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001-es BibID:	BIBFORM007050
Első szerző:	Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:	Five-year follow-up of 665 Hungarian patients with undifferentiated connective tissue disease (UCTD) / Bodolay, E., Csiki, Z., Szekanecz, Z., Ben, T., Kiss, E., Zeher, M., Szucs, G., Danko, K., Szegedi, G.
Dátum:	2003
ISSN:	0392-856X (Print)
Megjegyzések:	To determine the clinical symptoms and the panel of autoantibodies of patients with early undifferentiated connective tissue disease (UCTD) followed for at least 1 year. METHODS: 716 UCTD patients with manifestations suggestive but not diagnostic of specific connective tissue disease (CTD) were recruited and followed up between 1994-1999. The patients with early UCTD were subdivided into those with isolated Raynaud's phenomenon (RP) (50 patients), unexplained polyarthritis (31 patients) and "true" UCTD (665 patients). UCTD was diagnosed on the basis of clinical manifestations suggestive of a connective tissue disease and the presence of at least one non-organ specific autoantibody. The patients' sera were tested for anti-nuclear (ANA), as well as for nine different specific autoantibodies (anti-dsDNA, -Sm, -RNP, -SSA, -SSB, -Scl-70, -centromere, -Jo1 and -PM-Scl). RESULTS: The most common clinical manifestations of UCTD included RP, arthritis/arthralgias, pleuritis/pericarditis, sicca symptoms, cutaneous involvement (photosensitivity, rash), central nervous symptoms, peripheral neuropathy, fever, vasculitis, less pulmonary involvement and myositis. 230 of the 665 true UCTD patients (34.5%) developed a defined CTD (28 systemic lupus erythematosus [SLE], 26 mixed connective tissue disease [MCTD], 19 progressive systemic sclerosis [PSS], 45 Sjogren's syndrome, 3 polymyositis/dermatomyositis [PM/DM], 87 rheumatoid arthritis [RA], and 22 systemic vasculitis. 435 of 665 patients (65.4%) remained in the UCTD state, and 82 of 665 patients (12.3%) achieved complete remission with symptoms not reappearing within the 5-year period. The highest probability of evolution to a defined CTD was during the first 2 years after onset: of 230 UCTD patients 183 (79.5%) developed major organ symptoms and signs. In particular skin and cardiac complications seemed to spread during the follow-up period in those patients who progressed to SLE. The condition of 18/50 patients with isolated RP evolved to UCTD and 3 of 31 patients with unexplained polyarthritis progressed to definite CTD (2 patients RA and one MCTD). CONCLUSION: In our study most of the UCTD patients did not develop a definite CTD, but during the follow-up period we found new clinical and serological manifestations. One-third of the UCTD patients showed progress into different types of specific CTD.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adolescent Adult Aged Autoantibodies Autoimmunity Cohort Studies Confidence Intervals Connective Tissue Diseases Disease Progression Female Follow-Up Studies Humans Hungary Logistic Models Lupus Erythematosus, Systemic Male Middle Aged Polymyositis Probability Prognosis Retrospective Studies Scleroderma, Systemic egyetemen (Magyarországon) készült közlemény Severity of Illness Index Sjogren's Syndrome Time Factors Vasculitis
Megjelenés:	Clinical and Experimental Rheumatology. - 21 : 3 (2003), p. 313-320. -
További szerzők:	Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Ben, Thomas Kiss Emese (1960-) (belgyógyász, immunológus) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
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001-es BibID:	BIBFORM022710
Első szerző:	Galuska László (belgyógyász, izotópdiagnoszta)
Cím:	Fingers-to-palm ratio : a new index of the microcircular abnormalities of the fingers / L. Galuska, I. Garai, Z. Csiki, J. Varga, E. Bodolay, A. Szanyi
Dátum:	1998
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt fingers egyetemen (Magyarországon) készült közlemény
Megjelenés:	European Journal of the Nuclear Medicine. - 25 : 8 (1998), p. 988. -
További szerzők:	Garai Ildikó (1966-) (radiológus) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Varga József (1955-) (fizikus) Bodolay Edit (1950-) (belgyógyász, allergológus és klinikai immunológus) Szanyi Adrienn
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM021460
Első szerző:	Galuska László (belgyógyász, izotópdiagnoszta)
Cím:	The clinical usefulness of the fingers-to-palm ratio in different hand microcirculatory abnormalities / L. Galuska, I. Garai, Z. Csiki, J. Varga, E. Bodolay, L. Bajnok
Dátum:	2000
ISSN:	0143-3636
