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001-es BibID:	BIBFORM118924
035-os BibID:	(cikkazonosító)1581 (Scopus)85184721995 (WoS)001161185700001
Első szerző:	Bácsi Attila (immunológus)
Cím:	Radiation-Detoxified Form of Endotoxin Effectively Activates Th1 Responses and Attenuates Ragweed-Induced Th2-Type Airway Inflammation in Mice / Attila Bácsi, Beatrix Ágics, Kitti Pázmándi, Béla Kocsis, Viktor Sándor, Lóránd Bertók, Géza Bruckner, Sándor Sipka
Dátum:	2024
ISSN:	1422-0067
Megjegyzések:	Urbanization with reduced microbial exposure is associated with an increased burden of asthma and atopic symptoms. Conversely, environmental exposure to endotoxins in childhood can protect against the development of allergies. Our study aimed to investigate whether the renaturation of the indoor environment with aerosolized radiation-detoxified lipopolysaccharide (RD-LPS) has a preventative effect against the development of ragweed-induced Th2-type airway inflammation. To explore this, cages of six-week-old BALB/c mice were treated daily with aerosolized native LPS (N-LPS) or RD-LPS. After a 10-week treatment period, mice were sensitized and challenged with ragweed pollen extract, and inflammatory cell infiltration into the airways was observed. As dendritic cells (DCs) play a crucial role in the polarization of T-cell responses, in our in vitro experiments, the effects of N-LPS and RD-LPS were compared on human monocyte-derived DCs (moDCs). Mice in RD-LPS-rich milieu developed significantly less allergic airway inflammation than mice in N-LPS-rich or common environments. The results of our in vitro experiments demonstrate that RD-LPS-exposed moDCs have a higher Th1-polarizing capacity than moDCs exposed to N-LPS. Consequently, we suppose that the aerosolized, non-toxic RD-LPS applied in early life for the renaturation of urban indoors may be suitable for the prevention of Th2-mediated allergies in childhood.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk endotoxin lipopolysaccharide radiation-detoxified Th2-type airway inflammation allergy dendritic cells ragweed mice
Megjelenés:	International Journal Of Molecular Sciences. - 25 : 3 (2024), p. 1-22. -
További szerzők:	Ágics Beatrix (1995-) Pázmándi Kitti Linda (1984-) (molekuláris biológus, immunológus) Kocsis Béla Sándor Viktor Bertók Lóránd (1934-) (sugárbiológus, immunológus) Bruckner Géza Sipka Sándor (1945-) (laboratóriumi szakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM076593
Első szerző:	Sipka Sándor (laboratóriumi szakorvos)
Cím:	Comparison of endotoxin levels in cow's milk samples derived from farms and shops / Sipka Sándor, Béres Andrea, Bertók Lóránd, Varga Tamara, Bruckner Geza
Dátum:	2015
ISSN:	1753-4259 1753-4267
Megjegyzések:	The observations on the protective effect of bacterial endotoxin in farm-derived cow's milk on childhood asthma and allergy are contradictory. The aim of this study was to determine the endotoxin levels in ♭farm-derived whole raw' and ♭processed shop' sources of cow's milk, and to test how the temperature and storing conditions might alter their endotoxin concentrations. Milk was collected from farms and shops. The level of endotoxin was measured by micro (gel-clot) Limulus amebocyte lysate test expressed as EU/ml. The concentration ranges of endotoxin were much higher and more widely scattered in the samples of whole raw farm milk than in the processed shop milk. Cold storage or heating increased the endotoxin concentrations in all samples of farm milk, but not in the processed shop milk. These results show that elevated levels of endotoxin in raw farm milk samples can occur from the cowshed or be formed during storage. In processed shop milk, storage does not cause any changes in the amount of endotoxin. Therefore, it is consistent that the handling and storage of raw milk alters the endotoxin concentrations, which may explain previous contradictory findings regarding the beneficial modulating effects on innate immunity toward allergy prevention in early childhood.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Allergy prevention cow's milk endotoxin temperature dependence
Megjelenés:	Innate Immunity. - 21 : 5 (2015), p. 531-536. -
További szerzők:	Béres Andrea Bertók Lóránd (1934-) (sugárbiológus, immunológus) Varga Tamara Bruckner Géza
Pályázati támogatás:	71883 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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