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001-es BibID:BIBFORM015777
Első szerző:Megyesi Zoltán (informatikus)
Cím:Anatomical localization in PET brain receptor studies / Z. Megyesi, T. Spisák, S. A. Kis, G. Opposits, L. Balkay, L. Trón, M. Emri
Megjegyzések:Background: Human and small animal PET receptor studies belong to the most important in vivo tools of pharmaceutical research. The analysis of dynamic PET data requires the use/application of tracer-kinetic and digital brain atlas related image processing methods. The investigation of receptor binding can be support- ed by manually drawn regions or the application of human, mouse or rat brain atlas databases. The latter plays an important role in the anatomical localization, as well. None of the available database software products are capable of handling more than a single data base. The aim of the study was to work out a platform-independent framework and appli- cation that, beyond elementary image processing tasks, enables us to handle sev- eral brain atlas databases at the same time. Result: In accordance with the main objectives a complete program called Brain- Loc has been developed. It supports Talairach Daemon, LONI Probabilistic Brain Atlas (LPBA) and International Consortium for Brain Mapping (ICBM) databases. Based on the strength of this database selecting strategy, a brain atlas dependent numerical value can be rendered to a given location describing the probability that it belongs to a possible anatomical structure. The operation of the elaborated soft- ware has been validated using BrainVoyager and Anatomy Toolbox. Conclusion: BrainLoc may be instrumental in the post processing phase of recep- tor studies by the miniPET-II small animal PET scanner.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Nuclear Medicine Review. - 12 : 1 (2009), p. 48. -
További szerzők:Spisák Tamás (1986-) (programtervező matematikus, informatikus) Kis Sándor Attila (1973-) (fizikus) Opposits Gábor (1974-) (fizikus, szoftver fejlesztő) Balkay László (1963-) (biofizikus) Trón Lajos (1941-) (biofizikus) Emri Miklós (1962-) (fizikus)
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