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001-es BibID:	BIBFORM044071
035-os BibID:	PMID:23541481
Első szerző:	Osnes, Liv T.
Cím:	Assessment of intracellular cytokines and regulatory cells in patients with autoimmune diseases and primary immunodeficiencies - Novel tool for diagnostics and patient follow-up / Liv T. Osnes, Britt Nakken, Edit Bodolay, Péter Szodoray
Dátum:	2013
ISSN:	1568-9972
Megjegyzések:	Serum and intracytoplasmic cytokines are mandatory in host defense against microbes, but also play a pivotal role in the pathogenesis of autoimmune diseases by initiating and perpetuating various cellular and humoral autoimmune processes. The intricate interplay and fine balance of pro- and anti-inflammatory processes drive, whether inflammation and eventually organ damage will occur, or the inflammatory cascade quenches. In the early and late, as well as inactive and active stages of autoimmune diseases, different cellular and molecular patterns can dominate in these patients. However, the simultaneous assessment of pro- and anti-inflammatory biomarkers aids to define the immunological state of a patient. A group of the most useful inflammatory biomarkers are cytokines, and with increasing knowledge during the last decade their role have been well-defined in patients with autoimmune diseases and immunodeficiencies. Multiple pathological processes drive the development of autoimmunity and immunodeficiencies, most of which involve quantitative and qualitative disturbances in regulatory cells, cytokine synthesis and signaling pathways. The assessment of these biomarkers does not aid only in the mechanistic description of autoimmune diseases and immunodeficiencies, but further helps to subcategorize diseases and to evaluate therapy responses. Here, we provide an overview, how monitoring of cytokines and regulatory cells aid in the diagnosis and follow-up of patients with autoimmune diseases and immunodeficiencies furthermore, we pinpoint novel cellular and molecular diagnostic possibilities in these diseases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban intracellular cytokine autoimmune diseases Immunodeficiencies Regulatory T cells Th17 cells
Megjelenés:	Autoimmunity Reviews 12 : 10 (2013), p. 967-971. -
További szerzők:	Nakken, Britt Bodolay Edit (1950-) (belgyógyász, allergológus és klinikai immunológus) Szodoray Péter (1973-) (belgyógyász, orvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM048758
035-os BibID:	PMID:23974054
Első szerző:	Szodoray Péter (belgyógyász, orvos)
Cím:	Altered Th17 cells and Th17/regulatory T-cell ratios indicate the subsequent conversion from undifferentiated connective tissue disease to definitive systemic autoimmune disorders / Peter Szodoray, Britt Nakken, Sandor Barath, Istvan Csipo, Gabor Nagy, Fadi El-Hage, Liv T. Osnes, Gyula Szegedi, Edit Bodolay
Dátum:	2013
ISSN:	0198-8859
Megjegyzések:	A shift in the balance between Th17-cells and regulatory T-cells (Treg) is an important feature of systemic autoimmune diseases (SAID), and may also contribute to their development. Hereby, we assessed the distribution of peripheral Th17 and Treg-cells in patients with undifferentiated connective tissue disease (UCTD), the forerunner of SAIDs and followed these parameters during the development towards definitive SAIDs. Fifty-one UCTD patients were investigated and followed-up for 3years. Flow cytometry was used to identify and follow three cell-populations: Th17-cells (CD4+IL-17+ T-cells), natural regulatory T-cells (CD4+CD25brightFoxP3+; nTregs) and IL-10 producing Type-1 regulatory T-cells (CD4+IL-10+ T-cells; Tr1). Altogether 37.3% of these patients progressed into SAIDs. Th17-cells were increased in UCTD vs. controls, which further increased in those, whom developed SAIDs eventually. The Th17/nTreg ratio gradually increased from controls through UCTD patients, reaching the highest values in SAID-progressed patients. Regarding the Th17/Tr1 ratios, a similar tendency was observed moreover Th17/Tr1 could distinguish between UCTD patients with, or without subsequent SAID progression in a very early UCTD stage. Various immunoserological markers showed association with Th17 and Th17/nTreg at baseline, indicating the consecutive development of a distinct SAID. The derailed Th17/Treg balance may contribute to disease progression therefore could function as a prognostic marker.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Scleroderma-70 antigen DNA Topoisomerase I C-reactive protein SLE Type-1 regulatory T-cells
Megjelenés:	Human Immunology 74 : 12 (2013), p. 1510-1518. -
További szerzők:	Nakken, Britt Baráth Sándor (1977-) (biológus) Csípő István (1953-) (vegyész) Nagy Gábor (1974-) (laboratóriumi szakorvos, laboratóriumi hematológus és immunológus) El-Hage, Fadi Osnes, Liv T. Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Bodolay Edit (1950-) (belgyógyász, allergológus és klinikai immunológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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