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001-es BibID:	BIBFORM030627
Első szerző:	Sarnyai Zoltán
Cím:	Effects of cocaine and pimozide on plasma and brain alpha-melanocyte-stimulating hormone levels in rats / Zoltán Sarnyai, Miklós Vecsernyés, János Julesz, Gyula Szabó, Gyula Telegdy
Dátum:	1992
ISSN:	0028-3835
Megjegyzések:	The effects of cocaine on rat plasma and brain alpha-melanocyte-stimulating hormone (alpha-MSH) levels have been studied by means of a specific radioimmunoassay. The selected brain areas were the hypothalamus, septum-nucleus accumbens and hippocampus. Cocaine given subcutaneously decreased the alpha-MSH levels in the peripheral blood. Pimozide, a dopaminergic antagonist, had an opposite effect: it increased the alpha-MSH levels in the peripheral blood. Combined treatment with cocaine + pimozide resulted in a decrease in the pimozide-induced increase in alpha-MSH levels in the blood. Cocaine and pimozide or the combination of cocaine + pimozide were ineffective on the alpha-MSH levels in the hypothalamus and septum-accumbens brain regions. In the hippocampus, cocaine in the dose applied induced a slight but not significant decrease in the alpha-MSH level. Pimozide caused a significant decrease in the hippocampal alpha-MSH level which disappeared at 60 min. Cocaine prevented the pimozide-induced depletion of alpha-MSH. The data indicate that cocaine may act as a dopaminergic agonist in the mechanism of control of alpha-MSH secretion from the intermediate lobe of the pituitary. The alpha-MSH levels in the brain are controlled by different mechanisms. In some brain areas, the dopaminergic system has no action; in others the mechanisms might be similar to but slightly different from that in the pituitary.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban cocaine pimozine alpha-melanocyte-stimulating hormone egyetemen (Magyarországon) készült közlemény
Megjelenés:	Neuroendocrinology 55 : 1 (1992), p. 9-13. -
További szerzők:	Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Julesz János Szabó Gyula (Szeged) Telegdy Gyula (Szeged)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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