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001-es BibID:	BIBFORM078543
035-os BibID:	(WOS)000491345500004 (Scopus)85064507740 (PMID)30957464
Első szerző:	Dömötör Johanna (neurológus)
Cím:	EEG-based connectivity in patients with partial seizures with and without generalization / Johanna Dömötör, Béla Clemens, Miklós Emri, Szilvia Puskás, István Fekete
Dátum:	2019
ISSN:	0019-1442 2498-6208
Megjegyzések:	Objective ? to investigate the neurophysiological basis of secondary generalization of partial epileptic seizures. Patients and methods ? inter-ictal, resting-state EEG functional connectivity (EEGfC) was evaluated and compared: patients with exclusively simple partial seizures (sp group) were compared to patients with simple partial and secondary generalized seizures (spsg group); patients with exclusively complex partial seizures (cp group) were compared to patients with cp and secondary generalized seizures (cpsg group); the collapsed sp+cp group (spcp) was compared to those who had exclusively secondary generalized seizures (sg group). EEGfC was computed from 21-channel waking EEG. 3 minutes of waking EEG background activity was analyzed by the LORETA Source Correlation (LSC) software. Current source density time series were computed for 23 pre-defined cortical regions (ROI) in each hemisphere, for the 1-25 Hz very narrow bands (1 Hz bandwidth). Thereafter Pearson correlation coefficients were calculated between all pairs of ROI time series in the same hemisphere. Z-scored correlation coefficients were compared at the group level (t-tests and correction for multiple comparisons by local false discovery rate, FDR). Results ? Statistically significant (corrected p<0.05) EEGfC differences emerged at specific frequencies (spsg > sg; cpsg > cp), and at many frequencies (sg > spcp). The findings indicated increased coupling between motor cortices and several non-motor areas in patients with partial and sg seizures as compared to patients with partial seizures and no sg seizures. Further findings suggested increased coupling between medial parietal-occipital areas (structural core of the cortex) and lateral hemispheric areas. Conclusion ? increased inter-ictal EEGfC is associated with habitual occurrence of secondary generalized seizures.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk epilepsy partial seizures secondary generalization EEG functional connectivity
Megjelenés:	Ideggyógyászati Szemle. - 72 : 3-4 (2019), p. 99-109. -
További szerzők:	Clemens Béla (1950-) (neurológus) Emri Miklós (1962-) (fizikus) Puskás Szilvia (1979-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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