CCL

Összesen 9 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM106493
035-os BibID:(cikkazonosító)1080046 (scopus)85148346981 (wos)000932236400001
Első szerző:Fekete Klára (neurológus)
Cím:Predictors and long-term outcome of intracranial hemorrhage after thrombolytic therapy for acute ischemic stroke : A prospective single center study / Fekete Klára, Héja Máté, Márton Sándor, Tóth Judit, Horváth László, Harman Aletta, Fekete István
Dátum:2023
ISSN:1664-2295
Megjegyzések:Introduction: Acute ischemic stroke (AIS) is a potentially devastating disease with high disability and mortality. Recombinant tissue plasminogen activator (rt-PA) is an effective treatment with a 2-8% possible risk for symptomatic intracranial hemorrhage (sICH). Our aim was to investigate the risk factors and long-term clinical outcome of ICH in patients after rt-PA treatment. Methods: Consecutive patients with AIS, thrombolyzed at the Department of Neurology, University of Debrecen between January 1, 2004 and August 31, 2016 were enrolled prospectively. Risk factors, stroke severity based on the National Institute of Health Stroke Scale (NIHSS), functional outcome using modified Rankin-scale and mortality at one year were compared in patients with and without ICH following rt-PA treatment. We evaluated clinical characteristics and prognosis by hemorrhage type based on the Heidelberg Bleeding Classification. Descriptive statistics, ?2-test, Mann-Whitney U-test, ANOVA and Kruskal-Wallis-test, survival analysis, logistic regression were performed as appropriate. Results: Out of 1252 thrombolyzed patients, ICH developed in 138 patients, 37 (2.95%) being symptomatic. Mean ages in the ICH and non-ICH groups differed significantly (p=0.041). On- admission- and 24-hours-NIHSS after thrombolysis were higher in ICH patients (p<0.0001). Large vessel occlusion was more prevalent in ICH patients (p=0.0095). The ICH risk was lower after intravenous thrombolysis than intra-arterial or combined thrombolysis (p<0.0001). Both at 3 months and at one year the outcome was worse in ICH patients compared to the non-ICH group (p<0.0001). Mortality and poor outcome were more prevalent in all hemorrhage types with a tendency for massive bleeding associated with unfavorable prognosis. At 3 months with logistic regression model worse outcome was detected in patients with ICH after thrombolysis; at one year in patients with ICH after thrombolysis and smoking. Discussion: Older age, higher NIHSS, large vessel occlusion and intra-arterial thrombolysis may correlate with ICH. Unfavorable outcome is more common in ICH patients. Precise scoring of post-thrombolysis bleeding might be a useful tool in the evaluation of the patients' prognosis. Our findings may help to identify predictors and estimate the prognosis of ICH in patients with AIS treated with rt-PA.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Neurology. - 14 (2023), p. 1-11. -
További szerzők:Héja Máté (1991-) (általános orvos) Márton Sándor (1965-) (matematikus) Tóth Judit (1964-) (radiológus) Horváth László (1973-) (gyógyszerész) Harman Aletta (1984-) (orvos) Fekete István (1951-) (neurológus, pszichiáter)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM096522
035-os BibID:(cikkazonosító)757078 (WoS)000717640900001 (Scopus)85118804752
Első szerző:Fekete Klára (neurológus)
Cím:Neurophysiological examinations as adjunctive tool to imaging techniques in spontaneous intracerebral haemorrhage : IRONHEART study / Fekete Klára, Tóth Judit, Horváth László, Márton Sándor, Héja Máté, Csiba László, Árokszállási Tamás, Bagoly Zsuzsa, Sulina Dóra, Fekete István
Dátum:2021
ISSN:1664-2295
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Neurology. - 12 (2021), p. 1-15. -
További szerzők:Tóth Judit (1964-) (radiológus) Horváth László (1973-) (gyógyszerész) Márton Sándor (1965-) (matematikus) Héja Máté (1991-) (általános orvos) Csiba László (1952-) (neurológus, pszichiáter) Árokszállási Tamás (1988-) (neurológus) Bagoly Zsuzsa (1978-) (orvos) Sulina Dóra (PhD hallgató) Fekete István (1951-) (neurológus, pszichiáter)
Pályázati támogatás:K109712
OTKA
K120042
OTKA
FK128582
OTKA
GINOP-2.3.2-15-2016-00043
GINOP
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM099581
035-os BibID:(WoS)000748044100001 (Scopus)85123453367
Első szerző:Girgis, Michael Magdy Fahmy (Gyógyszerész)
Cím:Use of complementary and alternative medicine among patients with epilepsy and diabetes mellitus, focusing on the outcome of treatment / Michael Magdy Fahmy Girgis, Klára Fekete, Nóra Homoródi, Sándor Márton, István Fekete, László Horváth
