Találati lista | Tudóstér

001-es BibID:	BIBFORM017766
Első szerző:	Mezősi Emese
Cím:	Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes / E. Mezosi, J. Szabo, E. V. Nagy, A. Borbely, E. Varga, Gy. Paragh, Z. Varga
Dátum:	2005
ISSN:	0022-0795
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Endocrinology. - 185 : 1 (2005), p. 121-129. -
További szerzők:	Szabó Jenő (belgyógyász, endocrinologus) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Borbély A. Varga Éva Paragh György (1953-) (belgyógyász) Varga Zsuzsa (1951-) (biokémikus, nephrológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM073568
Első szerző:	Somodi Sándor (belgyógyász)
Cím:	Plasminogen activator inhibitor-1 level correlates with lipoprotein subfractions in obese non-diabetic subjects / Sándor Somodi, Ildikó Seres, Hajnalka Lőrincz, Mariann Harangi, Péter Fülöp, György Paragh
Dátum:	2018
Megjegyzések:	Background. The elevated level of plasminogen activator inhibitor-1 (PAI-1) in obese subjects with metabolic syndrome and in patients with type 2 diabetes is well established. Association of plasma PAI-1 and lipid metabolism is still unclear. The aim of the present study was to determine the relationship between plasma PAI-1 levels and the distribution of lipoprotein subfractions in obese and lean non-diabetic individuals. Subjects and Methods. We enrolled fifty non-diabetic obese patients and thirty-two healthy volunteers. Lipoprotein subfractions were detected with Lipoprint System. Plasma PAI-1, tumor necrosis factor-? (TNF-?), interleukin-6 (IL-6) and myeloperoxidase (MPO) concentrations were determined with enzyme-linked immunosorbent assay (ELISA), while serum paraoxonase-1 (PON1) activities were measured by spectrophotometry.Results. The TNF-?, IL-6, oxidized low-density-lipoprotein (oxLDL) and MPO levels were found to be significantly higher, while PON1 paraoxonase and arylesterase activities were non-significantly lower in the obese patients. Strong significant negative correlations were found between plasma PAI-1 concentration and mean LDL-size; as well as between PAI-1 concentrations and the levels of the large and intermediate high-density-lipoprotein (HDL) subfractions. In multiple regression analysis, PAI-1 was predicted by waist circumference and intermediate HDL subfraction. Conclusion. The significant correlations between PAI-1 levels and lipoprotein subfractions indicate the link between PAI-1 and lipid metabolism in obesity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban PAI-1 obesity HDL subfractions
Megjelenés:	International Journal of Endocrinology. - 2018 (2018), p. 1-9. -
További szerzők:	Seres Ildikó (1954-) (biokémikus) Lőrincz Hajnalka (1986-) (biológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Fülöp Péter (1974-) (belgyógyász, endokrinológus, lipidológus) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:	OTKA-115723 OTKA GINOP-2.3.2-15-2016-00005 GINOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM017431
Első szerző:	Szabó Jenő (belgyógyász, endocrinologus)
Cím:	Heterogeneous signal pathways through TSH receptors in porcine thyroid cells following stimulation with Graves' immunoglobulin G. / Szabó J., Fóris G., Keresztes T., Csabina S., Varga Zs., Bakó Gy., Mezősi E., Nagy E., Paragh Gy., Leövey A.
Dátum:	1998
Megjegyzések:	We compared different signal transduction pathways through thyroid stimulating hormone receptor (TSH-R) in porcine thyroid cells (PTC) following stimulation with thyroid stimulating hormone (TSH) and 11 thyroid stimulating immunoglobulin samples (TSI) obtained from patients with Graves' disease. DESIGN: Following stimulation with TSI, the level of inositol trisphosphate (IP3) and [Ca2+]i, as well as the membrane bound protein kinase C (PKC) activity and the intensity of the arachidonic acid (AA) cascade, were determined in PTC. RESULTS: Seven out of eleven TSI samples activated PTC through IP3 generation, elevated [Ca2+]i from the intracellular pools, exhibited verapamil-insensitive membrane-bound PKC activation, and enhanced release of [14C]AA derivates (however, one of the samples was also able to take up Ca2+ from the extracellular space). Four out of eleven TSI samples did not activate the phospholipase C (PLC) system in which case the Ca2+ signal occurred only in the presence of extracellular Ca2+, the membrane bound PKC activation was verapamil sensitive, and in two of these four TSI samples, the AA release was extremely high. CONCLUSIONS: The simultaneous examination of the majority of the known signal pathways using TSI samples showed that TSI samples from different patients activate thyroid cells through different pathways. Their effects differ from that of TSH and, to a certain extent, from each other. The results give a certain new insight into the intracellular mechanisms exerted by TSI.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	European Journal of Endocrinology. - 139 : 3 (1998), p. 355-358. -
További szerzők:	Fóris Gabriella (1937-) (belgyógyász) Keresztes Tamás Csabina Sándor Varga Zsuzsa (1951-) (biokémikus, nephrológus) Bakó Gyula (1951-) (belgyógyász) Mezősi Emese Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász) Leövey András (1926-) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: