CCL

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001-es BibID:BIBFORM048802
035-os BibID:PMID:24163303
Első szerző:Hunyadi János (bőrgyógyász, kozmetológus, allergológus)
Cím:Autologous Dendritic Cell Based Adoptive Immunotherapy of Patients with Colorectal Cancer : a phase I-II study / János Hunyadi, Csilla András, Imre Szabó, János Szántó, Kornélia Szluha, Sándor Sipka, Péter Kovács, Attila Kiss, Gyula Szegedi, István Altorjay, Péter Sápy, Péter Antal-Szalmás, László Tóth, György Fazekas, Éva Rajnavölgyi
Dátum:2014
ISSN:1219-4956 1532-2807
Megjegyzések:Dendritic cell-based active immunotherapies of cancer patients are aimed to provoke the proliferation and differentiation of tumor-specific CD4+ and CD8+ T-lymphocytes towards protective effector cells. Isolation and in vitro differentiation of circulating blood monocytes has been established a reasonable platform for adoptively transferred DC-based immunotherapies. In the present study the safety and tolerability of vaccination by autologous tumor cell lysates (oncolysate)- or carcinoembriogenic antigen (CEA)-loaded DCs in patients with colorectal cancer was investigated in a phase I-II trial. The study included 12 patients with histologically confirmed colorectal cancer (Dukes B2-C stages). Six of the patients received oncolysate-pulsed, whereas the other six received recombinant CEA-loaded autologous DCs. The potential of the tumor antigen-loaded DCs to provoke the patient's immune system was studied both in vivo and in vitro. The clinical outcome of the therapy evaluated after 7 years revealed that none of the six patients treated with oncolysate-loaded DCs showed relapse of colorectal cancer, whereas three out of the six patients treated with CEA-loaded DCs died because of tumor relapse. Immunization with both the oncolysate- and the CEA-loaded autologous DCs induced measurable immune responses, which could be detected in vivo by cutaneous reactions and in vitro by lymphocyte proliferation assay. Our results show that vaccination by autologous DCs loaded with autologous oncolysates containing various tumor antigens represents a well tolerated therapeutic modality in patients with colorectal cancer without any detectable adverse effects. Demonstration of the efficacy of such therapy needs further studies with increased number of patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Pathology & Oncology Research. - 20 : 2 (2014), p. 357-365. -
További szerzők:András Csilla (1961-) (onkológus szakorvos) Szabó Imre Szántó János (1949-) (onkológus szakorvos) Szluha Kornélia (1955-) (radioterapeuta, radiológus, szülész-nőgyógyász, onkológus) Sipka Sándor (1945-) (laboratóriumi szakorvos) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Kiss Attila (1942-) (belgyógyász, haematológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) Sápy Péter (1942-) (sebész) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Tóth László (1971-) (patológus) Fazekas György Rajnavölgyi Éva (1950-) (immunológus)
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2.

001-es BibID:BIBFORM077078
035-os BibID:(Scopus)85061030845 (WOS)000463785500042
Első szerző:Sipka Sándor (laboratóriumi szakorvos)
Cím:Season Dependent Changes in the Expression of Protein Kinase C Isoenzymes in a Female Patient with Systemic Lupus Erythematosus / Sándor Sipka, Boglárka Brugós, Gabriella Czifra, Zoltán Griger, Norbert Balogh, Tünde Tarr, Gábor Papp, Tamás Bíró, Margit Zeher
Dátum:2019
ISSN:1219-4956 1532-2807
Megjegyzések:We aimed to answer the question whether the decreased expression of protein kinase C (PKC) isoenzymes in the peripheral blood mononuclear cells (PBMC) of patients with systemic lupus erythematosus (SLE) is inherited or not. For this reason we examined the expression of PKC isoenzymes in a European white girl with acute SLE and in her healthy mother and father simultaneously in summer and winter during one year using western blotting and densitometry. We found that in the father the expression of PKC isoenzymes did not differ from that of eight healthy controls included women and men. However, in the SLE-free mother and in the patient arrived in July with acute symptoms of lupus, the expression of PKC isoenzymes showed a season dependent undulation in parallel. Namely, in summer the expression values were significantly lower, in winter they were significantly higher than those in the controls. Thus, the decreased expression of PKC isoenzymes in the PBMC of SLE patient is not a disease specific marker; it appears also in her lupus free mother. This phenomenon may be due to a season dependent female genetic background. However, the low PKC levels in summer can still decrease further the low production of IL-2 in T cells of lupus patients augmenting the existing AP-1 defects. This is the first report on the season and female dependent inherited changing of PKC expression in a European white patient with SLE and her mother. Further studies are needed to confirm these findings in other populations.
European white women
Peripheral blood mononuclear cells (PBMC)
Protein kinase C (PKC)
Season dependence
Systemic lupus erythematosus (SLE)
Tárgyszavak:idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pathology oncology research. - 25 : 2 (2019), p. 801-805. -
További szerzők:Brúgós Boglárka (1975-) (belgyógyász) Czifra Gabriella (1975-) (élettanász) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Balogh Norbert (1988-) (molekuláris biológus) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus) Papp Gábor (1984-) (belgyógyász) Bíró Tamás (1968-) (élettanász) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
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3.

