes
MCP-1
Megjelenés:Cytokine 37 : 1 (2007), p. 44-50. -
További szerzők:Bereczki Dániel (1960-) (neurológus) Csípő István (1953-) (vegyész) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Csiba László (1952-) (neurológus, pszichiáter) Valikovics Attila Balla József (1959-) (belgyógyász, nephrológus) Sipka Sándor (1945-) (laboratóriumi szakorvos)
Internet cím:elektronikus változat
DOI
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