Dátum:2022
ISSN:1662-453X
Megjegyzések:Introduction Millions all over the world live with epilepsy and they may require long-term drug treatment. The use and interest in complementary and alternative medicine (CAM) have grown over the previous years. Co-administration of herbal products with medicines may result in adverse drug reactions (ADR) and/or unfavourable interactions. The aims of this study were to determine the prevalence of CAM use among patients with epilepsy and, also, to compare the results to those of the patients with diabetes mellitus (DM); to reveal factors that may drive the use of CAM; and to measure outcomes and adherence. It was also our intent to have state-of-art information of CAM use in our region among patients with the two diseases above. Methods We conducted a non-interventional study using a self-developed questionnaire. It was distributed among adult patients with either epilepsy or diabetes mellitus who also suffered from cardiovascular consequences. A database was compiled from the anonymous questionnaires, filled in voluntarily by the patients. Basic statistics were used to analyse this database. Results A total of 227 questionnaires were filled in by 127 patients (55.9%) with epilepsy and 100 patients (44.1%) with diabetes mellitus. Mean age was 54.54?17.33 years. Of the patients, 50.2% were male. Average body weight was 80.3?17.3 kg. Of the patients, 22 (9.7%) used CAM because they believed in CAM. Two of them reported ADR. Among the patients with epilepsy, the ratio was only 7.9% compared to 12% among those with diabetes mellitus. While the number of CAM users was higher among younger patients with epilepsy, it was the elderly patients with diabetes mellitus who tended to use CAM. Conclusion Attention should be paid to reliance on CAM during the follow-up. Our finding that health-conscious patients tend to use CAM more often (than the general population) may indicate it is necessary to discuss CAM usage sincerely. CAMs modulating CYPs enzymes were the most common, leading to interactions with medication used and resulting in ADR. This shows the importance of educating patients and treating team including clinical pharmacist in this field is essential.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Neuroscience. - 15 (2022), p. 1-12. -
További szerzők:Fekete Klára (1978-) (neurológus) Homoródi Nóra (1974-) (kardiológus) Márton Sándor (1965-) (matematikus) Fekete István (1951-) (neurológus, pszichiáter) Horváth László (1973-) (gyógyszerész)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM096400
035-os BibID:(cikkazonosító)721337 (WoS)000703262300001 (Scopus)85115841847
Első szerző:Héja Máté (általános orvos)
Cím:Experiences With Intravenous Thrombolysis in Acute Ischemic Stroke by Elderly Patients? : a "Real World Scenario" / Héja Máté, Fekete István, Horváth László, Márton Sándor, Fekete Klára Edit
Dátum:2021
ISSN:1664-2295
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Neurology. - 12 (2021), p. 1-10. -
További szerzők:Fekete István (1951-) (neurológus, pszichiáter) Horváth László (1973-) (gyógyszerész) Márton Sándor (1965-) (matematikus) Fekete Klára (1978-) (neurológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM096484
Első szerző:Horváth László (gyógyszerész)
Cím:Effect of anticoagulation and antiplatet therapy on the incidence of intracranial bleeding after thrombolysis in patients with acute ischaemic stroke : a pharmacoepidemiological approch / Horváth László, Fekete István, Márton Sándor, Fekete Klára
Dátum:2015
Tárgyszavak:Orvostudományok Klinikai orvostudományok poszter
folyóiratcikk
Megjelenés:European Journal of Hospital Pharmacy. - 22 (2015), p. A189-A190. -
További szerzők:Fekete István (1951-) (neurológus, pszichiáter) Márton Sándor (1965-) (matematikus) Fekete Klára (1978-) (neurológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM079841
035-os BibID:(cikkazonosító)4CPS-171
Első szerző:Horváth László (gyógyszerész)
Cím:The choice of antiepileptic drug treatment after status epilepticus / L. Horváth, I. Fekete, S. Márton, K. Fekete
Dátum:2019
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
status epilepticus
Megjelenés:European Journal of Hospital Pharmacy. - 26 : Suppl. 1 (2019), p. A149. -
További szerzők:Fekete István (1951-) (neurológus, pszichiáter) Márton Sándor (1965-) (matematikus) Fekete Klára (1978-) (neurológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

