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001-es BibID:	BIBFORM046534
Első szerző:	Szántó Sándor (belgyógyász, reumatológus)
Cím:	Expression of L-selectin, but not CD44, is required for early neutrophil extravasation in antigen-induced arthritis / Sándor Szántó, István Gál, Andrea Gonda, Tibor T. Glant, Katalin Mikecz
Dátum:	2004
Megjegyzések:	L (leukocyte)-selectin (CD62L) and CD44 are major adhesion receptors that support the rolling of leukocytes on endothelium, the first step of leukocyte entry into inflamed tissue. The specific contribution of L-selectin or CD44 to the regulation of cell traffic to joints in arthritis has not been investigated. We used CD44-deficient, L-selectin-deficient, and CD44/L-selectin double knockout mice to determine the requirement for these receptors for inflammatory cell recruitment during Ag-induced arthritis. Intraperitoneal immunization resulted in similar activation status and Ag-specific responses in wild-type and gene-targeted mice. However, extravasation of neutrophil granulocytes, but not the emigration of T cells, into the knee joints after intra-articular Ag injection was significantly delayed in L-selectin-deficient and double knockout mice. Intravital videomicroscopy on the synovial microcirculation revealed enhanced leukocyte rolling and diminished adherence in mice lacking either CD44 or L-selectin, but CD44 deficiency had no significant effect on the recruitment of L-selectin-null cells. Compared with wild-type leukocytes, expression of L-selectin was down-regulated in CD44-deficient cells in the spleen, peripheral blood, and inflamed joints, suggesting that reduced expression of L-selectin, rather than the lack of CD44, could be responsible for the delayed influx of granulocytes into the joints of CD44-deficient mice. In conclusion, there is a greater requirement for L-selectin than for CD44 for neutrophil extravasation during the early phase of Ag-induced arthritis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	The Journal of Immunology. - 172 : 11 (2004), p. 6723-6734. -
További szerzők:	Gál István (1957-) (belgyógyász) Gonda Andrea (1970-) (onkológus szakorvos) Glant Tibor T. Mikecz Katalin
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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