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001-es BibID:BIBFORM095056
035-os BibID:(WoS)000673316300001 (Scopus)85110713637
Első szerző:Szabó Gábor (PhD-hallgató)
Cím:Laboratory Approaches to Test the Function of Antiphospholipid Antibodies / Gábor Szabó, Péter Antal-Szalmás, Adrienne Kerényi, Krisztina Pénzes, Bálint Bécsi, János Kappelmayer
Megjegyzések:Antiphospholipid syndrome (APS) is a systemic autoimmune disorder caused by the presence of aPLs (antiphospholipid antibodies, i.e., anti-?2-glycoprotein I and anticardiolipin). Everyday practice in terms of laboratory diagnostics of APS includes determination of aPLs and well-known functional assays assessing for lupus anticoagulant (LA), in turn using various tests. According to recent guidelines, the recommended method for LA identification or exclusion is based on the Russell Viper Venom test and a sensitive activated partial thromboplastin time assay. Despite the fact that LA can be quantified in laboratory practice in this way, LA is still used as a binary parameter that is just one of the risk factors of thrombosis in APS. As of today, there are no other functional assays to routinely assess the risk of thrombosis in APS. It is well-known that APS patients display a wide range of clinical outcomes although they may express very similar laboratory findings. One way to solve this dilemma, could be if antibodies could be further delineated using more advanced functional tests. Therefore, we review the diagnostic approaches to test the function of aPLs. We further discuss how thrombin generation assays, and rotational thromboelastometry tests can be influenced by LA, and how experimental methods, such as flow cytometric platelet activation, surface plasmon resonance, or nano differential scanning fluorimetry can bring us closer to the puzzling interaction of aPLs with platelets as well as with their soluble protein ligand. These novel approaches may eventually enable better characterization of aPL, and also provide a better linkage to APS pathophysiology.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
antiphospholipid antibodies
Megjelenés:Seminars In Thrombosis And Hemostasis. - 48 : 2 (2022), p. 132-144. -
További szerzők:Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Kerényi Adrienne (1970-) (laboratóriumi szakorvos) Pénzes-Daku Krisztina (1978-) (biológus) Bécsi Bálint (1981-) (vegyészmérnök) Kappelmayer János (1960-) (laboratóriumi szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00044
OTKA_K_16 120725
Internet cím:DOI
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