Megjegyzések:	A non-invasive nuclear medicine technique was developed to screen patients with painful hands so as to separate patients with a normal from those with an abnormal microcirculation of the hands in different clinical conditions. Such a technique is important, as the other methods available are either subjective or rather complicated. The study population consisted of 10 healthy individuals, 23 patients with Raynaud's syndrome and 15 patients with mixed connective tissue disease (MCTD). Sixty gamma-camera images of the hands (1 s each) were recorded after a bolus injection of 99Tcm-DTPA via a dorsal foot vein. Regions of interest were drawn on the summed images around the fingers and the palmar region. The fingers-to-palm ratio was then calculated from the total counts inside these regions of interest separately for each hand. The mean fingers-to-palm ratio was 0.94+/-0.18 (0.71-1.25) for the healthy group, 0.57+/-0.22 (0.21+/-1.11) for the MCTD group and 0.40+/-0.14 (0.18-0.77) for the Raynaud's patients. Analysis of variance showed these differences to be highly significant (P < 0.001). There were also significant differences between 6 MCTD patients in an active (mean 0.48) and nine patients in an inactive (mean 0.66) clinical state (two-sample t-test: P < 0.05). There were no significant differences between the fingers-to-palm ratios of the left and right hands of the same patients (one-sample t-test). Of the 23 primary Raynaud's patients, capillary microscopic data were pathological in only eight (34%). We conclude that our method is able to differentiate between patients with normal and those with abnormal microcirculation of the hands. Although measurement of the fingers-to-palm ratio is not a specific method, it is useful both for staging and in the follow-up of patients.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban the clinical usefulness egyetemen (Magyarországon) készült közlemény
Megjelenés:	Nuclear Medicine Communications. - 21 : 7 (2000), p. 659-663. -
További szerzők:	Garai Ildikó (1966-) (radiológus) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Varga József (1955-) (fizikus) Bodolay Edit (1950-) (belgyógyász, allergológus és klinikai immunológus) Bajnok László (1961-) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM019775
Első szerző:	Galuska László (belgyógyász, izotópdiagnoszta)
Cím:	Az ujj-tenyér keringési hányados radionuklid meghatározása microcirkulációs zavarokban / Galuska László, Garai Ildikó, Csiki Zoltán, Varga József, Bodolay Edit, Bajnok László
Dátum:	1999
Megjegyzések:	A non-invasive nuclear medicine method was developed for screening patients (PTS) with painful hands, in order to separate PTS with normal from those with abnormal microcirculation (MIC) of the hands in different clinical conditions. Such a method would be of great importance as the other methods available are either importance as the other methods available are either subjective or rather complicated. The study comprised ten healthy individuals, twenty-three PTS with Raynaud syndrome (RS), and fifteen PTS with mixed connective tissue disease (MCTD) - 6 active and 9 inactive. After the bolus injection of 99mTc-DTPA through a dorsal foot vein, dynamic study was performed during 1 min. (1 sec/game images). Regions of interest (ROIs) were drawn on the summed images around the fingers, and the palmar region. The fingers-to-palm ratio (FPR) is then calculated from the total counts inside these ROIs separately for each hand. Mean FPR was 0.94+-0.18 (0.71-1.25) for the healthy group, 0.57+-0.22 (0.21-1.11) for the MCTD group, and 0.40+-0.14 (0.18-0.77) for the Raynaud PTS. Variance analysis showed these differences to be highly significant (P<0.001). There were also significant differences between 6 MTCD PTS in active (mean 0.48) and 9 in inactive (mean 0.66) clinical state (2 sample t-test: P<0.05). However, there were no significant differences between the FPR values of left and right hands of the same patient (1 sample t-test). From among the 23 primary Raynaud PTS, capillary microscopic data were pathological in only 8 cases (34 per cent). We conclude that our method is capable for differentiating PTS with normal from those with abnormal MIC of the hands. Though the FPR measurement is not a specific method, it is useful both for staging and in the follow-up of PTS.
Tárgyszavak:	Orvostudományok Egészségtudományok magyar nyelvű folyóiratközlemény hazai lapban ujj-tenyér egyetemen (Magyarországon) készült közlemény
Megjelenés:	Érbetegségek. - 6 : 4 (1999), p. 127-131. -
További szerzők:	Garai Ildikó (1966-) (radiológus) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Varga József (1955-) (fizikus) Bodolay Edit (1950-) (belgyógyász, allergológus és klinikai immunológus) Bajnok László (1961-) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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