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001-es BibID:	BIBFORM004855
Első szerző:	Bagdány Miklós
Cím:	Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes / Bagdany, M., Batista, C. V. F., Valdez-Cruz, N. A., Somodi, S., Rodriguez de la Vega, R. C., Licea, A. F., Varga, Z., Gaspar, R., Possani, L. D., Panyi, G.
Dátum:	2005
Megjegyzések:	The physiological function of T lymphocytes can be modulated selectively by peptide toxins acting on Kv1.3 K(+) channels. Because Kv1.3-specific peptide toxins are considered to have a significant therapeutic potential in the treatment of autoimmune diseases, the discovery of new toxins is highly motivated. Through chromatographic procedures and electrophysiological assays, using patch-clamp methodology, the isolation of a novel peptide named anuroctoxin was accomplished using the venom of the Mexican scorpion Anuroctonus phaiodactylus. It has 35 amino acid residues with a molecular weight of 4082.8, tightly bound by four disulfide bridges whose complete covalent structure was determined. It has a pyroglutamic acid at the N-terminal region and an amidated C-terminal residue. Sequence comparison and phylogenetic clustering analysis classifies anuroctoxin into subfamily 6 of the alpha-KTx scorpion toxins (systematic name, alpha-KTx 6.12). Patch-clamp experiments show that anuroctoxin is a high-affinity blocker of Kv1.3 channels of human T lymphocytes with a K(d) of 0.73 nM, and it does not block the Ca(2+)-activated IKCa1 K(+) channels. These two channels play different but important roles in T-lymphocyte activation. Furthermore, the toxin practically does not inhibit Shaker IR, mKv1.1, and rKv2.1 channels, whereas the affinity of anuroctoxin for hKv1.2 is almost an order of magnitude smaller than for Kv1.3. The pharmacological profile and the selectivity of this new toxin for Kv1.3 over IKCa1 may provide an important tool for the modulation of the immune system, especially in cases in which selective inhibition of Kv1.3 is required.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis Animals antagonists & inhibitors Autoimmune Diseases Biophysics chemistry drug effects Human Humans Hungary Immune System Intermediate-Conductance Calcium-Activated Potassium Channels Ion Channels isolation & purification Kv1.3 Potassium Channel Lymphocytes Models,Molecular Molecular Weight pharmacology Phylogeny Potassium Potassium Channel Blockers Potassium Channels Potassium Channels,Calcium-Activated Potassium Channels,Voltage-Gated Research Scorpion Venoms Sequence Alignment Support T-Lymphocytes Toxins Toxins,Biological
Megjelenés:	Molecular Pharmacology. - 67 : 4 (2005), p. 1034-1044. -
További szerzők:	Batista, Cesar V. F. Valdez-Cruz, Norma A. Somodi Sándor (1977-) (belgyógyász) Rodriguez de la Vega, Ricardo C. Licea, Alexei F. Varga Zoltán (1969-) (biofizikus, szakfordító) Gáspár Rezső (1944-) (biofizikus) Possani, Lourival Domingos Panyi György (1966-) (biofizikus)
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001-es BibID:	BIBFORM043018
035-os BibID:	PMID:22622363
Első szerző:	Varga Zoltán (biofizikus, szakfordító)
Cím:	Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells / Zoltan Varga, Georgina Gurrola-Briones, Ferenc Papp, Ricardo C. Rodríguez de la Vega, Gustavo Pedraza-Alva, Rajeev B. Tajhya, Rezso Gaspar, Luis Cardenas, Yvonne Rosenstein, Christine Beeton, Lourival D. Possani, Gyorgy Panyi
Dátum:	2012
Megjegyzések:	Blockade of Kv1.3 K(+) channels in T cells is a promising therapeutic approach for the treatment of autoimmune diseases such as multiple sclerosis and type 1 diabetes mellitus. Vm24 (alpha-KTx 23.1) is a novel 36-residue Kv1.3-specific peptide isolated from the venom of the scorpion Vaejovis mexicanus smithi. Vm24 inhibits Kv1.3 channels of human lymphocytes with high affinity (K(d) = 2.9 pM) and exhibits >1500-fold selectivity over other ion channels assayed. It inhibits the proliferation and Ca(2+) signaling of human T cells in vitro and reduces delayed-type hypersensitivity reactions in rats in vivo. Our results indicate that Vm24 has exceptional pharmacological properties that make it an excellent candidate for treatment of certain autoimmune diseases
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban article Autoimmune Diseases Biophysics cell biology Cells Human Hungary In Vitro Ion Channels Kv1.3 Potassium Channel lymphocyte Lymphocytes Multiple Sclerosis Potassium Potassium Channels Rats külföldön készült közlemény
Megjelenés:	Molecular Pharmacology. - 82 : 3 (2012), p. 372-382. -
További szerzők:	Gurrola-Briones, Georgina Papp Ferenc (1979-) (biofizikus) Rodríguez, Ricardo C. de la Vega Pedraza-Alva, Gustavo Tajhya, Rajeev B. Gáspár Rezső (1944-) (biofizikus) Cardenas, Luis Rosenstein, Yvonne Beeton, Christine Possani, Lourival Domingos Panyi György (1966-) (biofizikus)
Pályázati támogatás:	TÁMOP-4.2.2-08/1/2008-0019 TÁMOP TÁMOP-4.2.1/B-09/1/KONV-2010-007 TÁMOP TÁMOP-4.2.2-A-11/1/KONV-2012-0025 TÁMOP
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