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1.

001-es BibID:BIBFORM014319
Első szerző:Clausen, Tobias
Cím:Influence of moderate and profound hyperventilation on cerebral blood flow, oxygenation and metabolism / Clausen T., Scharf A., Menzel M., Soukup J., Holz C., Rieger A., Hanisch F., Bráth E., Németh N., Mikó I., Vajkoczy P., Radke J., Henze D.
Dátum:2004
ISSN:0006-8993
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Brain Research. - 1019 : 1-2 (2004), p. 113-123. -
További szerzők:Scharf, Alexander Menzel, Matthias (sebész) Soukup, Jens Holz, Carsten Rieger, Andreas Hanisch, Frank Bráth Endre (1969-) (kutatósebész) Németh Norbert (1975-) (kutatóorvos) Mikó Irén (1948-) (kutató sebész) Vajkoczy Péter Radke, Joachim Henze, Dirk
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2.

001-es BibID:BIBFORM046017
Első szerző:Menzel, Matthias (sebész)
Cím:Brain tissue oxygen monitoring for assessment of autoregulation : preliminary results suggest a new hypothesis / Menzel M., Soukup J., Henze D., Clausen T., Marx T., Hillman A., Mikó I., Grond S., Rieger A.
Dátum:2003
ISSN:0898-4921
Megjegyzések:Brain tissue oxygen monitoring (P(ti)O2 (Neurotrend, Codman, Germany) was employed in addition to standard intracranial pressure (ICP) and cerebral perfusion pressure (CPP) monitoring in seven patients with severe neuronal damage of heterogeneous etiology. The correlation between P(ti)O2 changes and CPP fluctuations during periods of 30 minutes were analyzed, when CPP was above 70 mmHg and lower than 100 mmHg. A new ratio, the CPP-oxygen-reactivity (COR) index was calculated as COR=delta p(ti)O2 %/delta CPP%. The patient COR values were compared to those found in the brain of six noninjured anesthetized piglets. The analysis was performed to determine the significance of synchronous fluctuations of CPP and P(ti)O2, when CPP is above the lower threshold of autoregulation. The correlation between CPP variations and p(ti)O2 variations was found to be strong (R(mean)) = 0.74 +/- 0.17) in the patients and was weak in the uninjured animals (R(mean)) =0.38 +/- 0.43). The COR (mean) was 2.05 +/- 0.57 in patients and 0.78 +/- 0.6 in the animals. In the injured brain of our patients, we observed an unexpectedly close correlation between P(ti)O2 and CPP variations when CPP levels were within a therapeutically targeted range (70 to 100 mmHg). In a porcine model, we could not find this relationship in the noninjured brain. We speculate that an increased COR might be indicative for an impaired local pressure autoregulation. The preliminary data suggest that COR values above "1" might be pathologic. However, the reported sample sizes are too small to provide sufficient statistical power to justify inferential statistical analyses. As such, results are presented with descriptive statistics only, and should be regarded as a hypothesis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neurosurgical Anesthesiology. - 15 : 1 (2003), p. 33-44. -
További szerzők:Soukup, Jens Henze, Dirk Clausen, Tobias Marx, T. Hillman, A. Mikó Irén (1948-) (kutató sebész) Grond, S. Rieger, Andreas
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3.

001-es BibID:BIBFORM055462
Első szerző:Menzel, Matthias (sebész)
Cím:Comparison between continuous measurement of pO2, pCO2 and pH in brain tissue and cerebrovenous blood / M. Menzel, A. Rieger, J. Soukup, S. Roth, I. Furka, I. Mikó, P. Molnár, J. Radke
Dátum:1998
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Zentralblatt fur Neurochirurgie. - 59 (1998), p. 207. -
További szerzők:Rieger, Andreas Soukup, Jens Roth, Stephan Furka István (1935-2021) (sebész, urológus, kutatóorvos) Mikó Irén (1948-) (kutató sebész) Molnár Péter Pál (1951-) (pathológus) Radke, Joachim
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4.

001-es BibID:BIBFORM055463
Első szerző:Menzel, Matthias (sebész)
Cím:Temperature of the Cerebrovascular Blood in a Model of Increased Intracranial Pressure / M. Menzel, A. Rieger, J. Soukup, S. Roth, I. Furka, I. Mikó, C. Hennig, P. Molnár, J. Radke
Dátum:1998
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Anesthesia and Analgesia. - 1 (1998), p. 94. -
További szerzők:Rieger, Andreas Soukup, Jens Roth, Stephan Furka István (1935-2021) (sebész, urológus, kutatóorvos) Mikó Irén (1948-) (kutató sebész) Hennig, Christian Molnár Péter Pál (1951-) (pathológus) Radke, Joachim
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5.

001-es BibID:BIBFORM030999
Első szerző:Menzel, Matthias (sebész)
Cím:Continuous Monitoring of p02, PCO2, pH and temperature in Cerebral Venous Blood - Evaluation in a Porcine Study and in Man / Menzel M., Rieger A., Furka I., Miko I., Roth S., Soukup J., Trommler P., Burkert W., Radke J.
Dátum:1996
Tárgyszavak:Orvostudományok Klinikai orvostudományok konferenciacikk
Megjelenés:Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie. - 31 (1996), p. 449-450. -
További szerzők:Rieger, Andreas Furka István (1935-2021) (sebész, urológus, kutatóorvos) Mikó Irén (1948-) (kutató sebész) Roth, Stephan Soukup, Jens Trommler, P. Burkert, Winfried Radke, Joachim
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6.

001-es BibID:BIBFORM017221
035-os BibID:PMID: 9555972
Első szerző:Menzel, Matthias (sebész)
Cím:Comparison between continuous brain tissue pO2, pCO2, pH, and temperature and simultaneous cerebrovenous measurement using a multisensor probe in a porcine intracranial pressure model / Menzel M., Rieger A., Roth S., Soukup J., Furka I., Mikó I., Molnár P., Peuse C., Hennig C., Radke J.
Dátum:1998
Megjegyzések:Local brain tissue oxygenation (p(ti)O2) and global cerebrovenous hemoglobin saturation (SjO2) are increasingly used to continuously monitor patients after severe head injury (SHI). In patients, simultaneous local and global oxygen measurements of these types have shown different results regarding the comparability of the findings during changes in CPP and ICP. This is in contrast to theoretical expectations. The aim of this study was to compare p(ti)O2 measurement with cerebrovenous oxygen partial pressure measurement (p(cv)O2) in an animal intracranial pressure model. To this end, a multisensor probe was placed in the left frontoparietal white matter to measure p(ti)O2, pCO2 (p(ti)CO2), pH (pH[ti]), and temperature (t[ti]) while simultaneously measuring these same parameters (p(cv)O2, p(cv)CO2 pH(cv), t[cv]) in the sagittal sinus of 9 pigs under general anesthesia. By stepwise inflating a balloon catheter, placed in supracerebellar infratentorial compartment, ICP was increased and CPP was decreased. The baseline levels of p(ti)O2, p(ti)CO2, and pH(ti) in the noninjured brain tissue showed more heterogeneity compared to the findings in cerebrovenous blood. Both, p(ti)O2 and p(cv)O2 were significantly correlated to the induced CPP decrease. PCO2 was inversely correlated to the course of CPP in both measurement compartments. Temperature measurement showed a positive correlation with CPP in both compartments. These findings demonstrate that brain tissue oximetry and cerebrovenous PO2 measurement are sensitive to CPP changes. The newly available continuous parameters in multisensor probes could be helpful in interpreting findings of cerebral oxygen measurement in man by analyzing the interrelationship of these parameters.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of neurotrauma. - 15 : 4 (1998), p. 265-276. -
További szerzők:Rieger, Andreas Roth, Stephan Soukup, Jens Furka István (1935-2021) (sebész, urológus, kutatóorvos) Mikó Irén (1948-) (kutató sebész) Molnár Péter Pál (1951-) (pathológus) Peuse, C. Hennig, Christian Radke, Joachim
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7.

