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001-es BibID:BIBFORM087278
035-os BibID:(WoS)000492444403175
Első szerző:Képes Zita (orvos)
Cím:Examinantion of brain perfusion and metabolism in metabolic diseases (focusing on diabetes and obesity) / Zita Képes, J. Varga, F. Nagy, M. Emri, M. Káplár, Cs. Aranyi, I. Garai
ISSN:1619-7070 1619-7089
Megjegyzések:Aim/Introduction: Microcircular alterations that could already be observed in prediabetic state (obesity and insulin resistance) are supposed to have significant role in the developement of the consequences of diabetes mellitus. The main aim of our study was to compare the cerebrovascular microcirculation and metabolism of obese patients and patients suffering from type 2 diabetes mellitus. Materials and Methods: In our prospective study 57 patients with controlled type 2 diabetes mellitus (52?9,6 years) and 46 obese patients (50,6?7,9 years) were enrolled. BMI proved to be 34,06?5,94 in the diabetic group while it was 38,14?6,06 among the obese patients. Dynamic Tc99m-HMPAO study (AnyScanFlex, Mediso) was performed for evaluation of hemispheral perfusion using Patlak analysis. Then tomographic imaging was carried out at rest condition. Brain metabolism was estimated applying 18F-FDG PET/CT (AnyScan PC, Mediso). FDG and HMPAO scans were transformed to MNI152 brain map after T1 registration and used for SPM (Statistical Parametric Mapping) analysis. NeuroQ application (Syntermed) was used to evaluate regional differences. Statistical analysis (Shapiro-Wilk, Wilcoxon, Spearman correlation) was applied for assessment of group differences. Results: Hemispheral perfusion calculated with Patlak analysis showed positive correlation with BMI (rho=0.35, p=0.016). There were no significant differences in hemispheral and regional perfusion in T2DM and the obese group. However, we found hypometabolism in right and left cuneus (Br17) in T2DM with SPM analysis. NeuroQ analysis did not reveal significant regional perfusion or metabolic defects in either groups. Conclusion: Based on current literature hypometabolism in the region of the cuneus is a characteristic feature of neurodegenerative diseases. The reason why no significant perfusion defects were found could be explained by the fact that the enrolled diabetics were therapeutically well managed. Unexpected significant correlation with BMI is unclear, further investigation is required. References: None
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:European Journal of Nuclear Medicine and Molecular Imaging. - 46 : S1 (2019), p. S399-S400. -
További szerzők:Varga József (1955-) (fizikus) Nagy Ferenc (1984-) (fizikus) Emri Miklós (1962-) (fizikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Aranyi Sándor Csaba (1988-) (programtervező informatikus) Garai Ildikó (1966-) (radiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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