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001-es BibID:	BIBFORM116102
035-os BibID:	(Scopus)85164401622 (WOS)001017815400001
Első szerző:	Banach, Maciej
Cím:	Regional differences in physicians' behavior and factors influencing the intensity of PCSK9 inhibitor therapy with alirocumab : a subanalysis of the ODYSSEY APPRISE study / Banach Maciej, Lewek Joanna, Pol Kaja, Rabczenko Daniel, Balanescu Serban M., Blaha Vladimir, Ceska Richard, Jankowski Piotr, Surma Stanisaw, Kolovou Genovefa, Liberopoulos Evangelos, Mitu Florin, Mitu Magda, Naji Franjo Husam, Paragh Gyorgy, Popawska Magdalena, Vrablik Michal, Pella Daniel
Dátum:	2023
ISSN:	2297-055X
Megjegyzések:	BackgroundDespite better accessibility of the effective lipid-lowering therapies, only about 20% of patients at very high cardiovascular risk achieve the low-density lipoprotein cholesterol (LDL-C) goals. There is a large disparity between European countries with worse results observed for the Central and Eastern Europe (CEE) patients. One of the main reasons for this ineffectiveness is therapeutic inertia related to the limited access to appropriate therapy and suitable dosage intensity. Thus, we aimed to compare the differences in physicians' therapeutic decisions on alirocumab dose selection, and factors affecting these in CEE countries vs. other countries included in the ODYSSEY APPRISE study.MethodsODYSSEY APPRISE was a prospective, single-arm, phase 3b open-label (& GE;12 weeks to & LE;30 months) study with alirocumab. Patients received 75 or 150 mg of alirocumab every 2 weeks, with dose adjustment during the study based on physician's judgment. The CEE group in the study included Czechia, Greece, Hungary, Poland, Romania, Slovakia, and Slovenia, which we compared with the other nine European countries (Austria, Belgium, Denmark, Finland, France, Germany, Italy, Spain, and Switzerland) plus Canada.ResultsA total of 921 patients on alirocumab were involved [modified intention-to-treat (mITT) analysis], including 114 (12.4%) subjects from CEE countries. Therapy in CEE vs. other countries was numerically more frequently started with lower alirocumab dose (75 mg) at the first visit (74.6 vs. 68%, p = 0.16). Since week 36, the higher dose was predominantly used in CEE patients (150 mg dose in 51.6% patients), which was maintained by the end of the study. Altogether, alirocumab dose was significantly more often increased by CEE physicians (54.1 vs. 39.9%, p = 0.013). Therefore, more patients achieved LDL-C goal at the end of the study (<55 mg/dl/1.4 mmol/L and 50% reduction of LDL-C: 32.5% vs. 28.8%). The only factor significantly influencing the decision on dose of alirocumab was LDL-C level for both countries' groups (CEE: 199.2 vs. 175.3 mg/dl; p = 0.019; other: 205.9 vs. 171.6 mg/dl; p < 0.001, for 150 and 75 mg of alirocumab, respectively) which was also confirmed in multivariable analysis (OR = 1.10; 95% CI: 1.07-1.13).ConclusionsDespite larger unmet needs and regional disparities in LDL-C targets achievement in CEE countries, more physicians in this region tend to use the higher dose of alirocumab, they are more prone to increase the dose, which is associated with a higher proportion of patients reaching LDL-C goals. The only factor that significantly influences decision whether to increase or decrease the dose of alirocumab is LDL-C level.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Cardiovascular Medicine. - 10 (2023), p. 1-9. -
További szerzők:	Lewek, Joanna Pol, Kaja Rabczenko, Daniel Balanescu, Serban M. Blaha, Vladimir Ceska, Richard Jankowski, Piotr Surma, Stanisaw Kolovou, Genovefa Liberopoulos, Evangelos Mitu, Florin Mitu, Magda Naji, Franjo Husam Paragh György (1953-) (belgyógyász) Popawska, Magdalena Vrablík, Michal Pella, Daniel
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001-es BibID:	BIBFORM083294
Első szerző:	Banach, Maciej
Cím:	The role of red yeast rice (RYR) supplementation in plasma cholesterol control : a review and expert opinion / Maciej Banach, Eric Bruckert, Olivier S. Descamps, Lars Ellegård, Marat Ezhov, Bernhard Foger, Zlatko Fras, Petri T. Kovanen, Gustavs Latkovskis, Winfried Marz, Demosthenes B. Panagiotakos, Gyorgy Paragh, Daniel Pella, Angela Pirillo, Andrea Poli, Zeljko Reiner, Günter Silbernagel, Margus Viigimaa, Michal Vrablík, Alberico L. Catapano
Dátum:	2019
ISSN:	1567-5688
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Atherosclerosis Supplements. - 39 (2019), p. e1-e8. -
További szerzők:	Bruckert, Eric Descamps, Olivier Ellegård, Lars Ezhov, Marat V. Föger, Bernhard Fras, Zlatko Kovanen, Petri T. Latkovskis, Gustavs März, Winfried Panagiotakos, Demosthenes B. Paragh György (1953-) (belgyógyász) Pella, Daniel Pirillo, Angela Poli, Andrea Reiner, Željko Silbernagel, Günter Viigimaa, Margus Vrablík, Michal Catapano, Alberico L.
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001-es BibID:	BIBFORM074202
035-os BibID:	(WoS)000436432000012 (Scopus)85048895824
Első szerző:	Banach, Maciej
Cím:	The role of nutraceuticals in statin intolerant patients / Maciej Banach, Angelo Maria Patti, Rosaria Vincenza Giglio, Arrigo F. G. Cicero, Atanas G. Atanasov, Gani Bajraktari, Eric Bruckert, Olivier Descamps, Dragan M. Djuric, Marat Ezhov, Zlatko Fras, Stephan von Haehling, Niki Katsiki, Michel Langlois, Gustavs Latkovskis, G. B. John Mancini, Dimitri P. Mikhailidis, Olena Mitchenko, Patrick M. Moriarty, Paul Muntner, Dragana Nikolic, Demosthenes B. Panagiotakos, György Paragh, Bernhard Paulweber, Daniel Pella, Christos Pitsavos, Zeljko Reiner, Giuseppe M. C. Rosano, Robert S. Rosenson, Jacek Rysz, Amirhossein Sahebkar, Maria-Corina Serban, Dragos Vinereanu, Michal Vrablik, Gerald F. Watts, Nathan D. Wong, Manfredi Rizzo, International Lipid Expert Panel (ILEP)
Dátum:	2018
ISSN:	0735-1097
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of The American College Of Cardiology. - 72 : 1 (2018), p. 96-118. -
További szerzők:	Patti, Angelo Maria Giglio, Rosaria Vincenza Cicero, Arrigo F. G. Atanasov, Atanas G. Bajraktari, Gani Bruckert, Eric Descamps, Olivier Djuric, Dragan M. Ezhov, Marat V. Fras, Zlatko von Haehling, Stephan Katsiki, Niki Langlois, Michel Latkovskis, Gustavs Mancini, G. B. John Mikhailidis, Dimitri P. Mitchenko, Olena Moriarty, Patrick M. Muntner, Paul Nikolic, Dragana Panagiotakos, Demosthenes B. Paragh György (1953-) (belgyógyász) Paulweber, Bernhard Pella, Daniel Pitsavos, Christos Reiner, Željko Rosano, Giuseppe M. C. Rosenson, Robert S. Rysz, Jacek Sahebkar, Amirhossein Serban, Maria-Corina Vinereanu, Dragos Vrablík, Michal Watts, Gerald F. Wong, Nathan D. Rizzo, Manfredi International Lipid Expert Panel (ILEP)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:

BIBFORM070927

Első szerző:

Cicero, Arrigo F. G.

Cím:

Lipid lowering nutraceuticals in clinical practice : position paper from an International Lipid Expert Panel / Cicero Arrigo F. G., Colletti Alessandro, Bajraktari Gani, Descamps Olivier, Djuric Dragan M., Ezhov V. Marat, Fras Zlatko, Katsiki Niki, Langlois Michel, Latkovskis Gustavs, Panagiotakos Demosthenes B., Paragh Gyorgy, Mikhailidis Dimitri P., Mitchenko Olena, Paulweber Bernhard, Pella Daniel, Pitsavos Christos, Reiner Željko, Ray Kausik K., Rizzo Manfredi, Sahebkar Amirhossein, Serban Maria-Corina, Sperling Laurence S., Toth Peter P., Vinereanu Dragos, Vrablík Michal, Wong Nathan D., Banach Maciej, The International Lipid Expert Panel (ILEP)

Dátum:

2017

ISSN:

1734-1922

Megjegyzések:

Cicero, Arrigo F. G.: Lipid-lowering nutraceuticals in clinical practice : position paper from an International Lipid Expert Panel

Tárgyszavak:

Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban

Megjelenés:

Archives of Medical Science. - 13 : 5 (2017), p. 965-1005. -

További szerzők:

Colletti, Alessandro Bajraktari, Gani Descamps, Olivier Djuric, Dragan M. Ezhov, Marat V. Fras, Zlatko Katsiki, Niki Langlois, Michel Latkovskis, Gustavs Panagiotakos, Demosthenes B. Paragh György (1953-) (belgyógyász) Mikhailidis, Dimitri P. Mitchenko, Olena Paulweber, Bernhard Pella, Daniel Pitsavos, Christos Reiner, Željko Ray, Kausik K. Rizzo, Manfredi Sahebkar, Amirhossein Serban, Maria-Corina Sperling, Laurence S. Tóth Péter P. Vinereanu, Dragos Vrablík, Michal Wong, Nathan D. Banach, Maciej The International Lipid Expert Panel (ILEP)

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Intézményi repozitóriumban (DEA) tárolt változat

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001-es BibID:

BIBFORM070926

Első szerző:

Cicero, Arrigo F. G.

Cím:

Lipid-lowering nutraceuticals in clinical practice : position paper from an International Lipid Expert Panel / Arrigo F. G. Cicero, Alessandro Colletti, Gani Bajraktari, Olivier Descamps, Dragan M. Djuric, Marat Ezhov, Zlatko Fras, Niki Katsiki, Michel Langlois, Gustavs Latkovskis, Demosthenes B. Panagiotakos, Gyorgy Paragh, Dimitri P. Mikhailidis, Olena Mitchenko, Bernhard Paulweber, Daniel Pella, Christos Pitsavos, Željko Reiner, Kausik K. Ray, Manfredi Rizzo, Amirhossein Sahebkar, Maria-Corina Serban, Laurence S. Sperling, Peter P. Toth, Dragos Vinereanu, Michal Vrablík, Nathan D. Wong, Maciej Banach, the International Lipid Expert Panel (ILEP)

Dátum:

2017

Megjelenés:

Utánközlés / Másodközlés

ISSN:

0029-6643

Megjegyzések:

Cicero, Arrigo F. G.: Lipid lowering nutraceuticals in clinical practice : position paper from an International Lipid Expert Panel

Tárgyszavak:

Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban

Megjelenés:

Nutrition Reviews. - 75 : 9 (2017), p. 731-767. -