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001-es BibID:	BIBFORM010153
Első szerző:	Harangi Mariann (belgyógyász, endokrinológus)
Cím:	Benefits and difficulties in measuring HDL subfractions and human paraoxonase-1 activity during statin treatment / Harangi Mariann, Seres Ildikó, Harangi János, Paragh György
Dátum:	2009
ISSN:	0920-3206 (Print)
Megjegyzések:	Dyslipidaemia including decreased high density lipoprotein cholesterol concentration is one of several factors that have been implicated in increased cardiovascular risk. Since their introduction in the 1980s, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have emerged as the one of the best-selling class of medications to date, with numerous trials demonstrating powerful efficacy in preventing cardiovascular diseases. Although statins have been shown to modestly raise or not alter HDL-cholesterol, their effect on HDL subfractions and on HDL-associated enzymes including human paraoxonase- 1 (PON1) has not yet been fully explored. This review summarizes the currently availabe data on the effect of statins on HDL subfractions and on PON1 activity with a particular emphasis on the clinical relevance of these effects. Moreover, methodological problems of HDL subfraction and PON1 activity determinations are also discussed.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Cardiovascular Drugs and Therapy. - 23 : 6 (2009), p. 501-510. -
További szerzők:	Seres Ildikó (1954-) (biokémikus) Harangi János (1950-) (biokémikus, kromatográfus) Paragh György (1953-) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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