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001-es BibID:BIBFORM090160
035-os BibID:(cikkazonosító)1367 (WOS)000626774100081 (Scopus)85099483306
Első szerző:Hegyi Péter Jr. (belgyógyász)
Cím:Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis : a cross-sectional multicentre international study with experimental animal model / Péter J. Hegyi, Alexandra Soós, Emese Tóth, Attila Ébert, Viktória Venglovecz, Katalin Márta, Péter Mátrai, Alexandra Mikó, Judit Bajor, Patrícia Sarlós, Áron Vincze, Adrienn Halász, Ferenc Izbéki, Zoltán Szepes, László Czakó, György Kovács, Mária Papp, Zsolt Dubravcsik, Márta Varga, József Hamvas, Balázs C. Németh, Melania Macarie, Ali Tüzüm Ince, Elena A. Dubtsova, Mariya A. Kirynkova, Igor E. Khatkov, Tanya Bideeva, Artautas Mickevicius, Elena Ramírez-Maldonado, Ville Sallinen, Bálint Erős, Dániel Pécsi, Andrea Szentesi, Andrea Párniczky, László Tiszlavicz, Péter Hegyi
Dátum:2021
ISSN:2045-2322
Megjegyzések:Abstract Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 11 : 1 (2021), p. 1-14. -
További szerzők:Soós Alexandra Tóth Emese Ébert Attila Venglovecz Viktória Márta Katalin Mátrai Péter Mikó Alexandra Bajor Judit Sarlós Patrícia Vincze Áron Halász Adrienn Izbéki Ferenc Szepes Zoltán Czakó László Kovács György (1982-) (belgyógyász, gasztroenterológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Dubravcsik Zsolt (belgyógyász, gasztroenterológus) Varga Márta Hamvas József Németh Balázs Csaba Macarie, Melania Ince, Ali Tüzün Dubtsova, Elena A. Kirynkova, Mariya A. Khatkov, Igor E. Bideeva, Tanya Mickevicius, Artautas Ramírez-Maldonado, Elena Sallinen, Ville Erős Bálint Pécsi Dániel Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Tiszlavicz László Hegyi Péter Jenő (belgyógyász)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM076218
035-os BibID:(cikkazonosító)1776 (WoS)000463100200001 (Scopus)85068267109
Első szerző:Szakács Zsolt
Cím:Aging and Comorbidities in Acute Pancreatitis II. : a Cohort-analysis of 1203 Prospectively Collected Cases / Zsolt Szakács, Noémi Gede, Dániel Pécsi, Ferenc Izbéki, Mária Papp, György Kovács, Eszter Fehér, Dalma Dobszai, Balázs Kui, Katalin Márta, Klára Kónya, Imre Szabó, Imola Török, László Gajdán, Tamás Takács, Patrícia Sarlós, Szilárd Gódi, Márta Varga, József Hamvas, Áron Vincze, Andrea Szentesi, Andrea Párniczky, Peter Hegyi
Dátum:2019
Megjegyzések:Introduction: Our meta-analysis indicated that aging influences the outcomes of acute pancreatitis (AP), however, a potential role for comorbidities was implicated, as well. Here we aimed to determine how age and comorbidities modify the outcomes in AP in a cohort-analysis of Hungarian AP cases. Materials and methods: Data of patients diagnosed with AP by the revised Atlanta criteria were extracted from the Hungarian National Pancreas Registry. Outcomes of interest were mortality, severity, length of hospitalization, local, and systemic complications of AP. Comorbidities were measured by means of Charlson Comorbidity Index (CCI) covering pre-existing chronic conditions. Non-parametric univariate and multivariate statistics were used in statistical analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Results: A total of 1203 patients from 18 centers were included. Median age at admission was 58 y (range: 18-95 y), median CCI was 2 (range: 0-10). Only severe comorbidities (CCI?3) predicted mortality (OR=4.48; CI: 1.57-12.80). Although severe comorbidities predicted AP severity (OR=2.10, CI: 1.08-4.09), middle (35-64 years) and old age (?65 years) were strong predictors with borderline significance, as well (OR=7.40, CI: 0.99-55.31 and OR=6.92, CI: 0.91-52.70, respectively). Similarly, middle and old age predicted a length of hospitalization ?9 days. Interestingly, the middle-aged (35-64 years) were three times more likely to develop pancreatic necrosis than young adults (OR=3.21, CI: 1.26-8.19), whereas the old-aged (?65 years) were almost nine times more likely to develop systemic complications than young adults (OR=8.93, CI: 1.20-66.80), though having severe comorbidities (CCI?3) was a predisposing factor, as well. Conclusion: Both aging and comorbidities modify the outcomes of AP. Comorbidities seem to be decisive regarding mortality and severity, however, age is a strong predictor of the latter, as well. The middle-aged are the most likely to develop local complications, whereas those having severe comorbidities are vulnerable to developing systemic complications. Studies validating the implementation of CCI-based predictive scores are awaited.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
acute pancreatitis
comorbidities
mortality
severity
length of hospitalization
complications
prediction
Charlson Comorbidity Index
Megjelenés:Frontiers in Physiology. - 2019 (2019). -
További szerzők:Gede Noémi Pécsi Dániel Izbéki Ferenc Papp Mária (1975-) (belgyógyász, gasztroenterológus) Kovács György (1982-) (belgyógyász, gasztroenterológus) Fehér Eszter Dobszai Dalma Kui Balázs Márta Katalin Kónya Klára Szabó Imre Török Imola Gajdán László Takács Tamás (Szeged) Sarlós Patrícia Gódi Szilárd Varga Márta Hamvas József Vincze Áron Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász)
Pályázati támogatás:KH125678
OTKA
K116634
OTKA
K120335
OTKA
GINOP-2.3.2-15-2016-00048
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:
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