7.

001-es BibID:BIBFORM078495
035-os BibID:(cikkazonosító)427 (WoS)000466184500001 (Scopus)85067878419 (PMID)31105639
Első szerző:Horváth László (gyógyszerész)
Cím:The outcome of status epilepticus and long-term follow-up / László Horváth, István Fekete, Márk Molnár, Réka Válóczy, Sándor Márton, Klára Fekete
Dátum:2019
ISSN:1664-2295
Megjegyzések:Objective: This study was to investigate the outcome of status epilepticus (SE) associated with antiepileptic therapy during SE and in follow-up period, risk factors including age, co-morbidities, pre-existing epilepsy, and etiology in the East-Hungarian region. Methods: A prospective cross-sectional database was compiled from outpatient files between 2013 and 2017. Follow-up ended on 30.06.2018. Results: One hundred and thirty five episodes (male: 68, 50.4%) were evaluated, mean age and follow-up time being 64.1 +/- 13.9 years and 39.9 +/- 14.2 months, respectively. Of the 89 patients with pre-existing epilepsy, 34 failed to visit the outpatient unit regularly. Case fatality rate was 25.2% and 31 patients (30.7%) died after discharge due to co-morbidities; their mean survival time was 10.44 +/- 8 months. Focal, generalized and combined type epilepsies were diagnosed in 67 patients (49.6%), 47 patients (34.8%), and 21 patients (15.6%) of SE, respectively. Nine patients had non-convulsive SE (NCSE). Mean seizure-free period was 6.8 +/- 6.9 months. Patients taking carbamazepine (20.9%; OR: 0.37, 95% CI: 0.16-0.82; p = 0.018), levetiracetam (27.5%; OR: 0.51, 95% CI: 0.27-0.97; p = 0.041), or valproate (11.1%; OR: 0.18, 95% CI: 0.05-0.61; p = 0.0043) were expected to achieve seizure freedom after SE. The worst outcome was linked to advanced age, etiology, new onset status epilepticus, NCSE, and focal status epilepsy. Conclusion: This study highlights the importance of regular care and patient follow-up.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Neurology. - 10 : 427 (2019), p. 1-8. -
További szerzők:Fekete István (1951-) (neurológus, pszichiáter) Molnár Márk Válóczy Réka Márton Sándor (1965-) (matematikus) Fekete Klára (1978-) (neurológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

8.

