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001-es BibID:	BIBFORM068546
Első szerző:	Veres Péter (vegyész)
Cím:	Mechanism of drug release from silica-gelatin aerogel-relationship between matrix structure and release kinetics / Péter Veres, Mónika Kéri, István Bányai, István Lázár, István Fábián, Concepción Domingo, József Kalmár
Dátum:	2017
ISSN:	0927-7765
Megjegyzések:	Specific features of a silica-gelatin aerogel (3 wt.% gelatin content) in relation to drug delivery has beenstudied. It was confirmed that the release of both ibuprofen (IBU) and ketoprofen (KET) is about tenfold faster from loaded silica-gelatin aerogel than from pure silica aerogel, although the two matrices arestructurally very similar. The main goal of the study was to understand the mechanistic background of thestriking difference between the delivery properties of these closely related porous materials. Hydratedand dispersed silica-gelatin aerogel has been characterized by NMR cryoporometry, diffusiometry andrelaxometry. The pore structure of the silica aerogel remains intact when it disintegrates in water. In contrast, dispersed silica-gelatin aerogel develops a strong hydration sphere, which reshapes the pore wallsand deforms the pore structure. The drug release kinetics was studied on a few minutes time scale with1 s time resolution. Simultaneous evaluation of all relevant kinetic and structural information confirmedthat strong hydration of the silica-gelatin skeleton facilitates the rapid desorption and dissolution of thedrugs from the loaded aerogel. Such a driving force is not operative in pure silica aerogels.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Aerogel structure Drug release Kinetics NMR spectroscopy
Megjelenés:	Colloids and Surfaces B-Biointerfaces. - 152 (2017), p. 229-237. -
További szerzők:	Kéri Mónika (1984-) (környezetkutató vegyész) Bányai István (1953-) (vegyész) Lázár István (1959-) (vegyész) Fábián István (1956-) (vegyész) Domingo, Concepción Kalmár József (1985-) (vegyész)
Pályázati támogatás:	OTKA-105156 OTKA RH/751/2015 Egyéb TÁMOP-4.2.4A/2-11/1-2012-0001 TÁMOP TÁMOP-4.2.4B/2-11/1-2012-0001 TÁMOP GINOP-2.3.2-15-2016-00008 GINOP
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001-es BibID:	BIBFORM067363
035-os BibID:	(scopus)84949604750 (wos)000367384700019
Első szerző:	Veres Péter (vegyész)
Cím:	Hybrid aerogel preparations as drug delivery matrices for low water-solubility drugs / Peter Veres, Ana M. López-Periago, István Lázár, Javier Saurina, Concepción Domingo
Dátum:	2015
ISSN:	0378-5173
Megjegyzések:	A comprehensive study of 14 hybrid aerogels of different composition with applications in drug delivery has been carried out. The overall objective was to modulate the release behavior of drug-impregnated aerogels, from an almost instantaneous release to a semi-retarded delivery prolonged during several hours, through internal surface functionalization. The designed hybrid aerogels were composed of silica and gelatin and functionalized with either phenyl, long (16) hydrocarbon chain or methyl moiety. As model systems, three class II active agents (pKa < 5.5), ibuprofen, ketoprofen and triflusal, were chosen to impregnate the aerogels. The work relied on the use of supercritical fluid technology for both the synthesis and functionalization of the hybrid aerogels, as well as for the impregnation with an active agent using supercritical CO2 as a solvent. For the impregnated aerogels, in vitro release profiles were recorded under gastric and intestinal pH-conditions using HPLC techniques. The release behavior observed for the three studied drugs was explained considering the measured dissolution profiles of the crystalline drugs, the aerogel composition and its functionalization. Such features are considered of great interest to tailor the bioavailability of drugs with low water solubility.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Supercritical CO2 Hybrid aerogel Silica Gelatin Acid drugs
Megjelenés:	International Journal of Pharmaceutics. - 496 : 2 (2015), p. 360-370. -
További szerzők:	López-Periago, Ana M. Lázár István (1959-) (vegyész) Saurina, Javier Domingo, Concepción
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0036 TÁMOP TÁMOP-4.2.4B/2-11/1-2012-0001 TÁMOP
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