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1.

001-es BibID:	BIBFORM067886
Első szerző:	Bácskai Tímea (biológus, neurobiológus)
Cím:	Effect of chronic fluorokinolone treatment on the structures innervating the salivary glands of the rat / Bácskai Tímea, Kelentey Barna, Deák Ádám, Zelles Tivadar, Skopkó Boglárka, Matesz Klára
Dátum:	2007
ISSN:	1065-6766
Megjegyzések:	Fluorokinolones (i.e. Peflacine, PEF) are used in the dental and medical therapy. It was demonstrated that chronic treatment on the rats resulted in disturbance in the secretory function of the salivary glands accompanied by the morphological sign of atrophy in the secretory units. The mechanism of this impairment is unknown. Because the peripheral neuropathy was previously described as the toxic side effect of the chronic PEF treatment we proposed that the morphological and funcional disorder of salivary glands developed on the basis of a neuronal disorder. Earlier studies described, that the mast cells could release nerve growth factor (NGF), which is important in the surviving of neurons. The lack of NGF results degenerative processes in the peripheral neurons which can change the expression of neuropeptides (i.e. serotonin, SER).The aim of this study was to determine the number of mast cells and the qualitative and quantitative changes of SER immunoreactive (IR) nerve terminals in the salivary glands after PEF treatment. Adult rats were treated with PEF for 3 and 7 days. For the visualization of mast cells we have used Toluidine blue staining. Immunohisthochemical methods were used to detect the SER containing fibers on the salivary glands. After the chronic treatment we could detect the incresed number of mast cells which supports the protective role of the NGF. The number of SER IR fibers decreased compared to the control. The changes in the number of IR fibers support our previous results, that local denervation of Salivary gland can cause the atrophy of the acini.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idézhető absztrakt saliva
Megjelenés:	Clinical Neuroscience. - 2007. (2007), p. 7. -
További szerzők:	Kelentey Barna (1959-) (fogszakorvos) Deák Ádám (1974-) (állatorvos) Zelles Tivadar Skopkó Boglárka Emese (1986-) (fogszakorvos) Matesz Klára (1949-) (anatómus, neurobiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:	BIBFORM067884
Első szerző:	Bácskai Tímea (biológus, neurobiológus)
Cím:	Effect of fluorokinolone treatment on the peptidergic innervation of the salivary glands / Tímea Bácskai, Barna Kelentey, Ádám Deák, Tivadar Zelles, Boglárka Skopkó, Klara Matesz
Dátum:	2010
Megjegyzések:	Fluorokinolones (i.e. Peflacine, PEF) are used in the dental and medical therapy. It was demonstrated that chronic treatment on the rats resulted in disturbance in the secretory function of the salivary glands accompanied by the morphological sign of atrophy in the secretory units. The mechanism of this impairment is unknown. Because the peripheral neuropathy was previously described as the toxic side effect of the chronic PEF treatment we proposed that the morphological and functional disorder of salivary glands developed on the basis of a neuronal disorder. Earlier studies described, that the mast cells could release nerve growth factor (NGF), which is important in the surviving of neurons. The lack of NGF results degenerative processes in the peripheral neurons which can change the expression of neuropeptides (i.e. serotonine, SER). The aim of this study was to determine the number of mast cells and the qualitative and quantitative changes of SER immunoreactive (IR) nerve terminals in the salivary glands after PEF treatment. Adult rats were treated with PEF for 3 and 7 days. For the visualization of mast cell we have used Toluidine blue staining. Immunohistochemical methods were used to detect the SER containing fibers on the salivary glands. After the chronic treatment we could detect the increased number of mast cells which supports the protective role of the NGF. The number of SER IR fibers decreased compared to the control. The changes in the number of IR fibers support our previous results, that local denervation of salivary gland can cause the atrophy of the acini. taa (hibás)
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idézhető absztrakt saliva
Megjelenés:	Frontiers in Neuroscience 2010 (2010), p. 1. -
További szerzők:	Kelentey Barna (1959-) (fogszakorvos) Deák Ádám (1974-) (állatorvos) Zelles Tivadar Skopkó Boglárka Emese (1986-) (fogszakorvos) Matesz Klára (1949-) (anatómus, neurobiológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:	BIBFORM029718
Első szerző:	Baker, R. E.
