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001-es BibID:	BIBFORM117037
035-os BibID:	(cikkazonosító)16203 (WoS)001119803600001 (Scopus)85177758034
Első szerző:	Ilosvai Ágnes Mária
Cím:	Development of Polymer-Encapsulated, Amine-Functionalized Zinc Ferrite Nanoparticles as MRI Contrast Agents / Ágnes M. Ilosvai, LászlóForgách, Noémi Kovács, Fatemeh Heydari, Krisztián Szigeti, Domokos Máthé, Ferenc Kristály, Lajos Daróczi, Zoltán Kaleta, Béla Viskolcz, Miklós Nagy, László Vanyorek
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	The need for stable and well-defined magnetic nanoparticles is constantly increasing in biomedical applications; however, their preparation remains challenging. We used two different solvothermal methods (12 h reflux and a 4 min microwave, MW) to synthesize amine-functionalized zinc ferrite (ZnFe2O4-NH2) superparamagnetic nanoparticles. The morphological features of the two ferrite samples were the same, but the average particle size was slightly larger in the case of MW activation: 47 +/- 14 nm (Refl.) vs. 63 +/- 20 nm (MW). Phase identification measurements confirmed the exclusive presence of zinc ferrite with virtually the same magnetic properties. The Refl. samples had a zeta potential of -23.8 +/- 4.4 mV, in contrast to the +7.6 +/- 6.8 mV measured for the MW sample. To overcome stability problems in the colloidal phase, the ferrite nanoparticles were embedded in polyvinylpyrrolidone and could be easily redispersed in water. Two PVP-coated zinc ferrite samples were administered (1 mg/mL ZnFe2O4) in X BalbC mice and were compared as contrast agents in magnetic resonance imaging (MRI). After determining the r1/r2 ratio, the samples were compared to other commercially available contrast agents. Consistent with other SPION nanoparticles, our sample exhibits a concentrated presence in the hepatic region of the animals, with comparable biodistribution and pharmacokinetics suspected. Moreover, a small dose of 1.3 mg/body weight kg was found to be sufficient for effective imaging. It should also be noted that no toxic side effects were observed, making ZnFe2O4-NH2 advantageous for pharmaceutical formulations.
Tárgyszavak:	Természettudományok Fizikai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk fast microwave synthesis ferrite magnetic nanoparticles MRI zinc
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 22 (2023), p. 1-8. -
További szerzők:	Forgách László Kovács Noémi Heydari, Fatemeh Szigeti Krisztián Máthé Domokos Kristály Ferenc Daróczi Lajos (1965-) (fizikus) Kaleta Zoltán Viskolcz Béla Nagy Miklós Vanyorek László
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