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001-es BibID:BIBFORM087915
Első szerző:Török Péter (szülész-nőgyógyász)
Cím:Preoperative assessment of endometrial cancer / Péter Török, Zoárd Krasznai, Szabolcs Molnár, Rudolf Lampé, Attila Jakab
ISSN:2218-676X 2219-6803
Megjegyzések:Endometrial cancer (EC), the most common among gynaecological malignancies occurs predominantly after the menopause. The diagnosis is most commonly (in about 75?80%) set up at early stage when surgical therapy and if necessary postoperative radiotherapy results in an excellent prognosis, with a 90?95% 5-year overall survival (OS) and a locoregional recurrence rates of 4?8%. Accurate preoperative assessment of the lymph nodes would ideally identify those patients with advanced stage disease, who might benefit from more extensive surgical procedures and adjuvant therapies. magnetic resonance imaging (MRI), hysteroscopic excisional biopsy (HEB) and high resolution 2D or 3D ultrasound performed by expert operator are considered to add valuable information for preoperative staging of EC. The use of biomarkers could be beneficial in decreasing inter-observer variability between the histology of the diagnostic specimen and the final operative sample, as well as to avoid overtreatment in a part of the high-grade tumors with excellent prognosis. The goal of surgical management of EC is to remove the primary tumor and to identify definite prognostic factors to determine whether adjuvant therapy is required. Extended surgery, including para-aortic lymphadenectomy has a significant morbidity, and with the future selection of cases it can be safely avoided, we can decrease complications without compromising oncological safety. In the future, the importance of hysteroscopy guided sampling may increase to gain a representative sample for biomarker detection.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
endometrial cancer
magnetic resonance imaging
Megjelenés:Translational Cancer Research. - 9 : 12 (2020), p. 7746-7758. -
További szerzők:Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Molnár Szabolcs (1987-) (szülész-nőgyógyász szakorvos) Lampé Rudolf (1983-) (szülész-nőgyógyász) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
Internet cím:DOI
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