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001-es BibID:BIBFORM049171
Első szerző:Kobezda Tamás (Ph.D hallgató)
Cím:Of mice and men : how animal models advance our understanding of T-cell function in RA / Tamás Kobezda, Sheida Ghassemi-Nejad, Katalin Mikecz, Tibor T. Glant, Zoltán Szekanecz
ISSN:1759-4790 1759-4804
Megjegyzések:The involvement of autoreactive T cells in the pathogenesis of rheumatoid arthritis (RA) as well as in autoimmune animal models of arthritis has been well established; however, unanswered questions, such as the role of joint-homing T cells, remain. Animal models of arthritis are superb experimental tools in demonstrating how T cells trigger joint inflammation, and thus can help to further our knowledge of disease mechanisms and potential therapies. In this Review, we discuss the similarities and differences in T-cell subsets and functions between RA and mouse arthritis models. For example, various T-cell subsets are involved in both human and mouse arthritis, but differences might exist in the cytokine regulation and plasticity of these cells. With regard to joint-homing T cells, an abundance of synovial T cells is present in humans compared with mice. On the other hand, local expansion of type 17 T-helper (TH17) cells is observed in some animal models, but not in RA. Finally, whereas T-cell depletion therapy essentially failed in RA, antibody targeting of T cells can work, at least preventatively, in most arthritis models. Clearly, additional human and animal studies are needed to fill the gap in our understanding of the specific contribution of T-cell subsets to arthritis in mice and men.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
T-cell responses
T-cell clonal expansion
Megjelenés:Nature Reviews Rheumatology. - 10 : 3 (2014), p. 160-170. -
További szerzők:Ghassemi-Nejad, Sheida (1980-) (fogorvos) Mikecz Katalin Glant Tibor T. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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