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001-es BibID:BIBFORM042086
Első szerző:Gomez Izabella (orvos)
Cím:In vivo calcium and phosphate iontophoresis on osteoporotic rat tibia. A new method for the topical treatment of osteoporosis / Gomez Izabella, Pap Lajos, Szabó Andrea, Boda Krisztina, Szekanecz Zoltán
Megjegyzések:Background: In the management of osteoporosis in addition to pharmaceutical therapy and diet, physiotherapy may also be included. Our research group developed a novel three-electrode iontophoretic apparatus involving the use of calcium- and phosphate-donating lattice suitable for local ion delivery into the bones. We performed in vivo studies on rats in order to compare the effects and efficacy of electrotherapy with that of systemic hormone replacement therapy.Materials and methods: Five months after the operation tibias of Sham and ovarectomized (OVX) Sprague-Dawley female rats were subjected to serial local iontophoretic treatment(IOP). Other OVX rats received systemic subcutaneous 17-beta-oestradiol therapy (E2,100ug/kg/day for 13 weeks) or were also treated with the combination of IOP and E2. Changes in bone density were detected for 90 days after IOP. At the end of the experiments, biomechanical studies were performed together with elemental analysis assessing the calcium and phosphate concentrations.Results: Serial iontophoretic treatment resulted in a longlasting increase in bone density in both the Sham and OVX animals. Similar changes could be detected after E2 monotherapy, further enhancement could be observed applyingE2 + IOP. The above improvement was also evident regardingthe biomechanical features of the tibias as reduced calcium and phosphate content of the bones caused by OVX could be reversed by IOP or E2 monotherapy, as well as combination therapy.Conclusions: Iontophoresis using calcium- and phosphate donating microparticles further enhances the efficacy of estrogen therapy by increasing bone density, restoring the calcium and phosphate balance and the biomechanical properties of the bone.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:European Journal of Clinical Investigation. - 42 : Suppl.1 (2012), p. 66-67. -
További szerzők:Pap Lajos (1929-) (vegyész, analitikus) Szabó Andrea Boda Krisztina Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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