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001-es BibID:BIBFORM040842
Első szerző:Bodnár Zsolt (sebész)
Cím:Increased serum adenosine and interleukin 10 levels as new laboratory markers of increased intra-abdominal pressure / Zsolt Bodnár, Tamás Keresztes, Ildikó Kovács, Zoltán Hajdu, Gilbert A. Boissonneault, Sándor Sipka
Dátum:2010
ISSN:1435-2443
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Langenbecks Archives of Surgery. - 395 : 7 (2010), p. 969-972. -
További szerzők:Keresztes Tamás Kovács Ildikó Hajdú Zoltán (sebész) Boissonneault, Gilbert A. Sipka Sándor (1945-) (laboratóriumi szakorvos)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:BIBFORM028788
Első szerző:Bodnár Zsolt (sebész)
Cím:Beneficial effects of theophylline infusions in surgical patients with intra-abdominal hypertension / Zsolt Bodnár, Zoltán Szentkereszty, Zoltán Hajdu, Gilbert A. Boissonneault, Sándor Sipka
Dátum:2011
ISSN:1435-2443
Megjegyzések:Background Intra-abdominal hypertension (IAH) can cause high mortality. Recently, we found that IAH was associated with increased serum levels of adenosine and interleukin 10. Our present "hypothesis-generated study" was based on the abovementioned results.Materials and methods In this uncontrolled clinical trial, a total of 78 patients with IAH were enrolled representing a 13?20 mmHg range of intra-abdominal pressure (IAP). Patients requiring surgical abdominal decompression were excluded. Patients were treated with the following protocols: standard supportive therapy (ST, n?=?38) or ST plus infusion with the adenosine receptor antagonist theophylline (T, n?=?40). Over the 5-day measurement period, IAP was monitored continuously and serum adenosine concentration and other clinical and laboratory measurements were monitored daily. Mortality was followed for the first 30 days following the diagnosis of IAH.Results Mortality of ST patients was 55%, which is compatible to other studies. Serum adenosine concentration was found to be directly proportional to IAP. Of the 40 patients receiving T treatment, survival was 100%. An increased survival related to theophylline infusion correlated with improving serum concentrations of IL-10, urea, and creatinine, as well as 24-h urine output, fluid balance, mean arterial pressure, and O2Sat.Conclusions Adenosine receptor antagonism with T following IAH diagnosis resulted in markedly reduced mortality in patients with moderated IAH (<20 mmHg). Theophylline-associated mortality reduction may be related to improved renal perfusion and improved MAP, presumably caused by adenosine receptor blockade. Because this study was not a randomized controlled study, these compelling observations require further multicentric clinical confirmation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Abdominal compartment syndrome (ACS)
Intra-abdominal pressure (IAP)
Intra-abdominal hypertension (IAH)
Adenosine
Theophylline
Megjelenés:Langenbecks Archives of Surgery. - 396 : 6 (2011), p. 793-800. -
További szerzők:Szentkereszty Zoltán Hajdú Zoltán (sebész) Boissonneault, Gilbert A. Sipka Sándor (1945-) (laboratóriumi szakorvos)
Pályázati támogatás:71883
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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