Cím:	Peripheral reinnervation patterns and dorsal root ganglion topography in skin-grafted frogs : a behavioral and histological examination / Baker R. E., Matesz K., Corner M. A., Székely G.
Dátum:	1981
ISSN:	0378-5866
Megjegyzések:	Behavioral responses to mechanical stimulation of the skin were observed in unoperated, 180 degrees skin-rotated and sham-grafted Rana pipiens frogs before and after crushing various cutaneous nerve bundles. In the two control groups, wiping responses directed towards the animal's dorsum were mediated solely via dorsomedial (DM) and dorsolateral (DL) nerve trunks. In skin-rotated frogs, DM and DL nerve trunks were responsible for almost all of the misdirected responses elicited from dorsal cutaneous areas. Six frogs (2 sham- and 4 skin-rotated) possessed some areas of plical skin from which responses could only have been mediated via more ventrally located nerve trunks. However, such dorsal expansions of ventral receptive fields never included the midline skin areas from which misdirected responses had been elicited in the intact animal. The topographic arrangement of cells within the DRG appears to be weakly polarized in cobalt-stained sections, but with large individual variations in size and observed number of neuronal profiles. For the skin-rotated group the ratio of cobalt-filled profiles in the dorsal as compared with the ventral half of the ganglion was 1.6, which did not differ significantly from the control value of 1.9. Taken as a whole, the results of the present study indicate that selective (re)innervation of displaced skin by the original nerve fibers cannot explain the origin of misdirected responses in Rana pipiens.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Developmental Neuroscience. - 4 : 2 (1981), p. 134-141. -
További szerzők:	Matesz Klára (1949-) (anatómus, neurobiológus) Corner, M. A. Székely György (1926-2017) (neurobiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:	BIBFORM030292
Első szerző:	Deák Ádám (állatorvos)
Cím:	Effect of unilateral labyrinthectomy on the molecular composition of perineuronal nets in the lateral vestibular nucleus of the rat / Ádám Deák, Tímea Bácskai, Botond Gaál, Éva Rácz, Klára Matesz
Dátum:	2012
ISSN:	0304-3940
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neuroscience Letters. - 513 : 1 (2012), p. 1-5. -
További szerzők:	Bácskai Tímea (1974-) (biológus, neurobiológus) Gaál Botond Ágoston (1982-) (anatómus, neurobiológus) Rácz Éva (1982-) (biológus) Matesz Klára (1949-) (anatómus, neurobiológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:	BIBFORM109585
035-os BibID:	(cikkazonosító)1115685 (Scopus)85150718609 (WoS)000951373400001
Első szerző:	Ducza László (molekuláris biológus)
Cím:	Neuronal P2X4 receptor may contribute to peripheral inflammatory pain in rat spinal dorsal horn / Ducza László, Gajtkó Andrea, Hegedűs Krisztina, Bakk Erzsébet, Kis Gréta, Gaál Botond, Takács Roland, Szücs Péter, Matesz Klára, Holló Krisztina
Dátum:	2023
ISSN:	1662-5099
Megjegyzések:	Objective: Intense inflammation may result in pain, which manifests as spinal central sensitization. There is growing evidence that purinergic signaling plays a pivotal role in the orchestration of pain processing. Over the last decade the ionotropic P2X purino receptor 4 (P2X4) got into spotlight in neuropathic disorders, however its precise spinal expression was scantily characterized during inflammatory pain. Thus, we intended to analyze the receptor distribution within spinal dorsal horn and lumbar dorsal root ganglia (DRG) of rats suffering in inflammatory pain induced by complete Freund adjuvant (CFA). Methods: CFA-induced peripheral inflammation was validated by mechanical and thermal behavioral tests. In order to ensure about the putative alteration of spinal P2X4 receptor gene expression qPCR reactions were designed, followed by immunoperoxidase and Western blot experiments to assess changes at a protein level. Colocalization of P2X4 with neuronal and glial markers was investigated by double immunofluorescent labelings, which were subsequently analyzed with IMARIS software. Transmission electronmicroscopy was applied to study the ultrastructural localization of the receptor. Concurrently, in lumbar DRG cells similar methodology has been carried out to complete our observations. Results: The figures of mechanical and thermal behavioral tests proved the establishment of CFA-induced inflammatory pain. We observed significant enhancement of P2X4 transcript level within the spinal dorsal horn 3?days upon CFA administration. Elevation of P2X4 immunoreactivity within Rexed lamina I-II of the spinal gray matter was synchronous with mRNA expression, and confirmed by protein blotting. According to IMARIS analysis the robust protein increase was mainly detected on primary afferent axonterminals and GFAP-labelled astrocyte membrane compartments, but not on postsynaptic dendrites was also validated ultrastructurally within the spinal dorsal horn. Furthermore, lumbar DRG analysis demonstrated that peptidergic and non-peptidergic nociceptive subsets of ganglia cells were also abundantly positive for P2X4 receptor in CFA model. Conclusion: Here we provide novel evidence about involvement of neuronal and glial P2X4 receptor in the establishment of inflammatory pain.