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001-es BibID:	BIBFORM074251
035-os BibID:	(cikkazonosító)744 (WOS)000429953200001 (Scopus)85045321936
Első szerző:	Bakti Fruzsina
Cím:	Heavy metal induced expression of PcaA provides cadmium tolerance to Aspergillus fumigatus and supports its virulence in the Galleria mellonella model / Fruzsina Bakti, Christoph Sasse, Thorsten Heinekamp, István Pócsi, Gerhard H. Braus
Dátum:	2018
ISSN:	1664-302X
Megjegyzések:	Most of the metal transporters in Aspergillus fumigatus are yet uncharacterized. Their role in fungal metabolism and virulence remains unclear. This paper describes the novel PIB-type cation ATPase PcaA, which links metal homeostasis and heavy metal tolerance in the opportunistic human pathogen A. fumigatus. The protein possesses conserved ATPase motif and shares 51% amino acid sequence identity with the Saccharomyces cerevisiae cadmium exporter Pca1p. A pcaA deletion, an overexpression and a gfp-pcaA complementation strain of A. fumigatus were constructed and their heavy metal susceptibilities were studied. The pcaA knock out strain showed drastically decreased cadmium tolerance, however, its growth was not affected by the exposure to high concentrations of copper, iron, zinc, or silver ions. Although the lack of PcaA had no effect on copper adaption, we demonstrated that not only cadmium but also copper ions are able to induce the transcription of pcaA in A. fumigatus wild type Af293. Similarly, cadmium and copper ions could induce the copper exporting ATPase crpA. These data imply a general response on the transcriptomic level to heavy metals in A. fumigatus through the induction of detoxification systems. Confocal microscopy of the gfp-pcaA complementation strain expressing functional GFP-PcaA supports the predicted membrane localization of PcaA. The GFP-PcaA fusion protein is located in the plasma membrane of A. fumigatus in the presence of cadmium ions. Virulence assays support a function of PcaA for virulence of A. fumigatus in the Galleria mellonella wax moth larvae model, which might be linked to the elimination of reactive oxygen species.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk gene cluster biosynthetic
Megjelenés:	Frontiers in Microbiology. - 9 (2018), p. [11]. -
További szerzők:	Sasse, Christoph Heinekamp, Thorsten Pócsi István (1961-) (vegyész) Braus, Gerhard
Pályázati támogatás:	TÁMOP-4.2.4B/2-11/1-2012-0001 TÁMOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM018754
Első szerző:	Wortman, Jennifer Russo
Cím:	The 2008 update of the Aspergillus nidulans genome annotation : A community effort / Jennifer Russo Wortman, Jane Mabey Gilsenan, Vinita Joardar, Jennifer Deegan, John Clutterbuck, Mikael R. Andersen, David Archer, Mojca Bencina, Gerhard Braus, Pedro Coutinho, Hans von Döhren, John Doonan, Arnold J.M. Driessen, Pawel Durek, Eduardo Espeso, Erzsébet Fekete, Michel Flipphi, Carlos Garcia Estrada, Steven Geysens, Gustavo Goldman, Piet W.J. de Groot, Kim Hansen, Steven D. Harris, Thorsten Heinekamp, Kerstin Helmstaedt, Bernard Henrissat, Gerald Hofmann, Tim Homan, Tetsuya Horio, Hiroyuki Horiuchi, Steve James, Meriel Jones, Levente Karaffa, Zsolt Karányi, Masashi Kato, Nancy Keller, Diane E. Kelly, Jan A.K.W. Kiel, Jung-Mi Kim, Ida J. van der Klei, Frans M. Klis, Andriy Kovalchuk, Nada Kraševec, Christian P. Kubicek, Bo Liu, Andrew MacCabe, Vera Meyer, Pete Mirabito, Márton Miskei, Magdalena Mos, Jonathan Mullins, David R. Nelson, Jens Nielsen, Berl R. Oakley, Stephen A. Osmani, Tiina Pakula, Andrzej Paszewski, Ian Paulsen, Sebastian Pilsyk, István Pócsi, Peter J. Punt, F.J. Ram, Qinghu Ren, Xavier Robellet, Geoff Robson, Bernhard Seiboth, Piet van Solingen, Thomas Specht, Jibin Sun, Naimeh Taheri-Talesh, Norio Takeshita, Dave Ussery, Patricia A. van Kuyk, Hans Visser, Peter J.I. van de Vondervoort, Ronald P. de Vries, Jonathan Walton, Xin Xiang, Yi Xiong, An Ping Zeng, Bernd W. Brandt, Michael J. Cornell, Cees A.M.J.J. van den Hondely, Jacob Visser, Stephen G. Oliver, Geoffrey Turner
Dátum:	2009
ISSN:	1087-1845
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Fungal Genetics And Biology. - 46 : 1 (2009), p. 2-13. -
További szerzők:	Gilsenan, Jane Mabey Joardar, Vinita Deegan, Jennifer Clutterbuck, John Andersen, Mikael R. Archer, David Bencina, Mojca Braus, Gerhard Coutinho, Pedro M. Döhren, Hans Von Doonan, John Driessen, Arnold J. M. Durek, Pawel Espeso, Eduardo Fekete Erzsébet (1975-) (biotechnológus, egyetemi tanár) Flipphi, Michel (1964-) Estrada, Carlos Garcia Geysens, Steven Goldman, Gustavo Groot, Piet W. J. de Hansen, Kim Harris, Steven D. Heinekamp, Thorsten Helmstaedt, Kerstin Henrissat, Bernard Hofmann, Gerald Homan, Tim Horio, Tetsuya Horiuchi, Hiroyuki James, Steve Jones, Meriel Karaffa Levente (1971-) (biotechnológus, egyetemi tanár) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Kato, Masashi Keller, Nancy Kelly, Diane E. Kiel, Jan A.K.W. Kim, Jung-Mi Klei, Ida J. van der Klis, Frans M. Kovalchuk, Andriy Kraševec, Nada Kubicek, Christian P. Liu, Bo MacCabe, Andrew Meyer, Vera Mirabito, Pete Miskei Márton (1978-) (molekuláris biológus, genetikus) Mos, Magdalena Mullins, Jonathan Nelson, David R. Nielsen, Jens Oakley, Berl R. Osmani, Stephen A. Pakula, Tiina Paszewski, Andrzej Paulsen, Ian Pilsyk, Sebastian Pócsi István (1961-) (vegyész) Punt, Peter J. Ram, Arthur F.J. Ren, Qinghu Robellet, Xavier Robson, Geoff Seiboth, Bernhard Solingen, Piet van Specht, Thomas Sun, Jibin Taheri-Talesh, Naimeh Takeshita, Norio Ussery, Dave Kuyk, Patricia A. van Visser, Hans Vondervoort, Peter J. I. van de De Vries, Ronald P. Walton, Jonathan Xiang, Xin Xiong, Yi Zeng, An Ping Brandt, Bernd W. Cornell, Michael J. Hondely, Cees A.M.J.J. van den Visser, Jacob Oliver, Stephen G. Turner, Geoffrey
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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