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001-es BibID:BIBFORM018142
Első szerző:Szentandrássy Norbert (élettanász)
Cím:Effect of thymol on kinetic properties of Ca and K currents in rat skeletal muscle / Szentandrássy Norbert, Szentesi Péter, Magyar János, Nánási Péter Pál, Csernoch László
Megjegyzések:Thymol is widely used as a general antiseptic and antioxidant compound in the medical practice and industry, and also as a stabilizer to several therapeutic agents, including halothane. Thus intoxication with thymol may occur in case of ingestion or improper anesthesia. In the present study, therefore, concentration-dependent effects of thymol (30-600 micro-grams) were studied on calcium and potassium currents in enzymatically isolated rat skeletal muscle fibers using the double vaseline gap voltage clamp technique. Results Thymol suppressed both Ca and K currents in a concentration-dependent manner, the EC50 values were 193 ± 26 and 93 ± 11 mikroM, with Hill coefficients of 2.52 ± 0.29 and 1.51 ± 0.18, respectively. Thymol had a biphasic effect on Ca current kinetics: time to peak current and the time constant for inactivation increased at lower (100-200 mikroM) but decreased below their control values at higher (600 mikroM) concentrations. Inactivation of K current was also significantly accelerated by thymol (200-300 mikroM). These effects of thymol developed rapidly and were partially reversible. In spite of the marked effects on the time-dependent properties, thymol caused no change in the current-voltage relationship of Ca and K peak currents. Conclusions Present results revealed marked suppression of Ca and K currents in skeletal muscle, similar to results obtained previously in cardiac cells. Furthermore, it is possible that part of the suppressive effects of halothane on Ca and K currents, observed experimentally, may be attributed to the concomitant presence of thymol in the superfusate.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:BMC Pharmacology. - 3 (2003), p. 1-8. -
További szerzők:Szentesi Péter (1967-) (élettanász) Magyar János (1961-) (élettanász) Nánási Péter Pál (1956-) (élettanász) Csernoch László (1961-) (élettanász)
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