CCL

Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM004631
Első szerző:Gáspár Rezső (biofizikus)
Cím:Evidence of non-synaptic regulation of postpartum uterine contractility in the rat / Gaspar, R., Marki, A., Zupko, I., Falkay, G.
Dátum:1998
ISSN:024-3205
Megjegyzések:Myometrial tissue rings from postpartum rats (24 h after delivery) were studied in vitro by electric field stimulation, and the alpha1/beta2-adrenoceptor ratio was determined by a radioligand binding technique. Pregnancy-denervated uterine rings were stimulated by long-duration pulses (100 ms). The contractions were inhibited by beta2-agonists (terbutaline and fenoterol) and alpha-antagonists (phentolamine, urapidil and yohimbine) in a concentration-dependent manner. Their effects were not altered by the adrenergic neuron-blocking agent bretylium. The alpha-antagonists (except phentolamine) elicited the same maximal inhibition as the beta2-agonists. Receptor assays revealed that the alpha1/beta2 ratio was about 2 in the measured uteri. It was concluded that the inhibitory effects of alpha-antagonists and beta2-agonists are mediated via non-synaptic adrenoceptors of the denervated postpartum rat uterus. The same inhibitory activity could be explained by the greater amount of alpha-receptors. It is believed that this is the first functional proof of the existence of non-synaptic alpha1-adrenoceptors in smooth muscle.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adrenergic beta-Agonists
Animal
Binding Sites
Electric Stimulation
Female
Fenoterol
Hungary
In Vitro
Male
Myometrium
pharmacology
physiology
Puerperium
Radioligand Assay
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, alpha
Receptors, Adrenergic, alpha-1
Receptors, Adrenergic, beta
Support, Non-U.S.Gov't
Synapses
Terbutaline
ultrastructure
Uterine Contraction
Uterus
Megjelenés:Life Sciences. - 62 : 12 (1998), p. 1119-1124. -
További szerzők:Márki A. Zupkó István Falkay György
Internet cím:elektronikus változat
elektronikus változat
Borító:
Rekordok letöltése1