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001-es BibID:	BIBFORM051954
Első szerző:	Panyi György (biofizikus)
Cím:	Ion channels and anti-cancer immunity / Gyorgy Panyi, Christine Beeton, Antonio Felipe
Dátum:	2014
Megjegyzések:	The outcome of a malignant disease depends on the efficacy of the immune system to destroy cancer cells. Key steps in this process, for example the generation of a proper Ca(2+) signal induced by recognition of a specific antigen, are regulated by various ion channel including voltage-gated Kv1.3 and Ca(2+)-activated KCa3.1 K(+) channels, and the interplay between Orai and STIM to produce the Ca(2+)-release-activated Ca(2+) (CRAC) current required for T-cell proliferation and function. Understanding the immune cell subset-specific expression of ion channels along with their particular function in a given cell type, and the role of cancer tissue-dependent factors in the regulation of operation of these ion channels are emerging questions to be addressed in the fight against cancer disease. Answering these questions might lead to a better understanding of the immunosuppression phenomenon in cancer tissue and the development of drugs aimed at skewing the distribution of immune cell types towards killing of the tumour cells
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban article Biophysics cell biology Cells EXPRESSION Hungary Immune System Immunosuppression Ion Channels Research Research Support Support
Megjelenés:	Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. - 369 : 1638 (2014), p. 20130106. -
További szerzők:	Beeton, Christine Felipe, Antonio
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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