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001-es BibID:	BIBFORM002770
Első szerző:	Varga Zoltán (biofizikus, szakfordító)
Cím:	Involvement of membrane channels in autoimmune disorders / Zoltán Varga, Péter Hajdu, György Panyi, Rezső Gáspár, Zoltán Krasznai
Dátum:	2007
Megjegyzések:	Ion channels are ubiquitous transmembrane proteins that are involved in a wide variety of cellular functions by selectively controlling the passage of ions across the plasma membrane. Among these functions many immune processes, including those in autoimmune reactions, also rely on the operation of ion channels, but the roles of ion channels can be very diverse. Here the participation of ion channels in three different roles in autoimmune processes is discussed: 1. ion channels in effector immune cells attacking other tissues causing autoimmune diseases, such as multiple sclerosis; 2. ion channels as direct targets of the immune system whereby loss of channel function leads to disease, as in myasthenia gravis; 3. ion channels whose function is modulated in the target cells by an apoptotic signal transduction cascade, such as the Fas/Fas ligand pathway. The numerous tasks that ion channels perform in autoimmune disorders and the wealth of information that has been gathered about them in recent years together provide a good basis for the design and production of drugs that may be effectively used in the therapy of these diseases
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Animals Autoimmune Diseases Biophysics Cell Membrane Cells Humans Hungary Immune System Ion Channels Lymphocyte Activation metabolism physiology Proteins Research Signal Transduction Support T-Lymphocytes therapy
Megjelenés:	Current Pharmaceutical Design. - 13 : 24 (2007), p. 2456-2468. -
További szerzők:	Hajdu Péter (1975-) (biofizikus) Panyi György (1966-) (biofizikus) Gáspár Rezső (1944-) (biofizikus) Krasznai Zoltán (1950-) (biofizikus)
Internet cím:	elektronikus változat
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