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk inflammatory pain spinal dorsal horn P2X4 receptor central sensitization primary afferents glial cells dorsal root ganglia
Megjelenés:	Frontiers in Molecular Neuroscience. - 16 (2023), p. 1-16. -
További szerzők:	Gajtkó Andrea (1989-) (molekuláris biológus) Hegedűs Krisztina Bakk Erzsébet Kis Gréta (1979-) (molekuláris biológus) Gaál Botond Ágoston (1982-) (anatómus, neurobiológus) Takács Roland Ádám (1985-) (molekuláris biológus, biokémikus) Szűcs Péter (1974-) (kutatóorvos) Matesz Klára (1949-) (anatómus, neurobiológus) Holló Krisztina (1967-) (vegyész)
Pályázati támogatás:	KTIA_NAP_13-2-2014-0005 Egyéb 2017-1.2.1-NKP-2017-00002 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:	BIBFORM064344
Első szerző:	Gaál Botond Ágoston (anatómus, neurobiológus)
Cím:	Molecular composition and expression pattern of the extracellular matrix in a mossy fiber-generating precerebellar nucleus of rat, the prepositus hypoglossi / Botond Gaál, Szilvia Kecskes, Clara Matesz, Andras Birinyi, Andrea Hunyadi, Éva Rácz
Dátum:	2015
ISSN:	0304-3940
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neuroscience Letters. - 594 (2015), p. 122-126. -
További szerzők:	Kecskés Szilvia (1984-) (anatómus, neurobiológus) Matesz Klára (1949-) (anatómus, neurobiológus) Birinyi András (1960-) (anatómus, neurobiológus) Hunyadi Andrea (1979-) (molekuláris biológus) Rácz Éva (1982-) (biológus)
Pályázati támogatás:	MTA-TKI 11008 MTA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:	BIBFORM052624
Első szerző:	Gaál Botond Ágoston (anatómus, neurobiológus)
Cím:	Distribution of extracellular matrix macromolecules in the vestibular nuclei and cerebellum of the frog, Rana esculenta / B. Gaál, É. Rácz, T. Juhász, K. Holló, C. Matesz
Dátum:	2014
ISSN:	0306-4522
Megjegyzések:	The axons of transected and re-apposed vestibulocochlear nerve of the frog, in contrast to mammalian species, regenerate and establish functional contacts within their original termination areas of the vestibular nuclear complex and the cerebellum. The lack of regenerative capability of the mammalian central nervous system (CNS) is partially attributed to various extracellular matrix (ECM) molecules, such as chondroitin sulfate proteoglycans (CSPG) and tenascin-R (TN-R), which exert inhibition on axon regeneration. In contrast to these molecules, hyaluronan (HA) was reported to be permissive for CNS regeneration. Using histochemical and immunohistochemical methods, we investigated the distribution pattern of these molecules in the medial (MVN), lateral (LVN), superior and descending vestibular nuclei and the cerebellum of the frog and detected regional differences in the organization of the ECM. In the vestibular nuclear complex, pericellular condensation of the ECM, the perineuronal nets (PNNs) were recognizable in the LVN and MVN and were positive only for HA. The neuropil of the vestibular nuclei showed either a diffuse appearance with varying intensity of reactions, or dots and ring-like structures, which may represent the perinodal ECM of the vestibular fibers. In the cerebellum, indistinct PNNs that were only labeled for HA were present in the granular layer. Our findings suggest that the HA-rich, but CSPG and TN-R-free PNNs may be associated with the high degree of plasticity and regenerative potential of the amphibian vestibular system.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban perineuronal net hyaluronan chondroitin sulfate proteoglycan tenascin-R neural plasticity brainstem Doktori iskola
Megjelenés:	Neuroscience. - 258 (2014), p. 162-173. -
További szerzők:	Rácz Éva (1982-) (biológus) Juhász Tamás (1976-) (biológus, orvosbiológus) Holló Krisztina (1967-) (vegyész) Matesz Klára (1949-) (anatómus, neurobiológus)
Pályázati támogatás:	MTA-TKI-11008 MTA TÁMOP-4.2.2/B-10/1-2010-0024 TÁMOP Fogorvostudományi Doktori Iskola TÁMOP-4.2.4. A/2-11-1-2012-0001 TÁMOP
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8.