001-es BibID:BIBFORM067788
Első szerző:Horváth László (gyógyszerész)
Cím:Outcome of antiepileptic drug treatment of 1282 patients with epilepsy, their pharmacovigilance reports and concomitant medication on CNS in an East-Hungarian adult database / Horváth László, Fekete Klára, Márton Sándor, Fekete István
Dátum:2016
ISSN:0022-510X
Megjegyzések:Objective: The aim of this study was to determine the outcome of antiepileptic drug (AED) treatment based on seizure freedom, pharmacovigilance reports and effects of concomitant medication on the central nervous system (CNS) of adult epileptic patients registered in the East-Hungarian Epilepsy Database.Methods: Prospective cross-sectional database was compiled from outpatient files between 1992 and 2011.Results: The majority of 1282 treated patients were on monotherapy 894 patients (70%), 286 (22%) on bitherapy and 102 (8%) on polytherapy. Of all treated patients, seizure freedom was achieved by 603 (47%). Among the seizure free patients 464 (77%) were on monotherapy, 115 (19%) on bitherapy and only 24 (4%) on polytherapy. The overall rate of adverse drug reactions (ADRs) was 16.2%. From patients on AED, 279 (22%) took concomitant drugs acting on the CNS. In a logistic regression model, other CNS-related drugs and a number of prescribed antiepileptic drugs had a significant influence on the desired outcome of seizure freedom. On comparing the Proportional Reporting Ratio and 95%CI of older and newer AEDs, no significant superiority of newer AEDs was detected.Conclusion: Careful drug selection for epileptic patients must be highlighted in order to improve outcome, reduce ADRs and improve patient compliance.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
epilepsy
database
antiepileptic drug treatment
seizure freedom
adverse drug reaction
pharmacovigilance
Megjelenés:Journal of the Neurological Sciences 369 (2016), p. 220-226. -
További szerzők:Fekete Klára (1978-) (neurológus) Márton Sándor (1965-) (matematikus) Fekete István (1951-) (neurológus, pszichiáter)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

9.

001-es BibID:BIBFORM067789
Első szerző:Horváth László (gyógyszerész)
Cím:Correlation between prescribed daily dose, seizure freedom and defined daily dose in antiepileptic drug treatment / Horváth László, Fekete Klára, Márton Sándor, Fekete István
Dátum:2017
Megjegyzések:Background: Although defined daily doses (DDD) for antiepileptic drugs (AED) have been assigned only in combination therapy, based on the literature, most patients take them in monotherapy. Furthermore, discrepancies between DDD and prescribed daily dose (PDD) were observed.Objective: First, to determine PDDs of AEDs and to reveal PDD/DDD ratio among seizure free vs. not seizure free patients in everyday clinical practice. Second, to test the applicability of 75% cut-off of DDD to achieve seizure freedom. Furthermore, to find out what factors might influence PDD.Setting: Outpatient data files at a Hungarian university hospital were studied.Methods: A retrospective, 20-year cross-sectional database was compiled from 1282 epileptic outpatients' files. Main outcome measure: Seizure freedom and PDD were used as outcome measures.Results: The mean DDD% of all prescribed AEDs increased steadily from monotherapy, through bitherapy towards polytherapy (p<0.0001). Most seizure free patients took AEDs in doses in the range of ?75% of DDDs in monotherapy and bitherapy. Older AEDs (carbamazepine and valproate) were prescribed in a significantly higher mean dose in bitherapy in the seizure free group. Among the newer types, only levetiracetam and lamotrigine had a significantly higher DDD% in mono-, bi-, and polytherapy. Confirmed by logistic regression analysis, gender, age, type of epilepsy, and number of AEDs had a significant impact on the value of 75% DDD.Conclusion: No significant unfavourable impact of the lower ratio of PDD/DDD on the outcome of achieving seizure freedom has been confirmed. As a measure of seizure freedom, 75% of DDD may be used, although individual therapy must be emphasised. Precisely quantified DDD would provide a more accurate calculation of other derived values.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
drug utilization review
epilepsy
PDD
DDD
Hungary
Megjelenés:International Journal of Clinical Pharmacy 37 (2017), p. 459-467. -
További szerzők:Fekete Klára (1978-) (neurológus) Márton Sándor (1965-) (matematikus) Fekete István (1951-) (neurológus, pszichiáter)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1