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001-es BibID:	BIBFORM021861
Első szerző:	Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:	Expression of HLA-DR antigens by thyroid cells : the effect of Graves' IgG / Edit Bodolay, Gyula Szegedi, Péter Surányi, Ferenc Juhász, Valéria Stenszky, Csaba Balázs, Nadir R. Farid
Dátum:	1987
Megjegyzések:	We have investigated factors which influence HLA-DR expression on thyroid cells. While bTSH (100 mU/ml) did not enhance HLA-DR expression, it increased when brought about by IFN-gamma. Graves' IgG showed a dose-dependent (0.1-2 mg/ml) increase in DR expression and at a concentration of 2 mg/ml prolonged the time for which DR was expressed. The pathway of DR induction by Graves' IgG apparently differs from that by IFN-gamma. The humoral response in Graves' disease, by inducing DR expression, may be instrumental in propagating thyroid specific autoimmunity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Immunology letters. - 15 : 1 (1987), p. 77-81. -
További szerzők:	Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Surányi Péter Juhász Ferenc Stenszky Valéria Balázs Csaba Farid, Nadir R.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM005999
Első szerző:	Surányi Péter
Cím:	B lymphocyte subsets in Hashimoto's thyroiditis / Peter Suranyi, Gyula Szegedi, Sandor Damjanovich, Ferenc Juhasz, Valeria Stenszky, Nadir R. Farid
Dátum:	1989
Megjegyzések:	Two B lymphocyte subsets are identified on the basis of possession or lack of a surface molecule, CD5. The CD5+ B lymphocytes synthesize autoantibodies and in the process rearrange proximal variables of immunoglobulin genes. We have here studied the proportion and absolute counts of CD5+ B lymphocytes in the peripheral blood of 31 patients with Hashimoto's thyroiditis and related the findings to their HLA phenotypes and clinical features. Although the percentage and absolute number of surface immunoglobulin-positive (B) lymphocytes was comparable in patients to those in twenty controls, % CD5+ was significantly higher in the patient group (38.1 +/- 11.6 [+/- S.D.] vs. 27.9 +/- 10.1, p = 0.009). The absolute CD5+ cells (microliters) were also higher in patients with Hashimoto's thyroiditis (77.90 +/- 37.50 vs. 55.1 +/- 29.8, p = 0.020). The proportion of CD5+ cells was even higher in HLA-DR3 positive patients (43.1% +/- 7.2, n = 13) compared to six DR3+ controls (26.17% +/- 9.7, p = 0.0005). The difference between DR3- patients and controls was not significant (28.6% +/- 10.5 vs. 34.4% +/- 13.0). As the CD5 molecule may be induced on activated B lymphocytes, this study suggests that Hashimoto's thyroiditis is associated with an increase of activated B lymphocytes engaged in autoantibody synthesis. This defect is particularly obvious in DR3+ patients.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis Antigens,CD5 Antigens,Differentiation Antigens,Differentiation,B-Lymphocyte Autoantibodies B-Lymphocytes blood classification Histocompatibility Antigens Histocompatibility Antigens Class II Human Hungary Immunoglobulins,Surface immunology Lymphocytes pathology Support,Non-U.S.Gov't Thyroiditis,Autoimmune
Megjelenés:	Immunology Letters. - 22 : 2 (1989), p. 147-150. -
További szerzők:	Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Damjanovich Sándor (1936-2017) (biofizikus) Juhász Ferenc Stenszky Valéria Farid, Nadir R.
Internet cím:	elektronikus változat DOI
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