001-es BibID:	BIBFORM056617
Első szerző:	Kecskés Szilvia (anatómus, neurobiológus)
Cím:	Extracellular matrix molecules exhibit unique expression pattern in the climbing fiber-generating precerebellar nucleus, the inferior olive / S. Kecskes, B. Gaál, É. Rácz, A. Birinyi, A. Hunyadi, C. Matesz
Dátum:	2015
ISSN:	0306-4522
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neuroscience. - 284 (2015), p. 412-421. -
További szerzők:	Gaál Botond Ágoston (1982-) (anatómus, neurobiológus) Rácz Éva (1982-) (biológus) Birinyi András (1960-) (anatómus, neurobiológus) Hunyadi Andrea (1979-) (molekuláris biológus) Matesz Klára (1949-) (anatómus, neurobiológus)
Pályázati támogatás:	MTA-DE MTA Idegtudományi Kutatócsoport 4.2.4.A/2-11-1-2012-0001. TÁMOP
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9.

001-es BibID:	BIBFORM029513
Első szerző:	Matesz Klára (anatómus, neurobiológus)
Cím:	Development of the oculomotor and trochlear nuclei in the Xenopus toad / Clara Matesz
Dátum:	1990
Megjegyzések:	The development of the oculomotor and trochlear nuclei (nIII and nIV) was studied with the horseradish peroxidase (HRP) and the cobalt labelling techniques in Xenopus laevis tadpoles. The earliest labelling of the oculomotor neuroblasts was observed at stage 32. The ipsi- and contralateral nuclei were found in two distinct groups on either side of the brainstem and the oculomotor commissure formed by crossing axons was present at this early stage. The fusion of the two nuclei began at the late larval stage when the axonal outgrowth had been presumably completed. The trochlear neuroblasts could be first labelled at stage 39 when the position of the nucleus and axonal pathway was similar to the adult form.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neuroscience Letters. - 116 : 1-2 (1990), p. 1-6. -
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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10.

001-es BibID:	BIBFORM029515
Első szerző:	Matesz Klára (anatómus, neurobiológus)
Cím:	Investigation of the dendritic geometry of brain stem motoneurons with different functions using multivariant multistatistical techniques in the frog / Matesz K., Birinyi A., Kothalawala D. S., Székely G.
