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001-es BibID:BIBFORM014319
Első szerző:Clausen, Tobias
Cím:Influence of moderate and profound hyperventilation on cerebral blood flow, oxygenation and metabolism / Clausen T., Scharf A., Menzel M., Soukup J., Holz C., Rieger A., Hanisch F., Bráth E., Németh N., Mikó I., Vajkoczy P., Radke J., Henze D.
Dátum:2004
ISSN:0006-8993
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Brain Research. - 1019 : 1-2 (2004), p. 113-123. -
További szerzők:Scharf, Alexander Menzel, Matthias (sebész) Soukup, Jens Holz, Carsten Rieger, Andreas Hanisch, Frank Bráth Endre (1969-) (kutatósebész) Németh Norbert (1975-) (kutatóorvos) Mikó Irén (1948-) (kutató sebész) Vajkoczy Péter Radke, Joachim Henze, Dirk
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2.

001-es BibID:BIBFORM046017
Első szerző:Menzel, Matthias (sebész)
Cím:Brain tissue oxygen monitoring for assessment of autoregulation : preliminary results suggest a new hypothesis / Menzel M., Soukup J., Henze D., Clausen T., Marx T., Hillman A., Mikó I., Grond S., Rieger A.
Dátum:2003
ISSN:0898-4921
Megjegyzések:Brain tissue oxygen monitoring (P(ti)O2 (Neurotrend, Codman, Germany) was employed in addition to standard intracranial pressure (ICP) and cerebral perfusion pressure (CPP) monitoring in seven patients with severe neuronal damage of heterogeneous etiology. The correlation between P(ti)O2 changes and CPP fluctuations during periods of 30 minutes were analyzed, when CPP was above 70 mmHg and lower than 100 mmHg. A new ratio, the CPP-oxygen-reactivity (COR) index was calculated as COR=delta p(ti)O2 %/delta CPP%. The patient COR values were compared to those found in the brain of six noninjured anesthetized piglets. The analysis was performed to determine the significance of synchronous fluctuations of CPP and P(ti)O2, when CPP is above the lower threshold of autoregulation. The correlation between CPP variations and p(ti)O2 variations was found to be strong (R(mean)) = 0.74 +/- 0.17) in the patients and was weak in the uninjured animals (R(mean)) =0.38 +/- 0.43). The COR (mean) was 2.05 +/- 0.57 in patients and 0.78 +/- 0.6 in the animals. In the injured brain of our patients, we observed an unexpectedly close correlation between P(ti)O2 and CPP variations when CPP levels were within a therapeutically targeted range (70 to 100 mmHg). In a porcine model, we could not find this relationship in the noninjured brain. We speculate that an increased COR might be indicative for an impaired local pressure autoregulation. The preliminary data suggest that COR values above "1" might be pathologic. However, the reported sample sizes are too small to provide sufficient statistical power to justify inferential statistical analyses. As such, results are presented with descriptive statistics only, and should be regarded as a hypothesis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neurosurgical Anesthesiology. - 15 : 1 (2003), p. 33-44. -
További szerzők:Soukup, Jens Henze, Dirk Clausen, Tobias Marx, T. Hillman, A. Mikó Irén (1948-) (kutató sebész) Grond, S. Rieger, Andreas
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3.

001-es BibID:BIBFORM030927
Első szerző:Németh Norbert (kutatóorvos)
Cím:Local and systemic hemorheological effects of cerebral hyper- and hypoperfusion in a porcine model / Németh N., Soukup J., Menzel M., Henze D., Clausen T., Rieger A., Holz C., Scharf A., Hanisch F., Furka I., Mikó I.
Dátum:2006
ISSN:1386-0291
Megjegyzések:Using a well defined pig model, we investigated whether cerebral hypertension and hypotension influence hemorheological factors. After surgical preparation and stabilization, periods of hyperventilation, controlled periods of cerebral perfusion pressure increases and decreases were utilized. After each period, blood samples were collected from the cannulated femoral artery and vein, and from the superior sagittal sinus. Erythrocyte deformability, whole blood and plasma viscosity and hematological parameters were determined. Erythrocyte deformability significantly worsened in arterial samples after hypertension and hypotension, and in sinus samples it was impaired after hypotension period. Hematocrit significantly increased in arterial and sinus samples during hypertensive period, accompanied by similar alterations in whole blood viscosity. We conclude that hemodynamic changes caused by hyperventilation, hyper- or hypotension can influence hemorheological factors, and suggest that the rheological alterations can affect local hemodynamic and metabolic conditions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical Hemorheology And Microcirculation. - 35 : 1-2 (2006), p. 59-65. -
További szerzők:Soukup, Jens Menzel, Matthias (sebész) Henze, Dirk Clausen, Tobias Rieger, Andreas Holz, Carsten Scharf, Alexander Hanisch, Frank Furka István (1935-2021) (sebész, urológus, kutatóorvos) Mikó Irén (1948-) (kutató sebész)
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