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001-es BibID:	BIBFORM014049
Első szerző:	Csillag Anikó (immunológus, biológus, angol-magyar szakfordító)
Cím:	Pollen-Induced Oxidative Stress Influences Both Innate and Adaptive Immune Responses via Altering Dendritic Cell Functions / Csillag, A., Boldogh, I., Pazmandi, K., Magyarics, Z., Gogolak, P., Sur, S., Rajnavolgyi, E., Bacsi, A.
Dátum:	2010
ISSN:	0022-1767
Megjegyzések:	It has been demonstrated that pollen grains contain NAD(P)H oxidases that induce oxidative stress in the airways, and this oxidative insult is critical for the development of allergic inflammation in sensitized mice. On the basis of this observation, we have examined whether pollen grain exposure triggers oxidative stress in dendritic cells (DCs), altering their functions. To test this hypothesis, human monocyte-derived DCs were treated with ragweed pollen grains. Our findings show that exposure to pollen grains induces an increase in the intracellular levels of reactive oxygen species in DCs. Our data also indicate that besides the NAD(P)H oxidases, other component(s) of pollen grains contributes to this phenomenon. Elevated levels of intracellular reactive oxygen species triggered the production of IL-8 as well as proinflammatory cytokines, such as TNF-alpha and IL-6. Treatment with pollen grains initiated the maturation of DCs, strongly upregulated the membrane expression of CD80, CD86, CD83, and HLA-DR, and caused only a slight increase in the expression of CD40. The pollen-treated DCs induced the development of naive T lymphocytes toward effector T cells with a mixed profile of cytokine production. Antioxidant inhibited both the phenotypic and functional changes of DCs, underlining the importance of oxidative stress in these processes. Collectively, these data show that pollen exposure-induced oxidative stress may contribute to local innate immunity and participate in the initiation of adaptive immune responses to pollen Ags.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Allergic Airway Inflammation Exhaust Particle Chemicals Tight Junctions NADPH Oxidase T-Cells Maturation Phytoprostanes Proteins Extracts Gamma
Megjelenés:	Journal of Immunology. - 184 : 5 (2010), p. 2377-2385. -
További szerzők:	Boldogh István Pázmándi Kitti Linda (1984-) (molekuláris biológus, immunológus) Magyarics Zoltán (1982-) (immunológus) Gogolák Péter (1968-) (biológus, immunológus) Sur, Sanjiv Rajnavölgyi Éva (1950-) (immunológus) Bácsi Attila (1967-) (immunológus)
Pályázati támogatás:	NK 72937 OTKA GVOP-3.1.1.-2004-05-0393/3.0 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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