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001-es BibID:BIBFORM100255
Első szerző:Nagy Károly (népegészségügyi felügyelő)
Cím:Toxicity of pesticide active ingredients compared to their product formulations / Nagy Károly, Duca Radu Corneliu, Lovas Szabolcs, Creta Matteo, Scheepers Paul T. J., Godderis Lode, Ádám Balázs
ISSN:2093-7911 2093-7997
Megjegyzések:Introduction: Farmers are exposed to complex chemical mixtures; however, the approval of pesticide products is still mostly limited to testing the toxicity of individual ingredients ignoring possible in- teractions. The objective of the study was to systematically review the literature of in vitro and in vivo studies that compare the toxicity of pesticide product formulations and their declared active ingredients. Material and Methods: PubMed and Scopus were searched using the following terms: "pesticide", "formulation", "commercial product", "commercial pesticide" and "health". After screening by predefined inclusion and exclusion criteria, quality and reliability assessment was conducted by the ToxRTool. Two investigators independently screened the identified publications and extracted results from eligible studies. Results: Our search yielded 36 studies, including 23 that investi- gated herbicides, 15 insecticides, and 4 fungicides. 24 studies re- ported increased toxicity of the product formulations versus their active ingredients, which in most cases was attributed to the presence of adjuvants. Ten studies compared glyphosate and glyphosate-based herbicides, and six of them concluded that Roundup, the dominant product formulation of glyphosate, is more toxic than glyphosate alone. Conclusions: The results demonstrate that ignoring the possible risks of interaction between the active and other ingredients of commercial pesticide product formulations might result in the misinterpretation of their toxicological profile. We recommend that all product formulations should be fully assessed during the authorization process.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
Megjelenés:Safety and Health at Work. - 13 (2022), p. S256-S257. -
További szerzők:Duca, Radu Corneliu Lovas Szabolcs (1989-) (tudományos segédmunkatárs) Creta, Matteo Scheepers, Paul T. J. Godderis, Lode Ádám Balázs (1973-) (megelőző orvostan és népegészségtan szakorvos)
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