001-es BibID:BIBFORM017870
Első szerző:Menzel, Matthias (sebész)
Cím:Temperature of the cerebrovenous blood in a model of increased intracranial pressure / M. Menzel, A. Rieger, J. Soukup, S. Roth, I. Furka, I. Miko, P. Molnar, C. Hennig, J. Radke
Dátum:1998
ISSN:0003-2417
Megjegyzések:Hypothermia has a considerable protective effect during brain ischemia. On the other hand small increases of brain temperature have a remarkable effect on the exacerbation of neurological damage following an ischemic event. Hyperthermia of the brain tissue after severe head injury is described. The effect of acutely increased intracranial pressure on cerebrovenous blood temperature is not described yet. The aim of this study was to investigate the relationship between temperature in the cerebrovenous compartment (Tcv) and changes of the CPP in an animal model of raised intracranial pressure. Methods: A thermocouple was inserted in the sagittal sinus in 9 pigs under general anesthesia. By stepwise inflating a supracerebral and infratentorial placed balloon catheter intracranial pressure (ICP) was increased and CPP concomitantly decreased. The central body temperature was measured simultaneously in the abdominal aorta (Ta) with a second thermocouple. Results: In our model th Tcv was lower than Ta at the beginning of the ICP increase. The mean difference between Ta and Tcv, (deltaTa-cv) was 0,86° C (±0,44) prior to ICP increase and 1,19° C (0,58) at the maximum ICP increase. Thus, deltaTav increased during CPP reduction. This relation was represented by an adjusted R(square) of r2=0.89 (p<0,001). Conclusions: The CPP decrease, caused by an increasing ICP, results in changes of the cerebrovenous blood temperature. Interpreting the present results the experimental situation of a relative colder cerebral compartment in comparison to the central body temperature has to be considered. However, the results imply, that simultaneous temperature monitoring of the central body temperature and the cerebrovenpus blood temperature is an additional source of information about relative changes of the CBF.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
open access
Brain
Temperature
Cerebrovenous
Monitoring
Cerebral blood flow
Megjelenés:Der Anaesthesist. - 47 : 7 (1998), p. 600-604. -
További szerzők:Rieger, Andreas Soukup, Jens Roth, Stephan Furka István (1935-2021) (sebész, urológus, kutatóorvos) Mikó Irén (1948-) (kutató sebész) Molnár Péter Pál (1951-) (pathológus) Hennig, Christian Radke, Joachim
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8.

001-es BibID:BIBFORM030927
Első szerző:Németh Norbert (kutatóorvos)
Cím:Local and systemic hemorheological effects of cerebral hyper- and hypoperfusion in a porcine model / Németh N., Soukup J., Menzel M., Henze D., Clausen T., Rieger A., Holz C., Scharf A., Hanisch F., Furka I., Mikó I.
Dátum:2006
ISSN:1386-0291
Megjegyzések:Using a well defined pig model, we investigated whether cerebral hypertension and hypotension influence hemorheological factors. After surgical preparation and stabilization, periods of hyperventilation, controlled periods of cerebral perfusion pressure increases and decreases were utilized. After each period, blood samples were collected from the cannulated femoral artery and vein, and from the superior sagittal sinus. Erythrocyte deformability, whole blood and plasma viscosity and hematological parameters were determined. Erythrocyte deformability significantly worsened in arterial samples after hypertension and hypotension, and in sinus samples it was impaired after hypotension period. Hematocrit significantly increased in arterial and sinus samples during hypertensive period, accompanied by similar alterations in whole blood viscosity. We conclude that hemodynamic changes caused by hyperventilation, hyper- or hypotension can influence hemorheological factors, and suggest that the rheological alterations can affect local hemodynamic and metabolic conditions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical Hemorheology And Microcirculation. - 35 : 1-2 (2006), p. 59-65. -
További szerzők:Soukup, Jens Menzel, Matthias (sebész) Henze, Dirk Clausen, Tobias Rieger, Andreas Holz, Carsten Scharf, Alexander Hanisch, Frank Furka István (1935-2021) (sebész, urológus, kutatóorvos) Mikó Irén (1948-) (kutató sebész)
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