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001-es BibID:BIBFORM013812
Első szerző:Szőke Tamás
Cím:Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancer / Szőke Tamás, Klaus Kayser, Jan-Dirk Baumhäkel, Troján Imre, Furák József, Tiszlavicz László, Horváth Ákos, Szluha Kornélia, Hans-Joachim Gabius, Sabine Andre
Megjegyzések:To determine the expression of endogenous adhesion/growth-regulatory lectins and their binding sites using labeled tissue lectins as well as the binding profile of hyaluronic acid as an approach to define new prognostic markers. Methods: Sections of paraffin-embedded histological material of 481 lungs from lung tumor patients following radical lung excision processed by a routine immunohistochemical method (avidin-biotin labeling, DAB chromogen). Specific antibodies against galectins-1 and -3 and the heparin-binding lectin were tested. Staining by labeled galectins and hyaluronic acid was similarly visualized by a routine protocol. After semiquantitative assessment of staining, the results were compared with the pT and pN stages and the histological type. Survival was calculated by univariate and multivariate methods. Results: Binding of galectin-1 and its expression tended to increase, whereas the parameters for galectin-3 decreased in advanced pT and pN stages at a statistically significant level. The number of positive cases was considerably smaller among the cases with small cell lung cancer than in the group with non-small-cell lung cancer, among which adenocarcinomas figured prominently with the exception of galectin-1 expression. Kaplan-Meier computations revealed that the survival rate of patients with galectin-3-binding or galectin-1-expressing tumors was significantly poorer than that of the negative cases. In the multivariate calculations of survival lymph node metastases (p < 0.0001), histological type (p = 0.003), galectin-3-binding capacity (p = 0.01), galectin-3 expression (p = 0.03) and pT status (p = 0.003) proved to be independent prognostic factors, not correlated with the pN stage. Conclusion: The expression and the capacity to bind the adhesion/growth regulatory galectin-3 is defined as an unfavorable prognostic factor not correlated with the pTN stage.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
hyaluronic acid
lung cancer
egyetemen (Magyarországon) készült közlemény
Megjelenés:Oncology. - 69 : 2 (2005), p. 167-174. -
További szerzők:Kayser, Klaus Baumhäkel, Jan-Dirk Troján Imre Furák József Tiszlavicz László Horváth Ákos (1944-) (onkoradiológus) Szluha Kornélia (1955-) (radioterapeuta, radiológus, szülész-nőgyógyász, onkológus) Gabius, Hans-Joachim André, Sabine
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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