001-es BibID:BIBFORM040843
Első szerző:Várkonyi Judit
Cím:Short or long survival in multiple myeloma : a simple method for determining the prognosis / Várkonyi Judit, Bajzik Edina, Fazakas Ádám, Sipka Sándor, Karádi István
Dátum:2009
ISSN:1219-4956
Megjegyzések:Finding prognostic factors in multiple myeloma is a real challenge. Several attempts might be found in the literature for that purpose but the results are not satisfactory. Therefore, in the current retorpective study authors analyzed the potential prognostic value of some laboratory data in 104 patients with multiple myeloma. They found the albumin and M-component ratio being lower than 1 and the initial WBC <4,5 x 10(9)/l correlated strongly with poor prognosis. In addition the low albumin level was not related to albuminuria and that the low WBC was not linked to bone marrow infiltration rate or to antineutrophil antibody formation. On the basis of their experiences authors created an AMWBC score containing A/M and WBC at diagnosis found to be in good correlation to prognosis. Further studies involving more patients are needed to verify the real prognostic value of AMWBC score in multiple myeloma treated with new targeted therapies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Pathology & Oncology Research. - 15 : 3 (2009), p. 383-387. -
További szerzők:Bajzik Edina Fazakas Ádám Sipka Sándor (1945-) (laboratóriumi szakorvos) Karádi István (1952-) (belgyógyász, kardiológus)
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4.

001-es BibID:BIBFORM028786
Első szerző:Váróczy László (belgyógyász, haematológus)
Cím:Fc-gamma-receptor IIIa polymorphism and gene expression profile do not predict the prognosis in diffuse large B-cell lymphoma treated with R-CHOP protocol / László Váróczy, Erika Zilahi, Ágnes Gyetvai, Béla Kajtár, Lajos Gergely, Sándor Sipka, Árpád Illés
Dátum:2012
ISSN:1219-4956
Megjegyzések:The addition of rituximab to conventional chemotherapy has significantly improved the treatment outcome in diffuse large B-cell lymphoma. However, differences in treatment response and survival data can be observed independently from the International Prognostic Index scores. The current study evaluated the impact of Fc-gamma-receptor IIIa polymorphism and gene expression profile on the response of DLBCL patients to R-CHOP therapy as well as on their survival results. Fifty-one patients were involved, thirty-two females, nineteen males, their median age was 53.1 years. The FCGR3A polymorphism at the 158. amino acid position determined with PCR method showed the following results: VV: 12 cases (23.5%), VF: 29 cases (56.8%) and FF: 10 cases (19.6%), respectively. There was no significant difference between the treatment responses of the three groups. The event-free survival data were less favorable in the F-allele carriers than in V/V homozygous patients, but without any significancy, and the overall survival curves were almost the same. As for the gene expression profile, 20 patients' biopsy specimens showed germinal center and 31 showed non-germinal center characteristics. Treatment results did not differ from each other in the two groups. Both the event-free and the overall survival data were more favorable in the GC group, however the differences were not significant. Our results contest the predictive value of Fc-gamma-receptor IIIa polymorphism and gene expression profile in diffuse large B-cell lymphoma.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Diffuse large B-cell lymphoma
Rituximab
Fc-gamma-receptor IIIa polymorphism
Gene expression profile
Treatment response
Survival
egyetemen (Magyarországon) készült közlemény
Megjelenés:Pathology and Oncology Research 18 : 1 (2012), p. 43-48. -
További szerzők:Zilahi Erika (1964-) (molekuláris biológus) Gyetvai Ágnes Kajtár Béla (1977-) (patológus) Gergely Lajos (1965-) (belgyógyász, haematológus) Sipka Sándor (1945-) (laboratóriumi szakorvos) Illés Árpád (1959-) (belgyógyász, haematológus, onkológus)
Pályázati támogatás:MECANTURA
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