Dátum:	1995
ISSN:	0306-4522
Megjegyzések:	We give an account of an effort to make quantitative morphological distinctions between motoneurons innervating functionally different muscles in the trigeminal and facial motor nuclei of the frog. Six groups of neurons were considered in the two nuclei on the basis of their peripheral targets. One group consisted of neurons (n = 7) innervating the levator bulbi muscle, which separates the orbital cavity from the oral cavity. In the second, third and fourth groups, motoneurons (n = 27) innervating jaw closer muscles (temporalis, masseter, pterygoideus) were studied. Neurons (n = 6) innervating the submaxillary muscle comprised the fifth group. This muscle forms the muscular floor of the mouth. It is active in deglutition and contributes to the opening of the mouth. The sixth group is formed by neurons of the facial nucleus (n = 7), which innervate the depressor mandibulae muscle. This is the main opener of the mouth. Neurons were selectively stained by cobalt labelling through the muscle nerves and the morphometric values of successfully labelled neurons were fed into a IBM AT 386 computer through a digitizing tablet for three-dimensional reconstruction. Four neurons labelled directly through the motor root of the trigeminal nerve but innervating unidentified muscles were added to the investigation. Two sets of quantitative measurements were taken from the neurons. In the first set (neurometric data), 17 quantitative variables were measured in the perikaryon and the dendritic arbor. In the second set, 15 variables concerned with the orientation and shape of the dendritic tree, the relation of the perikaryon to the dendritic tree and the spatial expansion of dendrites were measured in the three dimensions of Cartesian space (product-moment data). The data were subjected to multivariant statistical analysis. First, they were partitioned with cluster analysis. The average linkage between groups algorithm and the cosine of vectors of variables, or the Pearson correlation similarity coefficients were used. Neurometric data and product-moment data were analysed separately and in combination, and six to seven clusters were considered. In each case, the majority of neurons innervating jaw closer muscles were grouped into clusters different from neurons innervating jaw opener muscles. The best separation of functionally different neurons was achieved with the neurometric data set. The groups of neurons obtained from cluster analysis were subjected to non-parametric discriminant analysis with the eight nearest-neighbour classification criterion, and the results were checked with a cross-validation technique.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neuroscience. - 65 : 4 (1995), p. 1129-1144. -
További szerzők:	Birinyi András (1960-) (anatómus, neurobiológus) Kothalawala, D. S. Székely György (1926-2017) (neurobiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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11.

001-es BibID:	BIBFORM029517
Első szerző:	Matesz Klára (anatómus, neurobiológus)
Cím:	Peripheral and central distribution of fibers of the mesencephalic trigeminal root in the rat / Matesz K.
Dátum:	1981
Megjegyzések:	Using the cobalt labelling technique in the rat, mesencephalic afferent fibres were shown in all three divisions of the trigeminal nerve. The descending branches of mesencephalic trigeminal neurones extend to the 3rd cervical segment of the spinal cord. Collaterals of this tract terminate in the following structures: the supratrigeminal nucleus, the motor nuclei of V, VII and XII cranial nerves, the reticular formation, a distinct nucleus in the reticular formation and the solitary nucleus.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neuroscience Letters. - 27 : 1 (1981), p. 13-17. -
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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12.

001-es BibID:	BIBFORM029516
Első szerző:	Matesz Klára (anatómus, neurobiológus)
Cím:	Central projections of the VIIIth cranial nerve in the frog / Matesz K.
Dátum:	1979
ISSN:	0306-4522
Megjegyzések:	With the aid of the cobalt labeling technique the following termination areas of the vestibulocochlear nerve are found in the frog. The nucleus cochlearis receives fibers from the cochlear primordia, i.e. the amphibian and basilar papillae and the lagena. The terminals form a spherical pericellular feltwork characteristic of auditory fibers. The nucleus saccularis is supplied exclusively by fibers of sacculus origin terminating with a similar kind of auditory characteristic pattern. The nuclei vestibularis lateralis (Deiters), superior, descendens and medialis can be discerned in the vestibular area. They are supplied by fibers from all vestibular receptors including the lagena. The corpus and lobus auricularis of the cerebellum receive an extensive vestibular projection ending in mossy terminals. Vestibular fibers can be traced also to the oliva superior (from the lagena and sacculus only), the reticular formation, the spinal nucleus of the trigeminus, the motor nuclei of nerves V, accessory VI, IX and XII, and to the dorsal column nuclei. It is concluded that the frog possesses the whole complement of the vestibular nuclear complex known in mammals, although some parts are in primordial form. The nucleus saccularis with the auditory type of terminals may represent a prospective nucleus cochlearis ventralis thus complementing the auditory nuclear complex as well. The extensive primary vestibular projections to other brain stem structures may play a role in the various righting and postural reactions.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neuroscience. - 4 : 12 (1979), p. 2061-2071. -
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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